About PHGKB
The CDC Public Health Genomics and Precision Health Knowledge Base (PHGKB) is an online, continuously updated, searchable database of published scientific literature, CDC resources, and other materials that address the translation of genomics and precision health discoveries into improved health care and disease prevention. The Knowledge Base is curated by CDC staff and is regularly updated to reflect ongoing developments in the field. This compendium of databases can be searched for genomics and precision health related information on any specific topic. We will continue to add additional features to the knowledge base and are interested in your feedback via email.
Database Content (Last Updated: Apr 27, 2024)
COVID-19 GPH
COVID-19 GPH is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other materials that captures emerging discoveries and applications of genomics, molecular and other precision medicine and precision public health tools in the investigation and control of COVID-19. Contents include PubMed records via an automated pubmed search algorithm, the relevant information picked by experts, and linkages to contents from our curated PHGKB databases.
CDC/NIH Web Information Database
This database includes general CDC and NIH public health information on specific diseases and health related topics. When available, the database displays genomic information from various CDC and NIH web pages. Users are also encouraged to conduct searches of CDC and NIH websites for additional information.
CDC-authored Genomics and Precision Health Publications Database
This database contains CDC-authored scientific publications on genomics and precision health-related topics, and includes articles on infectious diseases, reproductive health, newborn screening, birth defects, developmental disabilities, genetic testing, chronic diseases such as cancer and diabetes, environmental and occupational health, laboratory methods, bioinformatics, and statistical methods.
Genomics & Precision Health Database
This database includes published scientific literature on evidence-based translation of genomic and precision health discoveries into improved health care and population health. The database features information on topics that include reproductive health, birth defects, newborn screening, chronic diseases such as cancer and diabetes, pharmacogenomics, and family health history, guidelines and recommendations.
Tier-Classified Guidelines Database
This database contains guidelines from the Genomics and Precision Health Database, sorted according to the highest evidence tier level that could be assigned to recommendations from each guideline. The sorting process is based on our previous method for classifying genomic applications (described in Clinical Pharmacology and Therapeutics, 2014), except that guideline documents rather than clinical scenarios are sorted according to evidence level'
Pathogen Advanced Molecular Detection Database
This database includes published scientific literature, popular press articles, tools, and databases on the emerging role of pathogen genomics and host-pathogen interactions in infectious disease control and prevention. It includes information on methods, evolution and pathogenicity, detection and diagnosis, outbreaks, epidemiology and transmission, antimicrobials, and vaccines and host-pathogen interactions. The database contains items from all previous weekly editions of Advanced Molecular Detection Clips, as well as from the current edition. Clips are selected weekly from a variety of sources, including PubMed, journal tables of contents, and online media.
All of Us Reports and Publications Database
All of Us Reports and Publications Database is an online, continuously updated, searchable database of scientific publications, NIH and CDC resources, and other materials that capture emerging discoveries and applications resulting from the All of Us Research Program with a special focus on genomics, molecular and other precision health applications that may benefit health. Contents include PubMed records via an automated PubMed search algorithm, preprint records, the relevant information from selected websites and media sources selected by experts, and linkages to contents from our curated PHGKB databases.
Human Genome Epidemiology Literature Finder
Human Genome Epidemiology Literature Finder is a search engine for finding published literature on genetic associations and other human genome epidemiology. The search query can include disease/outcome, environmental factors, genes,author's name, affiliation, etc. The results can be further refined by the filtering feature.The list of selected articles can be redirected to the PubMed website to take advantage of the functionalityit provides, such as uploading to reference software.
Epigenetic Epidemiology Publications Database
The Epigenetic Epidemiology Publications Database (EEPD) provides access to a knowledge base that is continuously updated using an automated process based on machine learning. EEPD includes PubMed citations for studies that report associations of epigenetic marks—such as DNA methylation, microRNAs, and histone modifications—with diseases and traits in human populations.
PHGKB Horizon Scan
Genomics Precision Health Scan
Genomics Precision Health Scan features emerging roles of human genomics, testing and interventions in a wide variety of noncommunicable diseases across the life span, including, birth defects, newborn screening, reproductive health, childhood diseases, cancer, chronic diseases, pharmacogenomics, family health history, guidelines and recommendations. The sweep also includes news, reviews, commentaries, tools and databases.
Advanced Molecular Detection Clips
Advanced Molecular Detection(AMD) Clips are selected from a variety of sources, including PubMed, journal tables of contents, and online media. Special emphasis is given to the use of next-generation genetic sequencing in public health surveillance, investigation, and development of new diagnostics and interventions. The collection is not comprehensive but aims to capture highlights, while surveying a wide range of topics. CDC-authored articles are flagged.
