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Specific PHGKB|Pharmacogenomics PHGKB|PHGKB

Last Posted: Sep 22, 2022
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Building Capacity for Implementation Science in Precision Health and Society: Development of a Course for Professional and Graduate Students in Pharmacy
MC Roberts, J Personalized Medicine, September 14, 2022

Training in the field of implementation science is critical for future pharmacists and pharmaceutical scientists to successfully implement precision health interventions in pharmacy practice. We developed an elective course for second- and third-year students at the UNC Eshelman School of Pharmacy to develop foundational knowledge in implementation science with a focus on precision health implementation. The eight-week course used a flipped classroom format featuring lecture videos, suggested readings, quizzes, guest lectures from experts, case studies, and a group project.

The genetic landscape of major drug metabolizing cytochrome P450 genes—an updated analysis of population-scale sequencing data
Y Zhou et al, The PGX journal, September 6, 2022

Genes encoding cytochrome P450 enzymes (CYPs) are extremely polymorphic and multiple CYP variants constitute clinically relevant biomarkers for the guidance of drug selection and dosing. We previously reported the distribution of the most relevant CYP alleles using population-scale sequencing data. Here, we update these findings by making use of the increasing wealth of data, incorporating whole exome and whole genome sequencing data from 141,614 unrelated individuals across 12 human populations.

Dutch pharmacogenetics working group guideline for the gene-drug interaction of ABCG2, HLA-B and Allopurinol, and MTHFR, folic acid and methotrexate
KH van der Pol et al, EJHG, September 2, 2022

This guideline describes the gene-drug interaction of ABCG2 with allopurinol, HLA-B with allopurinol, MTHFR with folic acid, and MTHFR with methotrexate, relevant for the treatment of gout, cancer, and rheumatoid arthritis. A systematic review was performed based on which pharmacotherapeutic recommendations were developed.

A Systematic Review of Polygenic Models for Predicting Drug Outcomes
A Siemens et al, J Per Med, August 29, 2022

The search uncovered 89 papers that incorporated pharmacogenetic variants in the development of polygenic models. It was found that the most common polygenic models were constructed for drug dosing predictions in anticoagulant therapies (n = 27). While nearly all studies found a significant association with their polygenic model and the investigated drug outcome (93.3%), less than half (47.2%) compared the performance of the polygenic model against clinical predictors, and even fewer (40.4%) sought to validate model predictions in an independent cohort.

news Latest News and Publications
Pharmacogenomic Testing and Depressive Symptom Remission: A Systematic Review and Meta-Analysis of Prospective, Controlled Clinical Trials. External Web Site Icon
Brown Lisa C et al. Clinical pharmacology and therapeutics 2022
Characterizing pharmacogenetic programs using the consolidated framework for implementation research: A structured scoping review. External Web Site Icon
McDermott John H et al. Frontiers in medicine 2022 9945352
Evaluation of race and ethnicity disparities in outcome studies of CYP2C19 genotype-guided antiplatelet therapy. External Web Site Icon
Nguyen Anh B et al. Frontiers in cardiovascular medicine 2022 9991646
Pharmacogenomics in Children. External Web Site Icon
Rieder Michael J et al. Methods in molecular biology (Clifton, N.J.) 2022 2547569-593
Characterization of POR haplotype distribution in African populations and comparison with other global populations. External Web Site Icon
Booyse Ross P et al. Pharmacogenomics 2022
Dutch pharmacogenetics working group guideline for the gene-drug interaction of ABCG2, HLA-B and Allopurinol, and MTHFR, folic acid and methotrexate. External Web Site Icon
van der Pol Karel H et al. European journal of human genetics : EJHG 2022
Pharmacogenomic biomarkers as source of evidence of the effectiveness and safety of antidepressant therapy. External Web Site Icon
Correia Catarina et al. BMC psychiatry 2022 22(1) 576
Pharmacotherapy for children with elevated levels of lipoprotein(a): future directions. External Web Site Icon
de Boer Lotte M et al. Expert opinion on pharmacotherapy 2022
Prevalence and impact of misdiagnosed drug allergy labels among patients with hereditary angioedema. External Web Site Icon
Wong Jane Chi Yan et al. Frontiers in allergy 2022 3953117
A Mixed-Methods Protocol to Identify Best Practices for Implementing Pharmacogenetic Testing in Clinical Settings. External Web Site Icon
Sperber Nina R et al. Journal of personalized medicine 2022 12(8)


Disclaimer: Articles listed in the Public Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.