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Last Posted: Feb-09-2023 06:36:42

Liquid Biopsy for Oral Cancer Diagnosis: Recent Advances and Challenges
Y Naito et al, J Per Med, February 8, 2023

Over the past two decades, liquid biopsy has been considered an attractive diagnostic tool for malignant tumors. Although biomarkers for oral cancer have not yet been adopted in clinical practice, many molecular candidates have been investigated for liquid biopsies in oral cancer diagnosis, such as the proteome, metabolome, microRNAome, extracellular vesicles, cell-free DNAs, and circulating tumor cells. This review will present recent advances and challenges in liquid biopsy for oral cancer diagnosis.

How rare mutations contribute to complex traits
LM Evans et al, Nature, February 8, 2023

Our understanding of the genetic mutations that affect complex human traits — such as height, smoking-related behaviour or the risk of diabetes — has been vastly broadened by genome-wide association studies (GWASs). But such research has focused largely on associations between traits of interest and variants that are common in the human population. Rare variants pose challenges to GWASs, because they can be studied using only large samples and in-depth genetic information, and can be more strongly confounded by non-genetic factors than can common variants,

Use of wastewater metrics to track COVID-19 in the U.S.: a national time-series analysis over the first three quarters of 2022
M Varkila et al, MEDRXIV, February 8, 2023

Among 268 counties across 22 states, wastewater percentile detected high reported case and hospitalizations rates in the first quarter of 2022 (AUC 0.95 and 0.86 respectively) whereas the percent change did not (AUC 0.54 and 0.49 respectively). A wastewater percentile of 51% maximized sensitivity (0.93) and specificity (0.82) for detecting high case rates.

Characterisation of SARS-CoV-2 variants in Beijing during 2022: an epidemiological and phylogenetic analysis
Y Pan et al, The Lancet, February 8, 2023

With soaring growth in the number of COVID-19 cases in China recently, there are concerns that there might be an emergence of novel SARS-CoV-2 variants. Routine surveillance of viral genomes has been carried out in Beijing over the last 3 years. From Nov 14 to Dec 20, we sequenced 413 new samples, including 350 local cases and 63 imported cases. All of these genomes belong to the existing 123 Pango lineages, showing there are no persistently dominant variants or novel lineages.

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