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HLBS PHGKB

Specific PHGKB|HLBS|Public Health Genomics and Precision Health Knowledge Base (PHGKB)
Effective August 1, 2024, this database was discontinued. All content will remain searchable and be preserved online for historical purposes only until 2029.

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A roadmap for affordable genetic medicines

From the abstract: "Nineteen genetic therapies have been approved by the U.S. Food and Drug Administration (FDA) to date, a number that now includes the first CRISPR genome editing therapy for sickle cell disease, CASGEVY (exagamglogene autotemcel). This extraordinary milestone is widely celebrated because of the promise for future genome editing treatments of previously intractable genetic disorders and cancers. At the same time, such genetic therapies are the most expensive drugs on the market, with list prices exceeding $4 million per patient. "

Efanesoctocog Alfa Prophylaxis for Children with Severe Hemophilia A

From the abstract: "In children with severe hemophilia A, once-weekly prophylaxis with efanesoctocog alfa provided high sustained factor VIII activity in the normal to near-normal range (>40 IU per deciliter) for 3 days and more than 10 IU per deciliter for almost 7 days after administration, leading to effective bleeding prevention. Efanesoctocog alfa was associated with mainly nonserious adverse events. "

Improving the Detection of Potential Cases of Familial Hypercholesterolemia: Could Machine Learning Be Part of the Solution?

From the abstract: "Familial hypercholesterolemia (FH), while highly prevalent, is a significantly underdiagnosed monogenic disorder. Improved detection could reduce the large number of cardiovascular events attributable to poor case finding. We aimed to assess whether machine learning algorithms outperform clinical diagnostic criteria (signs, history, and biomarkers) and the recommended screening criteria in the United Kingdom in identifying individuals with FH-causing variants, presenting a scalable screening criteria for general populations. "

Exceptional Genetics, Generalizable Therapeutics, and Coronary Artery Disease

From the article: "The increasingly widespread availability of genomic sequencing has enabled the identification of persons and families with uniquely favorable traits, including a very low incidence of clinical events. Such exceptional persons across diverse communities are playing an important role in the genesis of medicines for common cardiovascular diseases. "


news Latest News and Publications
Cause of Death Analysis in a 9½-Year-Old with COVID-19 and Dravet Syndrome. External Web Site Icon
Meher Vedashree R, et al. Pathophysiology : the official journal of the International Society for Pathophysiology 2025 0 0. (1)
Exosomes derived from syncytia induced by SARS-2-S promote the proliferation and metastasis of hepatocellular carcinoma cells. External Web Site Icon
Li Huilong, et al. Frontiers in cellular and infection microbiology 2025 0 0. 1415356
The monogenic landscape of human infectious diseases. External Web Site Icon
Boisson-Dupuis Stéphanie, et al. The Journal of allergy and clinical immunology 2024 0 0.
Safety of two-dose schedule of COVID-19 adsorbed inactivated vaccine (CoronaVac; Sinovac/Butantan) and heterologous additional doses of mRNA BNT162b2 (Pfizer/BioNTech) in immunocompromised and immunocompetent individuals. External Web Site Icon
Miyaji Karina Takesaki, et al. Revista do Instituto de Medicina Tropical de Sao Paulo 2025 0 0. e2
Role of IPF genetic risk loci in post-COVID-19 lung abnormalities: a cohort study. External Web Site Icon
Marinescu Daniel-Costin, et al. BMJ open respiratory research 2025 0 0. (1)
Characteristics and Associated Factors of Insomnia Among the General Population in the Post-Pandemic Era of COVID-19 in Zhejiang, China: A Cross-Sectional Study. External Web Site Icon
Da Miao, et al. International journal of general medicine 2025 0 0. 191-206
Comparative Analysis of COVID-19 Severity and Mortality Among Vaccinated and Unvaccinated Individuals During the Delta Variant Surge in a Tertiary Care Center: A Cohort Study. External Web Site Icon
Hasani Fatemeh, et al. Health science reports 2025 0 0. (1) e70346
Automatic detection and prediction of COVID-19 in cough audio signals using coronavirus herd immunity optimizer algorithm. External Web Site Icon
Ayappan G, et al. Scientific reports 2025 0 0. (1) 2271
COVID-19 Symptoms Only Minutely Influenced by Genes Among Children in a Nationwide Twin Cohort. External Web Site Icon
Hedman Anna M, et al. The Pediatric infectious disease journal 2025 0 0.
Predictive modelling and identification of critical variables of mortality risk in COVID-19 patients. External Web Site Icon
Daramola Olawande, et al. Scientific reports 2025 0 0. (1) 2184

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About HLBS-PopOmics

HLBS-PopOmics is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other materials that address the translation of genomic and other precision health discoveries into improved health care and prevention related to Heart and Vascular Diseases(H), Lung Diseases(L), Blood Diseases(B), and Sleep Disorders(S)...more

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Site Citation:
Mensah GA, Yu W, Barfield WL, Clyne M, Engelgau MM, Khoury MJ. HLBS-PopOmics: an online knowledge base to accelerate dissemination and implementation of research advances in population genomics to reduce the burden of heart, lung, blood, and sleep disorders. Genet Med. 2018 Sep 10. doi: 10.1038/s41436-018-0118-1

Disclaimer: Articles listed in the Public Health Knowledge Base are selected by Public Health Genomics Branch to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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