Impact of paternal education on epigenetic ageing in adolescence and mid-adulthood: a multi-cohort study in the USA and Mexico.
Joyce Brian T et al. International journal of epidemiology 2021 9
Both parental and neighbourhood socio-economic status (SES) are linked to poorer health independently of personal SES measures, but the biological mechanisms are unclear. Our objective was to examine these influences via epigenetic age acceleration (EAA)—the discrepancy between chronological and epigenetic ages.We examined three USA-based [Coronary Artery Risk Disease in Adults (CARDIA) study, Fragile Families and Child Wellbeing Study (FFCWS) and Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS)] and one Mexico-based (Project Viva) cohort. Our findings suggest that EAA captures epigenetic impacts of paternal education independently of personal SES later in life.
Mendelian Randomization: Using Genetics to Study Behaviors and Environments that Cause Disease
CDC, August 2021
An important part of public health research is looking at whether behaviors, environments, and other factors, which can sometimes be changed, make people more likely to get certain diseases. However, showing that these factors cause a specific disease presents challenges. Mendelian randomization studies examine how certain behaviors, environments, or other factors lead to specific health outcomes by looking at genetic differences that affect the way people’s bodies react to the behavior, environment, or other factors.
Harnessing electronic health records to study emerging environmental disasters: a proof of concept with perfluoroalkyl substances (PFAS)
MR Boland et al, NPJ Digital Medicine, August 11, 2021
We propose the use of electronic health records (EHR) and informatics methods to study the health effects of emergent environmental disasters in a cost-effective manner. An emergent environmental disaster is exposure to perfluoroalkyl substances (PFAS) in the Philadelphia area. Penn Medicine (PennMed) comprises multiple hospitals and facilities within the Philadelphia Metropolitan area, including over three thousand PFAS-exposed women living in one of the highest PFAS exposure areas nationwide.
The Contributions of Host Genomics Research to the COVID-19 Response: It’s Not Just About Genes!
E Drzymalla et al, CDC Blog Post, August 3, 2021
Although host genomics studies in COVID-19 are still a work in progress, this type of research has the potential for both a direct public health benefit resulting from genetic knowledge itself and an indirect benefit resulting from the use of genetics to identify modifiable environmental factors. A landmark international collaborative study did both.
News and Publications
Stability and bifurcation analysis of SIQR for the COVID-19 epidemic model with time delay.
Wang Shishi, et al. Mathematical biosciences and engineering : MBE 2021 0 0. (5) 5505-5524
The risk of future waves of COVID-19: modeling and data analysis.
He Sha, et al. Mathematical biosciences and engineering : MBE 2021 0 0. (5) 5409-5426
The role of spike protein mutations in the infectious power of SARS-COV-2 variants: A molecular interaction perspective.
Gomez Santiago A, et al. Chembiochem : a European journal of chemical biology 2021 0 0.
Viral outbreaks detection and surveillance using wastewater-based epidemiology, viral air sampling, and machine learning techniques: A comprehensive review and outlook.
Abdeldayem Omar M, et al. The Science of the total environment 2021 0 0. 149834
An observational and Mendelian randomisation study on vitamin D and COVID-19 risk in UK Biobank.
Li Xue, et al. Scientific reports 2021 0 0. (1) 18262
Early Warning Diagnostics for Emerging Infectious Diseases in Developing into Late-Stage Pandemics.
Oeschger Taylor M, et al. Accounts of chemical research 2021 0 0.
The viral phoenix: enhanced infectivity and immunity evasion of SARS-CoV-2 variants.
Choi Hosoon, et al. Environmental chemistry letters 2021 0 0. 1-6
Challenging the dogma of the healthy heterozygote: Implications for newborn screening policies and practices.
Farrell Philip M et al. Molecular genetics and metabolism 2021
Public knowledge and opinion of epigenetics and epigenetic concepts.
Lynch Fiona et al. Journal of developmental origins of health and disease 2021 1-10
A Novel Smart City-Based Framework on Perspectives for Application of Machine Learning in Combating COVID-19.
Ezugwu Absalom E, et al. BioMed research international 2021 0 0. 5546790