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Last Posted: Jan-25-2022 13:31:43

Carditis After COVID-19 Vaccination With a Messenger RNA Vaccine and an Inactivated Virus VaccineFREE A Case–Control Study
TTT Lai et al, Ann Int Med, January 25, 2022

A total of 160 case patients and 1533 control participants were included. Incidence of carditis per 100 000 doses of CoronaVac and BNT162b2 administered was estimated to be 0.31 (95% CI, 0.13 to 0.66) and 0.57 (CI, 0.36 to 0.90), respectively. Multivariable analyses showed that recipients of the BNT162b2 vaccine had higher odds of carditis (adjusted odds ratio [OR], 3.57 [CI, 1.93 to 6.60]) than unvaccinated persons. Stratified by sex, the OR was 4.68 (CI, 2.25 to 9.71) for males and 2.22 (CI, 0.57 to 8.69) for females receiving the BNT162b2 vaccine. The ORs for adults and adolescents receiving the BNT162b2 vaccine were 2.41 (CI, 1.18 to 4.90) and 13.79 (CI, 2.86 to 110.38), respectively.

Myocarditis Cases Reported After mRNA-Based COVID-19 Vaccination in the US From December 2020 to August 2021
ME Oster et al, JAMA< January 25, 2022

In this descriptive study of 1626 cases of myocarditis in a national passive reporting system, the crude reporting rates within 7 days after vaccination exceeded the expected rates across multiple age and sex strata. The rates of myocarditis cases were highest after the second vaccination dose in adolescent males aged 12 to 15 years (70.7 per million doses of the BNT162b2 vaccine), in adolescent males aged 16 to 17 years (105.9 per million doses of the BNT162b2 vaccine), and in young men aged 18 to 24 years (52.4 and 56.3 per million doses of the BNT162b2 vaccine and the mRNA-1273 vaccine, respectively).

Trends in Disease Severity and Health Care Utilization During the Early Omicron Variant Period Compared with Previous SARS-CoV-2 High Transmission Periods — United States, December 2020–January 2022
AD Luliano et al, MMWR, January 25, 2022

The SARS-CoV-2 B.1.1.529 (Omicron) variant became predominant in the United States by late December 2021, leading to a surge in COVID-19 cases and associated ED visits and hospitalizations. Despite Omicron seeing the highest reported numbers of COVID-19 cases and hospitalizations during the pandemic, disease severity indicators, including length of stay, ICU admission, and death, were lower than during previous pandemic peaks.

Preventing SARS-CoV-2 Transmission in Health Care Settings in the Context of the Omicron Variant.
Klompas Michael et al. JAMA 2022 1

Several measures work in conjunction in the hierarchy of infection control. No one measure is perfect. But by improving administrative controls (vaccinations and testing), engineering controls (ventilation and filtration), and personal protective equipment (better respiratory protection), transmission of the Omicron variant can be substantially reduced. This is of particular urgency because Omicron outbreaks in hospitals further exacerbate critical staff shortages and threaten hospitals’ capacity to accommodate the unprecedented surge in inpatient admissions.

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