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COVID-10 GPH

COVID-19 GPH|Home|PHGKB Last data update: Apr 11, 2021 . (Total: 21915 Documents since 2020)
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Last Posted: Apr-11-2021 13:14:02
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Early evidence of COVID-19 vaccine effectiveness within the general population of California
K Andrekjo et al, MEDRXIV, April 10, 2021

Among 325 cases, 23 (7%) and 13 (4%) received BNT162b2 and mRNA-1273, respectively; 8 (2%) were fully vaccinated with either product. Among 260 controls, 49 (19%) and 49 (19%) received BNT162b2 and mRNA-1273, respectively; 42 (16%) were fully vaccinated with either product. Among fully vaccinated individuals, vaccine effectiveness was 86%. Vaccine effectiveness was 66% and 78% one week following a first and second dose, respectively.

Evidence for increased breakthrough rates of SARS-CoV-2 variants of concern in BNT162b2 mRNA vaccinated individuals
T Kustin et al, MEDRXIV, April 9, 2021

We performed a case-control study that examined whether BNT162b2 vaccinees with documented SARS-CoV-2 infection were more likely to become infected with B.1.1.7 or B.1.351 compared with unvaccinated individuals. Vaccinees infected at least a week after the second dose were disproportionally infected with B.1.351 (odds ratio of 8:1). Those infected between two weeks after the first dose and one week after the second dose, were disproportionally infected by B.1.1.7 (odds ratio of 26:10), suggesting reduced vaccine effectiveness against both VOCs under different dosage/timing conditions.

A National Open Genomics Consortium for the COVID-19 Response
CDC, April 9, 2021

The Advanced Molecular Detection (program established the SARS-CoV-2 Sequencing for Public Health Emergency Response, Epidemiology and Surveillance (SPHERES) to coordinate SARS-CoV-2 sequencing. The SPHERES collaboration includes scientists from clinical and public health laboratories, academic institutions, and the private sector. SPHERES will strengthen COVID-19 mitigation strategies.

Neutralization of SARS-CoV-2 variants by convalescent and vaccinated serum
TA Bates et al, MEDRXIV, April 9, 2021

We tested human sera from large, demographically balanced cohorts of BNT162b2 vaccine recipients (n=51) and COVID-19 patients (n=44) for neutralizing antibodies against SARS-CoV-2 variants B.1.1.7 and B.1.351. Although the effect is more pronounced in the vaccine cohort, both B.1.1.7 and B.1.351 show significantly reduced levels of neutralization by vaccinated and convalescent sera. Age is negatively correlated with neutralization in vaccine.


news Latest News and Publications
The emergence, surge and subsequent wave of the SARS-CoV-2 pandemic in New York metropolitan area: The view from a major region-wide urgent care provider.
M Rane et al, MEDRXIV, April 20, 2021

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Direct and indirect effectiveness of mRNA vaccination against SARS-CoV-2 infection in long-term care facilities in Spain
S Monge et al, MEDRXIV, April 10, 2021

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Rise of Variants in Europe Shows How Dangerous the Virus Can Be
J Holder et al, NY Times, April 9, 2021

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Multilevel Deep-Aggregated Boosted Network to Recognize COVID-19 Infection from Large-Scale Heterogeneous Radiographic Data.
Owais Muhammad, et al. IEEE journal of biomedical and health informatics 2021 4 0.

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Classification and analysis of outcome predictors in non-critically ill COVID-19 patients.
Venturini Sergio, et al. Internal medicine journal 2021 4 0.

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SARS-CoV-2 infection dynamics in Denmark, February through October 2020: Nature of the past epidemic and how it may develop in the future.
Rasmussen Steen, et al. PloS one 2021 0 0. (4) e0249733

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REDASA: A Secure Continually Updating Web-Source Processing Pipeline supporting a REaltime DAta Synthesis and Analysis of Scientific Literature.
Vaghela Uddhav, et al. Journal of medical Internet research 2021 4 0.

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A deep learning algorithm to detect coronavirus (COVID-19) disease using CT images.
Mohammadpoor Mojtaba, et al. PeerJ. Computer science 2021 0 0. e345

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Preparing Workplaces for Digital Transformation: An Integrative Review and Framework of Multi-Level Factors.
Trenerry Brigid, et al. Frontiers in psychology 2021 0 0. 620766

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COVID-19 in Portugal: predictability of hospitalization, ICU and respiratory-assistance needs.
Patrício André, et al. Journal of medical Internet research 2021 3 0.

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About COVID-19 GPH

COVID-19 GPH is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other materials that captures emerging discoveries and applications of genomics, molecular and other precision medicine and precision public health tools in the investigation and control of COVID-19. Contents include PubMed records via an automated pubmed search algorithm, preprint records from NIH iCite, the relevant information from many media sources picked by experts, and linkages to contents from our curated PHGKB databases.


Genomics Precision Health (GPH): The use of pathogen and human genomics and advanced molecular detection methods in discovery, clinical and public health investigations involving COVID-19.
Non Genomics Precision Health (non-GPH): The use of big data, data science and machine learning methods (not involving genomics) in discovery, clinical and public health investigations involving COVID-19


Following categories are annotated by LitCovid from NCBI NIH.
MechanismUnderlying cause(s) of covid-19 infections and transmission & possible drug mechanism of action
Transmission Characteristics and modes of covid-19 transmissions, such as human-to-human
DiagnosisDisease assessment through symptoms, test results, and radiological features
PreventionPrevention, control, response and management strategies
Case ReportDescriptions of specific patient cases
ForecastingModelling and estimating the trend of covid-19 spread

Following categories are annotated by the text mining tool from CDC PHGKB
Health EquityRelevant to health equity. Search terms are derived from a list provided by the Association for Territorial Health Officials which include terms such as diversity, health disparities, and others.
VaccineRelevant to vaccine development, evaluation, implementation and impact. For additional information on vaccines and COVID-19. Check out general CDC Information pages
VariantRelevant to SARS-CoV-2 variants and their impact on public health. For additional information on variants COVID-19. Check out CDC New Variants of the Virus that Causes COVID-19 page
SurveillanceRelevant to SARS-CoV-2 public health surveillance and tracking. For additional information on COVID-19 surveillance, check out CDC COVID-19 Data Tracker

Disclaimer: Articles listed in the Public Health Genomics and Precision Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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