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Environmental Health PHGKB

Specific PHGKB|Environmental Health PHGKB|PHGKB

Last Posted: May 09, 2022
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All of Us Research Program Seeks Input on Environmental Health Data
NIH, May 5, 2022

The National Institutes of Health’s All of Us Research Program has issued a Request for Information (RFI) to gather public suggestions on integrating environmental health data into its platform for data analysis, the Researcher Workbench. Inclusion of this data will drive new areas of research and insights on the influence of the environment, alongside social, biological, and other determinants of health.

Making sense of the ageing methylome.
Seale Kirsten et al. Nature reviews. Genetics 2022 5

Over time, the human DNA methylation landscape accrues substantial damage, which has been associated with a broad range of age-related diseases, including cardiovascular disease and cancer. Various age-related DNA methylation changes have been described, including at the level of individual CpGs, such as differential and variable methylation, and at the level of the whole methylome, including entropy and correlation networks. Here, we review these changes in the ageing methylome as well as the statistical tools that can be used to quantify them. We detail the evidence linking DNA methylation to ageing phenotypes and the longevity strategies aimed at altering both DNA methylation patterns and machinery to extend healthspan and lifespan. Lastly, we discuss theories on the mechanistic causes of epigenetic ageing.

Repeat measures of DNA methylation in an inception cohort of firefighters.
Goodrich Jaclyn M et al. Occupational and environmental medicine 2022 3

Firefighters face exposures associated with adverse health outcomes including risk for multiple cancers. DNA methylation, one type of epigenetic regulation, provides a potential mechanism linking occupational hazards to adverse health outcomes. We hypothesized that DNA methylation profiles would change in firefighters after starting their service and that these patterns would be associated with occupational exposures (cumulative fire-hours and fire-runs).

Geospatial Determinants of Health
ATSDR, 2022

Geospatial science, geographic information systems (GIS), and cartographic visualization provide important concepts, methods, and tools equipping public health scientists to examine, characterize, and analyze the important relationship between our health and the places of our lives. As part of its work, GRASP has proposed and is shaping a framework, the Geospatial Determinants of Health (GDOH), that articulates the many and varied geospatial drivers that influence disease prevalence and promote health. The GDOH are at work in multiple environments where we experience health, including the natural environment, built environment, population connectivity environment, social and behavioral environment, and health policy environment.

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