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Environmental Health PHGKB

Specific PHGKB|Environmental Health PHGKB|Public Health Genomics and Precision Health Knowledge Base (PHGKB)
Effective August 1, 2024, this database was discontinued. All content will remain searchable and be preserved online for historical purposes only until 2029.

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Crossing the Equity Chasm: Addressing a Second Valley of Death in Biomedical Innovation

From the article: "Recent transformative advances in health and medicine have successfully traversed the valley of death, including progress in genomics, precision medicine, innovative medicines and vaccines, gene therapy, and artificial intelligence. However, it is critical to call attention to a second, important valley of death: the failure to deliver scientific advances to populations most in need. The second valley of death is fueled by socioeconomic, environmental, political, and systemic factors; health system failures; and persistent challenges in closing the last mile in health care, resulting in significant disparities in morbidity and mortality worldwide. "

Precision public health in the era of genomics and big data

From the abstract: "Precision public health (PPH) considers the interplay between genetics, lifestyle and the environment to improve disease prevention, diagnosis and treatment on a population level—thereby delivering the right interventions to the right populations at the right time. In this Review, we explore the concept of PPH as the next generation of public health. We discuss the historical context of using individual-level data in public health interventions and examine recent advancements in how data from human and pathogen genomics and social, behavioral and environmental research, as well as artificial intelligence, have transformed public health. "

Connecting lab, clinic, and community

From the article: "To better understand relationships between the genes we inherit and the environmental and societal factors that surround us and to deliver more evidence-driven health care, research must be integrated into clinical care and community settings, reaching patients from all walks of life. Unlike most research settings, primary care is patient- and community-centered and emphasizes health maintenance and preventive care alongside treatment and rehabilitation in a location as convenient as possible for the patient. "

Gene–environment interactions in human health

From the abstract: "Gene–environment interactions (G×E), the interplay of genetic variation with environmental factors, have a pivotal impact on human complex traits and diseases. Statistically, G×E can be assessed by determining the deviation from expectation of predictive models based solely on the phenotypic effects of genetics or environmental exposures. Despite the unprecedented, widespread and diverse use of G×E analytical frameworks, heterogeneity in their application and reporting hinders their applicability in public health. "


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de Azevedo Lais Sampaio, et al. Acta tropica 2024 0 0. 107449
Developing a machine learning model with enhanced performance for predicting COVID-19 from patients presenting to the emergency room with acute respiratory symptoms. External Web Site Icon
Alghamdi Maha Mesfer, et al. IET systems biology 2024 0 0.
The utility of wastewater surveillance for monitoring SARS-CoV-2 prevalence. External Web Site Icon
Mills Cathal, et al. PNAS nexus 2024 0 0. (10) pgae438
[Comparison of triclosan and triclocarban in triggering immunotoxicity in larval zebrafish]. External Web Site Icon
Cheng Ying, et al. Sheng wu gong cheng xue bao = Chinese journal of biotechnology 2024 0 0. (10) 3765-3780
Chinese Public Attitudes and Opinions on Health Policies During Public Health Emergencies: Sentiment and Topic Analysis. External Web Site Icon
Liu Min, et al. Journal of medical Internet research 2024 0 0. e58518
Impact of COVID-19 restrictions liberalization on air quality: a case study of Chongqing, Southwest China. External Web Site Icon
Wang Haozheng, et al. Environmental monitoring and assessment 2024 0 0. (11) 1111
Investigations on the surface disinfection efficacy of far-UVC 222 nm germicidal irradiance device in a controlled environment and field test. External Web Site Icon
Leow Chee Huan, et al. Journal of environmental health science & engineering 2024 0 0. (2) 569-577
S-RBD-modified and miR-486-5p-engineered exosomes derived from mesenchymal stem cells suppress ferroptosis and alleviate radiation-induced lung injury and long-term pulmonary fibrosis. External Web Site Icon
Zhang Wei-Yuan, et al. Journal of nanobiotechnology 2024 0 0. (1) 662
A CRISPR-Cas13b System Degrades SARS-CoV and SARS-CoV-2 RNA In Vitro. External Web Site Icon
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New Evidence for the Role of the Blood-Brain Barrier and Inflammation in Stress-Associated Depression: A Gene-Environment Analysis Covering 19,296 Genes in 109,360 Humans. External Web Site Icon
Gal Zsofia, et al. International journal of molecular sciences 2024 0 0. (20)

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About EH PHGKB

Environmental Health PHGKB is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other materials that address the use of genomic and other precision health technologies in addressing environmental health issues including epidemiology, translation, policies and guidelines and population health programs and impact...more


Disclaimer: Articles listed in the Public Health Knowledge Base are selected by Public Health Genomics Branch to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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