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Health Equity PHGKB

Specific PHGKB|Health Equity PHGKB|Public Health Genomics and Precision Health Knowledge Base (PHGKB)
Effective August 1, 2024, this database was discontinued. All content will remain searchable and be preserved online for historical purposes only until 2029.

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Expanded Newborn Screening Using Genome Sequencing for Early Actionable Conditions

From the abstract: "What is the parental acceptance, feasibility, and screen-positive rate of targeted genome screening in newborns of different racial and ethnic groups? In this study of 4000 newborns, 72.0% of approached families consented to participate. Genome sequencing was successfully completed for 99.6% of participants. The screen-positive rate in a predefined gene panel was 3.7%. Targeted analysis of a predefined set of genes from genome sequencing for screening in a diverse newborn population is feasible and could expand the scope of newborn screening. "

Crossing the Equity Chasm: Addressing a Second Valley of Death in Biomedical Innovation

From the article: "Recent transformative advances in health and medicine have successfully traversed the valley of death, including progress in genomics, precision medicine, innovative medicines and vaccines, gene therapy, and artificial intelligence. However, it is critical to call attention to a second, important valley of death: the failure to deliver scientific advances to populations most in need. The second valley of death is fueled by socioeconomic, environmental, political, and systemic factors; health system failures; and persistent challenges in closing the last mile in health care, resulting in significant disparities in morbidity and mortality worldwide. "

Advancing ASO therapies from development to implementation

From the abstract: "A novel application of antisense oligonucleotide (ASO) technology, developed to treat a single patient, adds to the growing number of ‘personalized’ therapies for rare diseases; but pathways to implementation and access are urgently needed. "

Every baby deserves access to genetic screening

From the article: "Nation-wide genetic screening, available to all newborns, could in principle also be a tool to narrow the disparities that exist in today’s healthcare systems, providing to every family information about their baby’s health, regardless of socioeconomic and geographical factors. Designing genomics-based newborn screening programs that bring benefit equitably to the population is, however, an extremely complex task, also given the costs, and there is an urgent need to generate robust evidence on the potential benefits and harms of the approach, at the population level, before it can be implemented more widely. "


news Latest News and Publications
Challenges and opportunities of vaccination during pregnancy: perspectives of 20 healthcare professionals. External Web Site Icon
Razai Mohammad S, et al. Journal of public health policy 2025 0 0.
The impact of remdesivir on SARS-CoV-2 evolution in vivo. External Web Site Icon
Ling-Hu Ted, et al. JCI insight 2025 0 0.
Assessing Health Disparities in Digital Services and Technologies During and After the COVID-19 Pandemic: A Pooled Cross-Sectional Analysis Using HINTS Data. External Web Site Icon
Shih Huan-Ju, et al. Patient preference and adherence 2025 0 0. 87-96
Prevalence and risk factors for long COVID in China: A systematic review and meta-analysis of observational studies. External Web Site Icon
Hu Le-Yan, et al. Journal of infection and public health 2025 0 0. (3) 102652
Mitigating bias in AI mortality predictions for minority populations: a transfer learning approach. External Web Site Icon
Gu Tianshu, et al. BMC medical informatics and decision making 2025 0 0. (1) 30
Burden of death associated with SARS-CoV-2 infection during the pandemic in Flint, Michigan (MI), mortality trends over the 2-year period: impact of social and health inequities. External Web Site Icon
Younas Mariam, et al. Antimicrobial stewardship & healthcare epidemiology : ASHE 2025 0 0. (1) e110
Parental Factors Associated With Measles-Mumps-Rubella Vaccination in US Children Younger Than 5 Years. External Web Site Icon
Zhou Eric Geng, et al. American journal of public health 2025 0 0. e1-e5
Predictive modelling and identification of critical variables of mortality risk in COVID-19 patients. External Web Site Icon
Daramola Olawande, et al. Scientific reports 2025 0 0. (1) 2184
Assessment of clinical characteristics and mortality in patients hospitalized with SARS-CoV-2 from January 2022 to November 2022, when Omicron variants were predominant in the United States. External Web Site Icon
Scott Amie, et al. Current medical research and opinion 2025 0 0. 1-17
The effects of deprivation, age, and regional differences in COVID-19 mortality from 2020 to 2022: a retrospective analysis of public provincial data. External Web Site Icon
Chen Anqi A, et al. BMC public health 2025 0 0. (1) 148

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About Health Equity PHGKB

Health Equity PHGKB is an online, continuously updated, searchable database of genomics and precision health information and publications relevant to health equity...more

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Disclaimer: Articles listed in the Public Health Knowledge Base are selected by Public Health Genomics Branch to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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