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Family Health History PHGKB

Specific PHGKB|Family Health History PHGKB|PHGKB

Last Posted: Sep 16, 2023
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How to Talk to Your Family About Their Heart Health History Even if you’re not super close to your relatives, you’ve got options.
K Miller, Self, September 2023

From the website: "If someone in your bio family has heart problems, don’t freak out: It doesn’t mean that you’ll automatically develop them too. Yes, that does increase your risk of developing an issue—but there are loads of other factors that might be meaningful, and this genetic link is just one part of a fuller picture. Bring any information you turn up to a primary care physician first (if you’re not already seeing a specialist): Depending on what you share, your PCP might refer you to a cardiologist who can take a closer look at your overall health, as well as any symptoms that could be indicative of a larger cardiovascular issue. "

Assessing a Polygenic Risk Score for Lung Cancer Susceptibility in Non-Hispanic White and Black Populations.
Matthew R Trendowski et al. Cancer Epidemiol Biomarkers Prev 2023 8

Polygenic risk scores (PRS) have become an increasingly popular approach to evaluate cancer susceptibility, but have not adequately represented Black populations in model development. Methods: We used a previously published lung cancer PRS based on 80 SNPs associated with lung cancer risk in the OncoArray cohort and validated in UK Biobank. The PRS was evaluated for association with lung cancer risk adjusting for age, sex, total pack-years, family history of lung cancer, history of COPD, and the top five principal components for genetic ancestry.

Are You Up to Date on Your Preventive Care?
CDC, July 2023

Family health history is a record of the diseases and health conditions in your family. You and your family members share genes. You may also have behaviors in common, like what you do for physical activity and what you like to eat. You may live in the same area and come into contact with similar harmful things in the environment. Family history includes all of these factors, any of which can affect your health. If you have a family history of a chronic disease, like cancer, heart disease, diabetes, or osteoporosis, you’re more likely to get that disease yourself.

Your Family Connects: A Theory-Based Intervention to Encourage Communication About Possible Inherited Cancer Risk among Ovarian Cancer Survivors and Close Relatives
J Zhao et al, Public Health Genomics, July 25, 2023

Encouraging family communication about possible genetic risk has become among the most important avenues for achieving the full potential of genomic discovery for primary and secondary prevention. Yet, effective family-wide risk communication (i.e., conveying genetic risk status and its meaning for other family members) remains a critical gap in the field. We aim to describe the iterative process of developing a scalable population-based communication outreach intervention, Your Family Connects.


news Latest News and Publications
Machine learning-based diagnosis and risk classification of coronary artery disease using myocardial perfusion imaging SPECT: A radiomics study. External Web Site Icon
Mehdi Amini et al. Sci Rep 2023 13(1) 14920
Does the amount of family history matter? Perspectives of adult adoptees. External Web Site Icon
Alyssa Williams et al. J Genet Couns 2023
Refinement of the diagnostic approach for the identification of children and adolescents affected by familial hypercholesterolemia: Evidence from the LIPIGEN study. External Web Site Icon
Manuela Casula et al. Atherosclerosis 2023 117231
Same day service: A genetic testing station model to improve germline genetic testing in patients with ovarian cancer. External Web Site Icon
Nicole Marjon et al. Gynecol Oncol 2023 17753-59
An Interpretable Longitudinal Preeclampsia Risk Prediction Using Machine Learning. External Web Site Icon
Braden W Eberhard et al. medRxiv 2023
Advancing diagnosis and management of liver disease in adults through exome sequencing. External Web Site Icon
Melanie Zheng et al. EBioMedicine 2023 95104747
Factors affecting adherence to a high-risk surveillance protocol among patients with Li-Fraumeni syndrome. External Web Site Icon
Kaylee A Underkofler et al. Hered Cancer Clin Pract 2023 21(1) 15
Integrating a Polygenic Risk Score into a clinical setting would impact risk predictions in familial breast cancer. External Web Site Icon
Panagiotis Baliakas et al. J Med Genet 2023
Family History of Alzheimer's Disease Increases the Risk of COVID-19 Positivity: A SUMS Employees Cohort-based Study. External Web Site Icon
Masoumi Seyed Jalil, et al. Journal of biomedical physics & engineering 2023 0 0. (4) 363-366
Comparisons of the prediction models for undiagnosed diabetes between machine learning versus traditional statistical methods. External Web Site Icon
Seong Gyu Choi et al. Sci Rep 2023 13(1) 13101

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About Family Health History PHGKB

Family Health History PHGKB is an online, continuously updated, searchable database of information and publications relevant to the role of family health history in healthcare and disease prevention....more

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Disclaimer: Articles listed in the Public Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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