Non-Genomics Precision Health Scan
The latest information and publications on the impact of big data science, machine learning and predictive analytics on public health.
New CDC-authored Publications Scan
The latest CDC-authored publications in genomics and precision health.
Specialized Databases
Specialized PHGKBs are the subset databases of the overall PHGKB for specific domains. Currently four specialized PHGKBs are available. We will make more specialized PHGKBs in the future.
- Cancer PHGKB
- Diabetes PHGKB
- HLBS-PopOmics
HLBS-PopOmics is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other materials that address the translation of genomic and other precision health discoveries into improved health care and prevention related to Heart and Vascular Diseases(H), Lung Diseases(L), Blood Diseases(B), and Sleep Disorders(S). HLBS-PopOmics is a specialized database of the overall PHGKB.
- Rare Diseases PHGKB
Rare Disease PHGKB is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other information that address the public health impact and translation of genomic and other precision health discoveries into improved health outcomes related to rare diseases. Rare Diseases PHGKB is a specialized database of the overall PHGKB and was developed with direct links to the NIH Genetics and Rare Disease Information Center. In the United States, a rare disease is defined as a condition that affects fewer than 200,000 people. There may be as many as 7,000 rare diseases. Only a few types of rare diseases are tracked when a person is diagnosed. These include certain infectious diseases, birth defects, and cancers. It also includes the diseases on state newborn screening tests. Browse the full list of A-Z list of rare diseases on the NIH website.
- Infectious Diseases PHGKB
- Health Equity PHGKB
- Family Health History PHGKB
- Reproductive and Child Health PHGKB
- Neurological Disorders PHGKB
- PGx PHGKB
- Primary Immune Deficiency Diseases PHGKB
- Environmental Health PHGKB
- Economic Evaluation PHGKB
- Implementation Science PHGKB
Cancer PHGKB is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other materials that address the translation of genomic and other precision health discoveries into improved health care and prevention related to cancer. Cancer PHGKB is a specialized database of the overall PHGKB.
Diabetes PHGKB is an online, continuously updated, searchable database of published scientificliterature, CDC and NIH resources, and other materials thataddress the translation of genomic and other precision health discoveries into improved health care and prevention related to diabetes. Diabetes PHGKB is a specialized database of the overall PHGKB.
Infectious Diseases Cancer PHGKB is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other materials that address the impact of genomics, advanced molecular detection, and precision health technologies on the control and prevention of infectious diseases. Infectious Diseases PHGKB is a specialized database of the overall PHGKB.
Health Equity PHGKB is an online, continuously updated, searchable database of genomics and precision health information and publications relevant to health equity. Health equity is when everyone has the opportunity to be as healthy as possible. Search terms are derived from a list provided by the Association for Territorial Health Officials which includes terms such as diversity, health disparities, and others. The search algorithm combines terms in health equity with those of genomics and precision health.
Family Health History PHGKB is an online, continuously updated, searchable database of information and publications relevant to the role of family health history in healthcare and disease prevention. Family health history is a record of the diseases and health conditions within a family. Family members share genes, behaviors such as exercise habits, diet and environmental exposures. Family Health History of a disease may be a risk factor for the same and other diseases. Family Health History PHGKB combines all information in PHGB on family health history in one place. It also provide links to important tools and resources.
Reproductive and Child Health PHGKB is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other materials that address the translation of genomic and other precision health discoveries into improved health care and prevention related to reproductive and Child Health, newborn screening, birth defects and developmental disorders. RCH PHGKB is a specialized database of the overall PHGKB.
Neurological Disorders (ND) PHGKB is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other information that address the public health impact and translation of genomic and other precision health discoveries into improved health outcomes related to neurological disorders. ND PHGKB is a specialized database of the overall PHGKB. Browse the A-Z list of neurological disorders on the NIH website
PGx PHGKB is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other materials that address the translation of genomic and other precision health discoveries into improved health care and prevention related to medications. PGx PHGKB is a specialized database of the overall PHGKB.
Primary Immune Deficiency Diseases (PI) PHGKB is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other information that address the public health impact and translation of genomic and other precision health discoveries into improved health outcomes related to primary immune deficiency diseases.
Environmental Health PHGKB is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other materials that address the use of genomic and other precision health technologies in addressing environmental health issues including epidemiology, translation, policies and guidelines and population health programs and impact.
Economic Evaluation PHGKB is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other materials that identify, measure, value, and compare the costs and consequences of genomic and other precision health interventions, policies and programs. Economic Evaluation PHGKB is a specialized database of the overall PHGKB.
Implementation Science PHGKB is an online, continuously updated, searchable database of information and publications relevant to the role of implementation science to accelerate the translation of genomics and precision health applications into practice and programs. The ultimate success of these applications will depend on the incorporation of implementation science tools and methods in research. This research is relevant at the global, national, state, community and health systems level.
