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Family Health History PHGKB

Specific PHGKB|Family Health History PHGKB|PHGKB

Last Posted: Nov 10, 2022
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Systematic comparison of family history and polygenic risk across 24 common diseases.
Mars Nina et al. American journal of human genetics 2022 11

Covering a large proportion of the burden of non-communicable diseases in adults, we show that family history and PRS are independent and not interchangeable measures, but instead provide complementary information on inherited disease susceptibility. The PRSs explained on average 10% of the effect of first-degree family history, and first-degree family history 3% of PRSs, and PRS effects were independent of both early- and late-onset family history. The PRS stratified the risk similarly in individuals with and without family history.

When It Comes to Breast Cancer, Sometimes It’s All in the Family
G Miller, CDC Cancer, Blog, October 2022

Has anyone ever told you that you have your mother’s eyes? Or that you look just like your grandmother? We all get our looks and physical traits from our families, but we may not always think about risks we share for diseases like cancer, including breast cancer. The good news is that knowing your family cancer history can give you a head start toward preventing breast cancer. No matter your gender, it’s important to know your risk and learn how to protect yourself.

Breast Cancer Awareness Month 2022 Digital Media Toolkit
CDC, October 5, 2022

In support of the national Breast Cancer Awareness Month October 2022 observance, the CDC Division of Cancer Prevention and Control will focus messaging and activities on finding cancer early, when it’s easiest to treat. Content and activities will be structured to empower people to take the steps needed to find breast cancer early, when it’s easiest to treat by: Knowing your risk for breast cancer; Knowing how you can lower your risk of breast cancer Knowing your family history; Knowing when to get a breast cancer screening; Knowing where to get a breast cancer screening

The Joint Public Health Impact of Family History of Diabetes and Cardiovascular Disease among Adults in the United States: A Population-Based Study
D Rasooly et al, Public Health Genomics, October 6, 2022

Participants with joint family history exhibit 6.5 greater odds for having both diseases and are diagnosed with diabetes 6.6 years earlier than participants without family history. Healthy participants without prevalent CVD or diabetes but with joint family history exhibit a greater prevalence of diabetes risk factors compared to no family history counterparts. Joint family history is associated with an increase in all-cause mortality. Over 44% of the US adult population has a family history of CVD and/or diabetes. This wide presence of high-risk family history suggests that clinical and public health efforts should collect and act on joint family history of CVD and diabetes to improve population efforts in the prevention and early detection of these common chronic diseases.


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Disclaimer: Articles listed in the Public Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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