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Environmental Health PHGKB

Specific PHGKB|Environmental Health PHGKB|Public Health Genomics and Precision Health Knowledge Base (PHGKB)
Effective August 1, 2024, this database will be discontinued. All content will remain searchable and be preserved online for historical purposes only until 2029.

Last Posted: Jul 25, 2024
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Precision public health in the era of genomics and big data
(Posted Jul 11, 2024 2PM)

From the abstract: "Precision public health (PPH) considers the interplay between genetics, lifestyle and the environment to improve disease prevention, diagnosis and treatment on a population level—thereby delivering the right interventions to the right populations at the right time. In this Review, we explore the concept of PPH as the next generation of public health. We discuss the historical context of using individual-level data in public health interventions and examine recent advancements in how data from human and pathogen genomics and social, behavioral and environmental research, as well as artificial intelligence, have transformed public health. "

Connecting lab, clinic, and community
(Posted Jul 08, 2024 8AM)

From the article: "To better understand relationships between the genes we inherit and the environmental and societal factors that surround us and to deliver more evidence-driven health care, research must be integrated into clinical care and community settings, reaching patients from all walks of life. Unlike most research settings, primary care is patient- and community-centered and emphasizes health maintenance and preventive care alongside treatment and rehabilitation in a location as convenient as possible for the patient. "

Gene–environment interactions in human health
(Posted May 29, 2024 9AM)

From the abstract: "Gene–environment interactions (G×E), the interplay of genetic variation with environmental factors, have a pivotal impact on human complex traits and diseases. Statistically, G×E can be assessed by determining the deviation from expectation of predictive models based solely on the phenotypic effects of genetics or environmental exposures. Despite the unprecedented, widespread and diverse use of G×E analytical frameworks, heterogeneity in their application and reporting hinders their applicability in public health. "

Placental DNA methylation signatures of prenatal air pollution exposure and potential effects on birth outcomes: an analysis of three prospective cohorts
(Posted May 09, 2024 6PM)

From the abstract: "Pregnancy air pollution exposure (PAPE) has been linked to a wide range of adverse birth and childhood outcomes, but there is a paucity of data on its influence on the placental epigenome, which can regulate the programming of physiological functions and affect child development. This study aimed to investigate the association between prenatal air pollutant exposure concentrations and changes in placental DNA methylation patterns, and to explore the potential windows of susceptibility and sex-specific alterations. "


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BARIATRIC SURGERIES IN THE BRAZILIAN PUBLIC HEALTH SYSTEM FROM 2012 TO 2022: DESCRIPTIVE STUDY OF HOSPITALIZATIONS IN THE STATE OF PARANÁ. External Web Site Icon
Fahs Hassan Ali, et al. Arquivos de gastroenterologia 2024 0 0. e24009
Infective SARS-CoV-2 in Skull Sawdust at Autopsy, Finland. External Web Site Icon
Kantonen Jonas N, et al. Emerging infectious diseases 2024 0 0. (8) 1735-1737
A natural ANI gap that can define intra-species units of bacteriophages and other viruses. External Web Site Icon
Aldeguer-Riquelme Borja, et al. mBio 2024 0 0. e0153624
Confounding amplifies the effect of environmental factors on COVID-19. External Web Site Icon
Hao Zihan, et al. Infectious Disease Modelling 2024 0 0. (4) 1163-1174
Biofluid specific protein coronas affect lipid nanoparticle behavior in vitro. External Web Site Icon
van Straten Demian, et al. Journal of controlled release : official journal of the Controlled Release Society 2024 0 0.
Blood DNA methylation in post-acute sequelae of COVID-19 (PASC): a prospective cohort study. External Web Site Icon
Balnis Joseph, et al. EBioMedicine 2024 0 0. 105251
Deep IDA: a deep learning approach for integrative discriminant analysis of multi-omics data with feature ranking-an application to COVID-19. External Web Site Icon
Wang Jiuzhou, et al. Bioinformatics advances 2024 0 0. (1) vbae060
Single cell multi-omic analysis identifies key genes differentially expressed in innate lymphoid cells from COVID-19 patients. External Web Site Icon
Kaushik Abhinav, et al. Frontiers in immunology 2024 0 0. 1374828
Spatiotemporal dynamics of epidemiology diseases: mobility based risk and short-term prediction modeling of COVID-19. External Web Site Icon
Silva Melissa, et al. Frontiers in public health 2024 0 0. 1359167
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods. External Web Site Icon
Mesinovic Munib, et al. Scientific reports 2024 0 0. (1) 16387

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About EH PHGKB

Environmental Health PHGKB is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other materials that address the use of genomic and other precision health technologies in addressing environmental health issues including epidemiology, translation, policies and guidelines and population health programs and impact...more

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Disclaimer: Articles listed in the Public Health Knowledge Base are selected by Public Health Genomics Branch to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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