Scientific Publications Related to PHGKB
- Wei Yu, Emily Drzymalla, Matheus Fernandes Gyorfy, Muin J. Khoury, Yan V. Sun & Marta Gwinn. Navigating epigenetic epidemiology publications. Epigenetics Communications volume 3, Article number: 8 (2023)
- Wei Yu, Emily Drzymalla, Marta Gwinn and Muin J. Khoury. COVID-19 GPH: tracking the contribution of genomics and precision health to the COVID-19 pandemic response. BMC Infectious Diseases (2022) 22:402.
- Wei Yu, Marta Gwinn, Muin J. Khoury. A New Resource for Genomics and Precision Health Information and Publications on the Investigation and Control of COVID-19 and other Coronaviruses. BIORXIV, April 21, 2020.
- Mensah GA, Yu W, Barfield WL, Clyne M, Engelgau MM, Khoury MJ. HLBS-PopOmics: an online knowledge base to accelerate dissemination and implementation of research advances in population genomics to reduce the burden of heart, lung, blood, and sleep disorders. Genet Med. 2018 Sep 10. doi: 10.1038/s41436-018-0118-1
- Genomics and Health Impact Blog Posted on November 20, 2017 by Wei Yu and Muin J. Khoury Public health genomics information is now easily accessible online
- Yu W, Gwinn M, Dotson WD, Green RF, Clyne M, Wulf A, Bowen S, Kolor K, Khoury MJ. A knowledge base for tracking the impact of genomics on population health Genet Med.2016 Dec;18(12):1312-1314
- Genomics and Health Impact Blog Posted on November 4, 2015 by Muin J. Khoury and Wei Yu, Dealing with the Genomics and Health Information Overload: Introducing the CDC Public Health Genomics Knowledge Base
- Clyne M, Schully SD, Dotson WD, Douglas MP, Gwinn M, Kolor K, Wulf A, Bowen MS, Khoury MJ. Horizon scanning for translational genomic research beyond bench to bedside. Genet Med. 2014 Jan 9.
- Dotson WD, Douglas MP, Kolor K, Stewart AC, Bowen MS, Gwinn M, Wulf A, Anders HM, Chang CQ, Clyne M, Lam TK, Schully SD, Marrone M, Feero WG, Khoury MJ. Prioritizing genomic applications for action by level of evidence: a horizon-scanning method. Clin Pharmacol Ther. 2014 Apr;95(4):394-402.
- Yu W, Yesupriya A, Wulf A, Hindorff LA, Dowling N, Khoury MJ, Gwinn M. GWAS Integrator: a bioinformatics tool to explore human genetic associations reported in published genome-wide association studies. Eur J Hum Genet. 2011 Oct;19(10):1095-9.
- Yu W, Clyne M, Khoury MJ, Gwinn M. Phenopedia and Genopedia: Disease-centered and Gene-centered Views of the Evolving Knowledge of Human Genetic Associations. Bioinformatics. 2010 Jan 1;26(1):145-6. Epub 2009 Oct 27.
- Yu W, Ned R, Wulf A, Liu T, Khoury MJ, Gwinn M. The need for genetic variant naming standards in published abstracts of human genetic association studies. BMC Res Notes. 2009 Apr 14; 2:56.
- Yu W, Clyne M, Dolan SM, Yesupriya A, Wulf A, Liu T, Khoury MJ, Gwinn M. GAPscreener: an automatic tool for screening human genetic association literature in PubMed using the support vector machine technique. BMC Bioinformatics. 2008 Apr 22;9:205.
- Yu W, Gwinn M, Clyne M, Yesupriya A, Khoury MJ. A navigator for human genome epidemiology. Nat Genet. 2008 Feb;40(2):124-5.
- Yu W, Wulf A, Liu T, Khoury MJ, Gwinn M. Gene Prospector: an evidence gateway for evaluating potential susceptibility genes and interacting risk factors for human diseases. BMC Bioinformatics. 2008 Dec 8; 9:528.
- Yu W, Yesupriya A, Wulf A, Qu J, Gwinn M, Khoury MJ. An automatic method to generate domain-specific investigator networks using PubMed abstracts. BMC Med Inform Decis Mak 2007 Jun 20;7(1):17.
- Yu W, Yesupriya A, Wulf A, Qu J, Khoury MJ, Gwinn M. An open source infrastructure for managing knowledge and finding potential collaborators in a domain-specific subset of PubMed, with an example from human genome epidemiology. BMC Bioinformatics. 2007 Nov 9;8:436.
- Page last reviewed:Feb 1, 2024
- Page last updated:Apr 25, 2024
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