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Health Equity PHGKB

Specific PHGKB|Health Equity PHGKB|PHGKB

Last Posted: Aug 04, 2022
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Disparities in distribution of COVID-19 vaccines across US counties: A geographic information system-based cross-sectional study.
Hernandez Inmaculada et al. PLoS medicine 2022 7 (7) e1004069

Equity in the distribution of Coronavirus Disease 2019 (COVID-19) vaccine is of major relevance. It is unknown whether there were differences in the distribution of COVID-19 vaccines to healthcare facilities depending on the demographic composition of the population. What did the researchers do and find? We tested whether healthcare facilities serving minority or disadvantaged neighborhoods were less likely to administer COVID-19 vaccines in the early phase of the COVID-19 vaccine rollout process. We found that healthcare facilities in counties with higher Black composition, in rural areas, and in hardest-hit communities were less likely to administer COVID-19 vaccines in May 2021.

Improving access to genetic services for underserved populations: Amish, Mennonite, and other Plain communities
A Kantipuly et al, CDC Blog Post, August 3, 2022

Lack of access to genetic services in rural areas could contribute to disparities in quality of care, but tailored approaches can overcome some barriers and improve care. Here we present the example of the Midwest Genetics Network (MGN) outreach with the Plain communities.

Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer
J Byun et al, Nature Genetics, August 1, 2022

To identify new susceptibility loci to lung cancer among diverse populations, we performed cross-ancestry genome-wide association studies in European, East Asian and African populations and discovered five loci that have not been previously reported. We replicated 26 signals and identified 10 new lead associations from previously reported loci. Rare-variant associations tended to be specific to populations, but even common-variant associations influencing smoking behavior, such as those with CHRNA5 and CYP2A6, showed population specificity.

CFTR genotype analysis of Asians in international registries highlights disparities in the diagnosis and treatment of Asian patients with cystic fibrosis.
Vaidyanathan Sriram et al. Genetics in medicine : official journal of the American College of Medical Genetics 2022 7

Cystic fibrosis (CF) is not well-characterized in Asians, potentially resulting in delayed diagnosis and poor prognosis. We characterized CF in Asian subgroups to address these disparities. The prevalence of CF was 1 in 74,982 people (Canada) to 1 in 13,340 people (United Kingdom) for South Asians and 1 in 256,541 (Canada) to 1 in 52,563 (United Kingdom) for other Asians, suggesting 26,000 to 146,000 patients with CF in South Asia. p.(F508del) variant was markedly less frequent in Asians than in non-Hispanic Whites. Splicing and nonsense variants occurred at high allelic frequencies in Asians, resulting in 41% to 49% of South Asians and 21% to 39% of other Asians being ineligible for CFTR modulator therapies. Hologic/EU2v1 panels failed to identify 37% to 47% of South Asian and 23% to 46% of other Asian patients with CF.


news Latest News and Publications
Disparities in distribution of COVID-19 vaccines across US counties: A geographic information system-based cross-sectional study. External Web Site Icon
Hernandez Inmaculada et al. PLoS medicine 2022 7 (7) e1004069
Improving performance of classifiers for diagnosis of critical diseases to prevent COVID risk. External Web Site Icon
Kumar Vinod, et al. Computers & electrical engineering : an international journal 2022 0 0. 108236
Geographic microtargeting of social assistance with high-resolution poverty maps. External Web Site Icon
Smythe Isabella S, et al. Proceedings of the National Academy of Sciences of the United States of America 2022 0 0. (32) e2120025119
Predicting death risk analysis in fully vaccinated people using novel extreme regression-voting classifier. External Web Site Icon
Saad Eysha, et al. Digital health 2022 0 0. 20552076221109530
Human ACE2 Polymorphisms from Different Human Populations Modulate SARS-CoV-2 Infection. External Web Site Icon
Hu Pan, et al. Viruses 2022 0 0. (7)
Predictors of the Third (Booster) Dose of COVID-19 Vaccine Intention among the Healthcare Workers in Saudi Arabia: An Online Cross-Sectional Survey. External Web Site Icon
Alobaidi Sami, et al. Vaccines 2022 0 0. (7)
Telemedicine and virtual respiratory care in the era of COVID-19. External Web Site Icon
Pinnock Hilary, et al. ERJ open research 2022 0 0. (3)
Immunogenicity of BNT162b2 COVID-19 vaccine in New Zealand adults. External Web Site Icon
Priddy Frances H, et al. Vaccine 2022 0 0.
Pre-Clinical Development of a Potent Neutralizing Antibody MW3321 With Extensive SARS-CoV-2 Variants Coverage. External Web Site Icon
Jiang Wen, et al. Frontiers in pharmacology 2022 0 0. 926750
Bias in algorithms of AI systems developed for COVID-19: A scoping review. External Web Site Icon
Delgado Janet, et al. Journal of bioethical inquiry 2022 0 0.

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Disclaimer: Articles listed in the Public Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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