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Environmental Health PHGKB

Specific PHGKB|Environmental Health PHGKB|PHGKB

Last Posted: Aug 08, 2022
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Rare genetic variants explain missing heritability in smoking.
Jang Seon-Kyeong et al. Nature human behaviour 2022 8

We investigated the contribution of rare genetic variants to tobacco use with whole-genome sequences from up to 26,257 unrelated individuals of European ancestries and 11,743 individuals of African ancestries. Across four smoking traits, single-nucleotide-polymorphism-based heritability (h2SNP) was estimated from 0.13 to 0.28 (s.e., 0.10–0.13) in European ancestries, with 35–74% of it attributable to rare variants with minor allele frequencies between 0.01% and 1%. These heritability estimates are 1.5–4 times higher than past estimates based on common variants alone.

Nongenetic Factors Associated With Psychotic Experiences Among UK Biobank Participants Exposome-Wide Analysis and Mendelian Randomization Analysis
BD Lin et al, JAMA Psychiatry, July 20, 2022

What are the factors associated with psychotic experiences? In this cohort study of 155?247 UK Biobank participants, exposome-wide association analysis yielded 148 correlates of psychotic experiences, with 36 independent associations further identified in the fully adjusted multivariable model. Mendelian randomization analyses of these 36 variables indicated a forward association with ever having experienced sexual assault and pleiotropy of risk-taking behavior and a reverse association with ever having experienced a physically violent crime, cannabis use, and worrying too long after embarrassment.

Virtual Workshop on Integrating Climate and Environmental Data and Justice into the All of Us Research Program
NIH, All of Us Research Program Workshop, July 28-29, 2022

The goal of this workshop is to discuss innovative project ideas for potential Ancillary Studies between the All of Us Research Program and the National Institute for Environmental Health Sciences. An ‘Ancillary Study’ is one that creates a new data type for All of Us by virtue of the question(s) it aims to answer. Ancillary Studies may also add new participants to the program. Workshop participants will also discuss environmental exposures or data linkages that should be considered for collection in the entire All of Us cohort.

All of Us Research Program Seeks Input on Environmental Health Data
NIH, May 5, 2022

The National Institutes of Health’s All of Us Research Program has issued a Request for Information (RFI) to gather public suggestions on integrating environmental health data into its platform for data analysis, the Researcher Workbench. Inclusion of this data will drive new areas of research and insights on the influence of the environment, alongside social, biological, and other determinants of health.


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Delay differential equations for the spatially resolved simulation of epidemics with specific application to COVID-19. External Web Site Icon
Guglielmi Nicola, et al. Mathematical methods in the applied sciences 2022 0 0.
SARS-CoV-2 pan-variant inhibitory peptides deter S1-ACE2 interaction and neutralize delta and omicron pseudoviruses. External Web Site Icon
Shah Masaud, et al. Computational and structural biotechnology journal 2022 0 0. 2042-2056
First-onset major depression during the COVID-19 pandemic: A predictive machine learning model. External Web Site Icon
Caldirola Daniela et al. Journal of affective disorders 2022
Overlapping Delta and Omicron Outbreaks: Dynamic Panel Data. External Web Site Icon
Lundberg Alexander L et al. JMIR public health and surveillance 2022 5
Tracking SARS-CoV-2 mutations and variants through the COG-UK-Mutation Explorer. External Web Site Icon
Wright Derek W et al. Virus evolution 2022 5 (1) veac023
A machine learning and clustering-based approach for county-level COVID-19 analysis. External Web Site Icon
Nicholson Charles, et al. PloS one 2022 0 0. (4) e0267558
An ensemble model based on early predictors to forecast COVID-19 health care demand in France. External Web Site Icon
Paireau Juliette, et al. Proceedings of the National Academy of Sciences of the United States of America 2022 0 0. (18) e2103302119
'We're kind of like genetic nomads': Parents' experiences of biographical disruption and uncertainty following in/conclusive results from newborn cystic fibrosis screening. External Web Site Icon
Boardman Felicity et al. Social science & medicine (1982) 2022 301114972
Association of Lipoprotein (a) in Coronary Artery Disease in Young Individuals. External Web Site Icon
Patted Aishwarya et al. The Journal of the Association of Physicians of India 2022 70(4) 11-12
The Clinically Actionable Molecular Profile of Early versus Late-Stage Non-Small Cell Lung Cancer, an Individual Age and Sex Propensity-Matched Pair Analysis. External Web Site Icon
McGuire Anna L et al. Current oncology (Toronto, Ont.) 2022 29(4) 2630-2643

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Disclaimer: Articles listed in the Public Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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