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Health Equity PHGKB

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Last Posted: May 18, 2022
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Priority COVID-19 Public Health Science Questions
CDC, May 17, 2022

It remains important to collect data-driven information on key priority areas that can help CDC and public health partners continue to fill critical scientific gaps, build on knowledge gained and advances made, and inform evidence-based decision-making for continued intervention through public health surveillance and epidemiologic research. CDC has developed priority questions around 8 thematic topic areas for The CDC Public Health Science Agenda for COVID-19: health equity, vaccines, variants, prevention, testing, treatment, natural history and post-COVID conditions.

Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.
Mahajan Anubha et al. Nature genetics 2022 5 (5) 560-572

We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 × 10-9), which were delineated to 338 distinct association signals. Fine-mapping of these signals was enhanced by the increased sample size and expanded population diversity of the multi-ancestry meta-analysis, which localized 54.4% of T2D associations to a single variant with >50% posterior probability

Pregnant Latinas’ views of adopting exome sequencing into newborn screening: A qualitative study
H Wang et al, Genetics in Medicine, May 17, 2022

We conducted semistructured interviews with 32 pregnant Latinas who predominately lived in rural areas and had low levels of income and education. An emergent coding approach was used to analyze the qualitative data collected. Our entire sample believed that ES should be offered as a part of newborn screening, which could empower pregnant Latinas to better understand their children’s health and take early treatment actions. Although some participants were concerned about potentially bad ES results and had questions about the accuracy of ES results, nearly all interviewees reported that they would be willing to have their newborns undergo ES. The main reasons given were to be informed of diseases that the baby may have, and the perception that ES is a procedure that involves minimal risk.

Genomic outbreak surveillance in resource-poor settings
L Musila, Nat Rev Genetics, May 16m 2022

The SARS-CoV-2 pandemic fueled massive growth in sequencing capability, with more countries beginning to conduct routine genomic epidemiological surveillance, mainly because of the accessibility and ease of use of portable nanopore sequencers. But we should not wait for the next pandemic to achieve full genomic equity, enabled by the end-to-end capability to sequence and analyze genomic data for public health in under-resourced settings!


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Genomic outbreak surveillance in resource-poor settings External Web Site Icon
L Musila, Nat Rev Genetics, May 16m 2022
Priority COVID-19 Public Health Science Questions
CDC, May 17, 2022
SARS-CoV-2 Susceptibility and ACE2 Gene Variations Within Diverse Ethnic Backgrounds. External Web Site Icon
Vadgama Nirmal, et al. Frontiers in genetics 2022 0 0. 888025
Social Determinants of Health Factors for Gene-Environment COVID-19 Research: Challenges and Opportunities. External Web Site Icon
Phuong Jimmy, et al. Advanced genetics (Hoboken, N.J.) 2022 0 0. 2100056
A new approach for determining SARS-CoV-2 epitopes using machine learning-based in silico methods. External Web Site Icon
Cihan Pinar, et al. Computational biology and chemistry 2022 0 0. 107688
Algorithmic fairness in pandemic forecasting: lessons from COVID-19. External Web Site Icon
Tsai Thomas C, et al. NPJ digital medicine 2022 0 0. (1) 59
An ecological modeling on the adjusted effects of socioeconomic determinants and HLA-DRB1 alleles in fatality of COVID-19 during the early phase of epidemics in a group of countries. External Web Site Icon
Yasin Ahmadi Seyyed Amir, et al. Przeglad epidemiologiczny 2022 0 0. (4) 471-483
Who was at risk for COVID-19 late in the US pandemic? Insights from a population health machine learning model. External Web Site Icon
Adeoye Elijah A, et al. Medical & biological engineering & computing 2022 0 0.
Assessing the impacts of timing on the health benefits, cost-effectiveness and relative affordability of COVID-19 vaccination programmes in 27 African Countries External Web Site Icon
Y Liu et al, MEDRXIV, May 10, 2022
Socioeconomic inequality in SARS-CoV-2 testing and COVID-19 outcomes in UK Biobank over the first year of the pandemic: can inequalities be explained by selection bias? External Web Site Icon
AR Carter et al, MEDRXIV, May 5, 2022

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About Health Equity PHGKB

Health Equity PHGKB is an online, continuously updated, searchable database of genomics and precision health information and publications relevant to health equity...more

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Disclaimer: Articles listed in the Public Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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