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Environmental Health PHGKB

Specific PHGKB|Environmental Health PHGKB|PHGKB

Last Posted: Nov 21, 2022
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Multi-omics signatures of the human early life exposome
L Maitre et al, Nature Comm, November 21, 2022

In the Human Early Life Exposome (HELIX) project, a multi-centre cohort of 1301 mother-child pairs, we associate individual exposomes consisting of >100 chemical, outdoor, social and lifestyle exposures assessed in pregnancy and childhood, with multi-omics profiles (methylome, transcriptome, proteins and metabolites) in childhood. We identify 1170 associations, 249 in pregnancy and 921 in childhood, which reveal potential biological responses and sources of exposure. Pregnancy exposures, including maternal smoking, cadmium and molybdenum, are predominantly associated with child DNA methylation changes.

Gene-environment interactions in Alzheimer disease: the emerging role of epigenetics.
Migliore Lucia et al. Nature reviews. Neurology 2022 9 (11) 643-660

With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex aetiology that is likely to involve multiple susceptibility genes and environmental factors. The role of environmental factors is difficult to determine and, until a few years ago, the molecular mechanisms underlying gene–environment (G?×?E) interactions in AD were largely unknown. Here, we review evidence that has emerged over the past two decades to explain how environmental factors, such as diet, lifestyle, alcohol, smoking and pollutants, might interact with the human genome. In particular, we discuss how various environmental AD risk factors can induce epigenetic modifications of key AD-related genes and pathways.

Algorithms and the Future of Work
J Howard, NIOSH Blog, September 2022

In the future of work, algorithms will provide many beneficial applications in occupational safety and health. While algorithm-enabled systems and devices may reduce sources of human error and enhance worker safety and health, algorithms may also introduce new sources of risks to worker wellbeing. To ensure that the benefits of algorithm-enabled systems and devices have a prominent place in the future of work, now is the time to study how to effectively manage their risks.

Measurement of Exhaled Volatile Organic Compounds as a Biomarker for Personalised Medicine: Assessment of Short-Term Repeatability in Severe Asthma
A Azim et al, J Per Medicine, September 29, 2022

The intra-subject and between-subject variability of each VOC was calculated across the 70 samples and identified 30.35% of VOCs to be erratic: variable between subjects but also variable in the same subject. Exclusion of these erratic VOCs from machine learning approaches revealed no apparent loss of structure to the underlying data or loss of relationship with salient clinical characteristics. Moreover, cluster evaluation by the silhouette coefficient indicates more distinct clustering.

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