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Environmental Health PHGKB

Specific PHGKB|Environmental Health PHGKB|PHGKB

Last Posted: Sep 26, 2022
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Somatic loss of the Y chromosome is associated with arsenic exposure among Bangladeshi men.
Demanelis Kathryn et al. International journal of epidemiology 2022 9

Ten percent of genotyped men had LoY in at least 5% of cells and % LoY increased with age. Among men randomly selected for genotyping (n?=?778), higher arsenic in drinking water, arsenic consumed and urinary arsenic were associated with increased % LoY (P?=?0.006, P?=?0.06 and P?=?0.13, respectively). LoY was associated with increased risk of incident skin lesions (P?=?0.008).

Genes influence complex traits through environments that vary between geographic regions
Nature Genetics, September 6, 2022

Migration can increase regional differences in both DNA variants and environmental factors that are associated with socio-economic status. Without controlling for geography, associations between genes and complex traits will therefore include effects of environmental differences between high-income and low-income regions.

From the Genome to the Exposome: Mapping Causal Associations Between Environmental Factors and Population Health
D Rasooly et al, CDC Blog Post, September 6, 2022

Complementary to the “genome,” which is the complete set of an individual’s genetic information, the “exposome” represents an individual’s complete set of environmental exposures throughout their lifetime. Coined in 2005, the “exposome” captures the variable and dynamic environmental exposures from the prenatal period onwards. Factors studied in the exposome extend from social differences and inequalities to behavioral factors such as tobacco smoking and physical activity. Our genome and exposome interact throughout our lives in causing various diseases.

Environmental Justice Index
ATSDR, August 2022

The Environmental Justice Index uses data from the U.S. Census Bureau, the U.S. Environmental Protection Agency, the U.S. Mine Safety and Health Administration, and the U.S. Centers for Disease Control and Prevention to rank the cumulative impacts of environmental injustice on health for every census tract. Census tracts are subdivisions of counties for which the Census collects statistical data. The EJI ranks each tract on 36 environmental, social, and health factors and groups them into three overarching modules and ten different domains.


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About EH PHGKB

Environmental Health PHGKB is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other materials that address the use of genomic and other precision health technologies in addressing environmental health issues including epidemiology, translation, policies and guidelines and population health programs and impact...more

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Disclaimer: Articles listed in the Public Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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