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Environmental Health PHGKB

Specific PHGKB|Environmental Health PHGKB|PHGKB

Last Posted: Mar 29, 2023
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Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.
Nick Shrine et al. Nature genetics 2023 3 (3) 410-422

Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 580,869 participants, we identified 1,020 independent association signals implicating 559 genes supported by =2 criteria from a systematic variant-to-gene mapping framework. These genes were enriched in 29 pathways. Individual variants showed heterogeneity across ancestries, age and smoking groups, and collectively as a genetic risk score showed strong association with COPD across ancestry groups.

Host genomics for better infectious disease treatment
H Carr, PHG Foundation, March 6, 2023

Individuals can respond very differently to the same infectious disease, even when they have similar characteristics, comorbidities, and environmental exposures. Host genomics is the field that looks for genetic differences that help to explain the variations in response at certain points of an infection. While the COVID-19 pandemic significantly raised the profile of host genomics as a tool to better understand severe COVID-19, before the pandemic, scientists had been exploring host genomics to understand differences in host response to various infectious diseases.

The Potential Contribution of Cancer Genomics Information to Community Investigations of Unusual Patterns of Cancer: A Workshop
NASEM Workshop, April 13, 2023

The National Academies of Sciences, Engineering, and Medicine will hold a virtual, 1-day public workshop on the Potential Contribution of Cancer Genomics Information to Community Investigations of Unusual Patterns of Cancer on April 13, 2023 to explore the state of the science with regard to the identification of genomic and epigenomic biomarkers of environmental exposures associated with cancers, with emphasis on pediatric cancers.

Refining epigenetic prediction of chronological and biological age
E Bernabeau et al, Genome Medicine, February 28, 2023

Epigenetic clocks can track both chronological age (cAge) and biological age (bAge). The latter is typically defined by physiological biomarkers and risk of adverse health outcomes, including all-cause mortality. As cohort sample sizes increase, estimates of cAge and bAge become more precise. Here, we aim to develop accurate epigenetic predictors of cAge and bAge, while improving our understanding of their epigenomic architecture.


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MTMC-AUR2CNet: Multi-textural multi-class attention recurrent residual convolutional neural network for COVID-19 classification using chest X-ray images. External Web Site Icon
Gopatoti Anandbabu, et al. Biomedical signal processing and control 2023 0 0. 104857
Deep learning enables MV-based real-time image guided radiation therapy for prostate cancer patients. External Web Site Icon
Danielle Maria Chrystall et al. Physics in medicine and biology 2023
Patient and ward related risk factors in a multi-ward nosocomial outbreak of COVID-19: Outbreak investigation and matched case-control study. External Web Site Icon
Jenine Leal et al. Antimicrobial resistance and infection control 2023 3 (1) 21
Scalable RT-LAMP-based SARS-CoV-2 testing for infection surveillance with applications in pandemic preparedness. External Web Site Icon
Dan Lou et al. EMBO reports 2023 3 e57162
Comparison of the methods for isolation and detection of SARS-CoV-2 RNA in municipal wastewater. External Web Site Icon
Lucansky Vincent, et al. Frontiers in public health 2023 0 0. 1116636
Role of OAS gene family in COVID-19 induced heart failure. External Web Site Icon
Gao Li-Juan, et al. Journal of translational medicine 2023 0 0. (1) 212
Fully-automated sarcopenia assessment in head and neck cancer: development and external validation of a deep learning pipeline. External Web Site Icon
Zezhong Ye et al. medRxiv : the preprint server for health sciences 2023
Adjuvant durvalumab after concurrent chemoradiotherapy for patients with unresectable stage III NSCLC harbouring uncommon genomic alterations. External Web Site Icon
Francesco Cortiula et al. European journal of cancer (Oxford, England : 1990) 2023 184172-178
[Viral diseases of the nervous system-Selected new and old viruses]. External Web Site Icon
Meyding-Lamadé Uta, et al. Der Nervenarzt 2023 0 0.
Improved Decision Making for Water Lead Testing in U.S. Child Care Facilities Using Machine-Learned Bayesian Networks. External Web Site Icon
Riley E Mulhern et al. Environmental science & technology 2023

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Disclaimer: Articles listed in the Public Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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