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COVID-19 GPH|Home|PHGKB Last data update: Jan 28, 2023 . (Total: 43201 Documents since 2020)

Last Posted: Jan-28-2023 05:35:03
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Should COVID vaccines be yearly? Proposal divides US scientists
M Kozlov, Nature, January 27, 2023

Scientists are split about a US Food and Drug Administration’s (FDA) proposal to update COVID-19 vaccines once a year, similar to the agency’s approach for annually updating influenza vaccines. At a meeting of the FDA’s vaccine advisory panel on 26 January, some researchers argued that the proposal to offer an updated vaccine every US autumn would help simplify the country’s complex COVID immunization schedule and might boost uptake as a result. But other scientists were less convinced about the timeline — or whether healthy adults should be urged to receive an annual COVID-19 jab at all.

Spike Gene Target Amplification in a Diagnostic Assay as a Marker for Public Health Monitoring of Emerging SARS-CoV-2 Variants — United States, November 2021–January 2023
HM Scobie et al, MMWR, January 25, 2023

When early nowcast estimates of rapidly emerging variants lacked precision and geographic resolution because of lags in genomic sequencing results, SGTF/SGTP estimates were used as complementary data by CDC and the SARS-CoV-2 Interagency Group to support guidance on the use of monoclonal antibody therapies. SGTF/SGTP data were also used as proxy markers in several early studies of vaccine effectiveness and severity of emerging variants (3,5,6). Continued monitoring of SGTF/SGTP patterns will likely serve as a useful complement to genomic surveillance of SARS-CoV-2 lineages.

A Randomized Trial Comparing Omicron-Containing Boosters with the Original Covid-19 Vaccine mRNA-1273
IT Lee et al, MEDRXIV, January 24, 2023

The bivalent omicron BA.1 containing booster elicited superior neutralizing antibody responses against omicron BA.1 with acceptable safety results consistent with the BA.1 monovalent vaccine. Incidence rates for Covid-19 were numerically lower in participants who received mRNA-1273.214 compared to the original booster vaccine mRNA-1273, driven by the BA.2 and BA.4 sublineages.

Wastewater and surface monitoring to detect COVID-19 in elementary school settings: The Safer at School Early Alert project
RKF Miller et al, MEDRXIV, January 25, 2023

In 447 data collection days across the nine sites 89 individuals tested positive for COVID-19, and SARS-CoV-2 was detected in 374 surface samples and 133 wastewater samples. Ninety-three percent of identified cases were associated with an environmental sample (95% CI: 88% - 98%); 67% were associated with a positive wastewater sample (95% CI: 57% - 77%), and 40% were associated with a positive surface sample (95% CI: 29% - 52%). The techniques we utilized allowed for near-complete genomic sequencing of wastewater and surface samples.

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Value of DermaCheckup as a novel dedicated digital health solution for teledermatology.
Ilie Petre C, et al. Medicine international 2023 0 0. (1) 5

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Insights in paediatric virology during the COVID-19 era (Review).
Mammas Ioannis N, et al. Medicine international 2023 0 0. (3) 17

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China public emotion analysis under normalization of COVID-19 epidemic: Using Sina Weibo.
Zhang Fa, et al. Frontiers in psychology 2023 0 0. 1066628

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Digital health interventions and quality of home-based primary care for older adults: A scoping review protocol.
Silva Ísis de Siqueira, et al. Frontiers in public health 2023 0 0. 1022587

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The Usability of Homelab, a Digital Self-service at a Dutch General Practice, for Diagnostic Tests: Pilot Study With a Questionnaire.
Schnoor Kyma, et al. JMIR formative research 2023 0 0. e42151

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A dual graph neural network for drug-drug interactions prediction based on molecular structure and interactions.
Ma Mei, et al. PLoS computational biology 2023 0 0. (1) e1010812

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Big data- and artificial intelligence-based hot-spot analysis of COVID-19: Gauteng, South Africa, as a case study.
Lieberman Benjamin, et al. BMC medical informatics and decision making 2023 0 0. (1) 19

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Entity and relation extraction from clinical case reports of COVID-19: a natural language processing approach.
Raza Shaina, et al. BMC medical informatics and decision making 2023 0 0. (1) 20

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Comparison of two SARS-CoV-2 RT-PCR assays and implication of the instrument software on cycle threshold (Ct) value.
Farfour Eric, et al. Annales de biologie clinique 2023 0 0. (6) 537-540

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Heme Oxygenase-1 (HMOX1) Gene Polymorphisms as Predictive Markers of Increased Risk of Thrombosis among Patients with COVID-19:
Shakir Mohammed Mai, et al. Galen medical journal 2023 0 0. e2398

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About COVID-19 GPH

COVID-19 GPH is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other materials that capture emerging discoveries and applications of genomics, molecular and other precision medicine and precision public health tools in the investigation and control of COVID-19. Contents include PubMed records via an automated pubmed search algorithm, preprint records from NIH iCite, the relevant information from many media sources picked by experts, and linkages to contents from our curated PHGKB databases.

Site Citation:
Wei Yu, et al. COVID-19 GPH: tracking the contribution of genomics and precision health to the COVID-19 pandemic response. BMC Infectious Diseases (2022) 22:402.

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All Records43201
Genomics Precision Health31550
Non-Genomics Precision Health11651

Publication Categories Brand

Variants 12545
Vaccines 10698
Treatment 9953
Mechanism 9854
Diagnosis 7243
Prevention 5189
Surveillance 3795
Forecasting 3363
Transmission 2065
Health Equity 1111

Publication Types

PubMed Records32845
Online News/Reports/Publications431

Genomics Precision Health (GPH): The use of pathogen and human genomics and advanced molecular detection methods in discovery, clinical and public health investigations and response to COVID-19.
Non Genomics Precision Health (non-GPH): The use of big data, data science, digital health, machine learning and predictive analytic methods (not involving genomics) in discovery, clinical and public health investigations and response to COVID-19

Following categories are annotated by LitCovid from NCBI NIH.
MechanismUnderlying cause(s) of covid-19 infections and transmission & possible drug mechanism of action
Transmission Characteristics and modes of covid-19 transmissions, such as human-to-human
DiagnosisDisease assessment through symptoms, test results, and radiological features
PreventionPrevention, control, response and management strategies
Case ReportDescriptions of specific patient cases
ForecastingModelling and estimating the trend of covid-19 spread

Following categories are annotated by the text mining tool from CDC PHGKB
Health EquityRelevant to health equity. Search terms are derived from a list provided by the Association for Territorial Health Officials which include terms such as diversity, health disparities, and others.
VaccineRelevant to vaccine development, evaluation, implementation and impact. For additional information on vaccines and COVID-19. Check out general CDC Information pages
VariantRelevant to SARS-CoV-2 variants and their impact on public health. For additional information on variants COVID-19. Check out CDC New Variants of the Virus that Causes COVID-19 page
SurveillanceRelevant to SARS-CoV-2 public health surveillance and tracking. For additional information on COVID-19 surveillance, check out CDC COVID-19 Data Tracker

Disclaimer: Articles listed in the Public Health Genomics and Precision Health Knowledge Base are selected by the CDC Office of Genomics and Precision Public Health to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.