Impact of genetic ancestry on viral infection response
L Koch, Nat Rev Genetics, November 29, 2021
Pathogens impose selection pressures on human genomes. Depending on local environments, over time this pressure may lead to population-specific genetic variation that differentially affects infectious disease susceptibility. A recent study sought to characterize the genetic determinants of differences in immune responses to viral infection between individuals of European and African ancestries.
Show us the Data: Global COVID-19 Wastewater Monitoring Efforts, Equity, and Gaps
CC Naughton et al, MEDRXIV, November 28, 2021
Unlike COVID-19 case and mortality data, there was not a global dashboard to track wastewater monitoring of SARS-CoV-2 RNA worldwide. This study provides a one year review of the COVIDPoops19 global dashboard of universities, sites, and countries monitoring SARS-CoV-2 RNA in wastewater. Methods to assemble the dashboard combined standard literature review, direct submissions, and daily, social media keyword searches. Over 200 universities, 1,000 sites, and 55 countries with 59 dashboards monitor wastewater for SARS-CoV-2 RNA. However, monitoring is primarily in high-income countries (65 percent) with less access to this valuable tool in low and middle income countries (35 percent).
An equation for equity- New equations to estimate kidney function enable accurate clinical assessment without the use of race as a modifier.
K O'Leary, Nature Medicine, November 25, 2021
Two studies generated new equations for estimated GFR that do not incorporate race. Through similar approaches, both studies found that equations that did not include race but incorporated cystatin C (alone or with creatinine) had a high level of accuracy. Validation and consistent implementation of new equations that do not incorporate race will be key to providing optimal patient care.
Vax the world
M Pai et al, Science, November 25, 2021
Consider the social and economic consequences of vaccine inequity. In 2020, the pandemic led to nearly 100 million more people in poverty, and the UN estimates that developing countries will suffer economic losses of $12 trillion through 2025. This will only get worse, as SARS-CoV-2 (Delta variant) is now primarily affecting countries with low vaccine coverage.
Latest News and Publications
Changes Over Time in COVID-19 Vaccination Inequalities in Eight Large U.S. Cities
SM Gaddis et al, MEDRXIV, December 2, 2021
Exploring the Temporal Dynamics of County-Level Vulnerability Factors on COVID-19 Outcomes
J Zhang et al, MEDRXIV, November 26, 2021
Pandemic inequity in a megacity: a multilevel analysis of individual, community, and health care vulnerability risks for COVID-19 mortality in Jakarta, Indonesia
H Surendra et al, MEDRXIV, November 26, 2021
A Time Series Analysis and Predictive Modeling of COVID-19 Impacts in the African American Community
T Oladunni et al, MEDRXIV, November 6, 2021
Analysis of Sociodemographic, Clinical, and Genomic Factors Associated With Breast Cancer Mortality in the Linked Surveillance, Epidemiology, and End Results and Medicare Database.
Robinson Timothy J et al. JAMA network open 2021 4(10) e2131020
COVID-19 vaccines inequity and hesitancy among African Americans.
Sina-Odunsi Ayobami Jadesola, et al. Clinical epidemiology and global health 2021 0 0. 100876
Can Studying Genetically Predisposed Individuals Inform Prevention Strategies for RA?
Fowler-Woods Amanda et al. Healthcare (Basel, Switzerland) 2021 9(10)
Pioneering BRCA1/2 Point-Of-Care Testing for Integration of Germline and Tumor Genetics in Breast Cancer Risk Management: A Vision for the Future of Translational Pharmacogenomics.
Mampunye Lwando et al. Frontiers in oncology 2021 11619817
SARS-CoV-2 sequencing collaboration in west Africa shows best practices.
Onwuamah Chika Kingsley et al. The Lancet. Global health 2021 10 (11) e1499-e1500
The air quality changes and related mortality benefits during the coronavirus disease 2019 pandemic in China: Results from a nationwide forecasting study.
Qiu Weihong, et al. Journal of cleaner production 2021 0 0. 127327