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Environmental Health PHGKB

Specific PHGKB|Environmental Health PHGKB|PHGKB

Last Posted: Sep 26, 2022
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Somatic loss of the Y chromosome is associated with arsenic exposure among Bangladeshi men.
Demanelis Kathryn et al. International journal of epidemiology 2022 9

Ten percent of genotyped men had LoY in at least 5% of cells and % LoY increased with age. Among men randomly selected for genotyping (n?=?778), higher arsenic in drinking water, arsenic consumed and urinary arsenic were associated with increased % LoY (P?=?0.006, P?=?0.06 and P?=?0.13, respectively). LoY was associated with increased risk of incident skin lesions (P?=?0.008).

Genes influence complex traits through environments that vary between geographic regions
Nature Genetics, September 6, 2022

Migration can increase regional differences in both DNA variants and environmental factors that are associated with socio-economic status. Without controlling for geography, associations between genes and complex traits will therefore include effects of environmental differences between high-income and low-income regions.

From the Genome to the Exposome: Mapping Causal Associations Between Environmental Factors and Population Health
D Rasooly et al, CDC Blog Post, September 6, 2022

Complementary to the “genome,” which is the complete set of an individual’s genetic information, the “exposome” represents an individual’s complete set of environmental exposures throughout their lifetime. Coined in 2005, the “exposome” captures the variable and dynamic environmental exposures from the prenatal period onwards. Factors studied in the exposome extend from social differences and inequalities to behavioral factors such as tobacco smoking and physical activity. Our genome and exposome interact throughout our lives in causing various diseases.

Environmental Justice Index
ATSDR, August 2022

The Environmental Justice Index uses data from the U.S. Census Bureau, the U.S. Environmental Protection Agency, the U.S. Mine Safety and Health Administration, and the U.S. Centers for Disease Control and Prevention to rank the cumulative impacts of environmental injustice on health for every census tract. Census tracts are subdivisions of counties for which the Census collects statistical data. The EJI ranks each tract on 36 environmental, social, and health factors and groups them into three overarching modules and ten different domains.

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