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COVID-19 GPH|Home|PHGKB Last data update: Jul 31, 2021 . (Total: 23467 Documents since 2020)

Last Posted: Jul-31-2021 09:05:23
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The overlooked superpower of mRNA vaccines
M Hackman, Science, July 28, 2021

"All COVID-19 vaccines are not created equal,” says Eric Topol, a physician-scientist at the Scripps Research Translational Institute. “It’s clear that the two mRNA vaccines are highly effective at preventing infection—and that others wouldn’t be expected to break the chain as well.” The large clinical trials that persuaded governments around the world to authorize COVID-19 vaccines mostly looked at their ability to block symptomatic disease and illness severe enough to lead to hospitalization or death.

COVID-19 Vaccine Safety in Adolescents Aged 12–17 Years — United States, December 14, 2020–July 16, 2021
AM Hause et al, MMWR, July 30, 2021

In preauthorization trials of the Pfizer-BioNTech COVID-19 vaccine, adolescents aged 12–17 years reported local and systemic mild and moderate reactions. Myocarditis has been observed after vaccination with mRNA vaccines in postauthorization monitoring. Local and systemic reactions after vaccination with Pfizer-BioNTech vaccine were commonly reported by adolescents aged 12–17 years to U.S. vaccine safety monitoring systems, especially after dose 2. A small proportion of these reactions are consistent with myocarditis.

Can Vaccine Prioritization Reduce Disparities in Covid-19 Burden for Historically Marginalized Populations?
E Rosenstrom et al, MEDRXIV, July 30, 2021

We use an agent-based simulation model of North Carolina to project SARS-CoV-2 infections and COVID-19-associated deaths, hospitalizations, and cases over 18 months (7/1/2020-12/31/2021) with vaccine distribution beginning 12/13/2020 to frontline medical and people 75+, assuming initial uptake similar to influenza vaccine. We show that prioritization strategies have differential impact on mortality, morbidity, and disparities overall and by race and ethnicity. If prioritization schemes were not paired with increased uptake in HMPs, disparities did not improve and could worsen.

Outbreak of SARS-CoV-2 Infections, Including COVID-19 Vaccine Breakthrough Infections, Associated with Large Public Gatherings — Barnstable County, Massachusetts, July 2021
CM Brown et al, MMWR, July 30,2021

In July 2021, following multiple large public events in a Barnstable County, Massachusetts, town, 469 COVID-19 cases were identified among Massachusetts residents who had traveled to the town during July 3–17; 346 (74%) occurred in fully vaccinated persons. Testing identified the Delta variant in 90% of specimens from 133 patients. Cycle threshold values were similar among specimens from patients who were fully vaccinated and those who were not.

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Genomic epidemiology of SARS-CoV-2 divulge B.1, B.1.36, and B.1.1.7 as the most dominant lineages in first, second, and third wave of SARS-CoV-2 infections in Pakistan
A Basheer et al, MEDRXIV, July 30, 2021

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Correlates of Neutralizing/SARS-CoV-2-S1-binding Antibody Response with Adverse Effects and Immune Kinetics in BNT162b2-Vaccinated Individuals
K Maeda et al, MEDRXIV, July 30, 2021

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Diagnostic performance of a novel digital immunoassay (RapidTesta SARS-CoV-2): a prospective observational study with 1,127 nasopharyngeal samples
H Suzuki et al, MEDRXIV, July 30, 2021

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SARS-CoV-2 introduction and lineage dynamics across three epidemic peaks in Southern Brazil: massive spread of P.1
APM Varela et al, MEDRXIV, July 30, 2021

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3D CNN classification model for accurate diagnosis of coronavirus disease 2019 using computed tomography images.
Li Yifan, et al. Journal of medical imaging (Bellingham, Wash.) 2021 0 0. (Suppl 1) 017502

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Optimizing Healthcare Through Digital Health and Wellness Solutions to Meet the Needs of Patients With Chronic Disease During the COVID-19 Era.
Seixas Azizi A, et al. Frontiers in public health 2021 0 0. 667654

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Combining a convolutional neural network with autoencoders to predict the survival chance of COVID-19 patients.
Khozeimeh Fahime, et al. Scientific reports 2021 0 0. (1) 15343

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An ensemble learning approach to digital corona virus preliminary screening from cough sounds.
Mohammed Emad A, et al. Scientific reports 2021 0 0. (1) 15404

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Onset of effects of non-pharmaceutical interventions on COVID-19 infection rates in 176 countries.
Nader Ingo W, et al. BMC public health 2021 0 0. (1) 1472

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CD8+ T-Cell Responses in COVID-19 Convalescent Individuals Target Conserved Epitopes From Multiple Prominent SARS-CoV-2 Circulating Variants.
Redd Andrew D, et al. Open forum infectious diseases 2021 0 0. (7) ofab143

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About COVID-19 GPH

COVID-19 GPH is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other materials that captures emerging discoveries and applications of genomics, molecular and other precision medicine and precision public health tools in the investigation and control of COVID-19. Contents include PubMed records via an automated pubmed search algorithm, preprint records from NIH iCite, the relevant information from many media sources picked by experts, and linkages to contents from our curated PHGKB databases.
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All Records23467
Genomics Precision Health16739
Non-Genomics Precision Health6728

Publication Categories Brand

Mechanism 4349
Treatment 3954
Vaccine 3867
Variant 3381
Diagnosis 2835
Prevention 2821
Forecasting 1889
Surveillance 1728
Transmission 931
Health Equity 615
Case Report 460

Publication Types

PubMed Records17084
Online News/Reports/Publications426

Genomics Precision Health (GPH): The use of pathogen and human genomics and advanced molecular detection methods in discovery, clinical and public health investigations and response to COVID-19.
Non Genomics Precision Health (non-GPH): The use of big data, data science, digital health, machine learning and predictive analytic methods (not involving genomics) in discovery, clinical and public health investigations and response to COVID-19

Following categories are annotated by LitCovid from NCBI NIH.
MechanismUnderlying cause(s) of covid-19 infections and transmission & possible drug mechanism of action
Transmission Characteristics and modes of covid-19 transmissions, such as human-to-human
DiagnosisDisease assessment through symptoms, test results, and radiological features
PreventionPrevention, control, response and management strategies
Case ReportDescriptions of specific patient cases
ForecastingModelling and estimating the trend of covid-19 spread

Following categories are annotated by the text mining tool from CDC PHGKB
Health EquityRelevant to health equity. Search terms are derived from a list provided by the Association for Territorial Health Officials which include terms such as diversity, health disparities, and others.
VaccineRelevant to vaccine development, evaluation, implementation and impact. For additional information on vaccines and COVID-19. Check out general CDC Information pages
VariantRelevant to SARS-CoV-2 variants and their impact on public health. For additional information on variants COVID-19. Check out CDC New Variants of the Virus that Causes COVID-19 page
SurveillanceRelevant to SARS-CoV-2 public health surveillance and tracking. For additional information on COVID-19 surveillance, check out CDC COVID-19 Data Tracker

Disclaimer: Articles listed in the Public Health Genomics and Precision Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.