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PGxPHGKB

Specific PHGKB|Pharmacogenomics PHGKB|Public Health Genomics and Precision Health Knowledge Base (PHGKB)
Effective August 1, 2024, this database was discontinued. All content will remain searchable and be preserved online for historical purposes only until 2029.

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The Path to Genomic Screening—Far From Simple, but the Journey Has Begun

From the article: "Today’s genomic technology introduces a multitude of assays that could be deployed in health care: diagnostic testing of patients with suspected monogenic conditions, polygenic risk prediction for common diseases, pharmacogenomic analysis for drug-gene interactions, analysis of tumors for targetable somatic sequence variations, and noninvasive screening for prenatal chromosomal disorders or occult cancer. Alongside these approaches we must also grapple with screening of the ostensibly healthy population for monogenic diseases of newborns, children, and adults with either targeted or genome-scale sequencing. "

Exceptional Genetics, Generalizable Therapeutics, and Coronary Artery Disease

From the article: "The increasingly widespread availability of genomic sequencing has enabled the identification of persons and families with uniquely favorable traits, including a very low incidence of clinical events. Such exceptional persons across diverse communities are playing an important role in the genesis of medicines for common cardiovascular diseases. "

Pharmacogenomics, Race, and Treatment Outcome in Pediatric Acute Myeloid Leukemia

From the abstract: " Can tailoring the intensity of induction therapy mitigate racial disparities in the outcome of pediatric patients with acute myeloid leukemia (AML)? Findings: In this comparative effectiveness analysis of 86 Black and 359 White patients with AML, Black patients exhibited a higher prevalence of low cytarabine pharmacogenomic 10–single-nucleotide variant (ACS10) scores, which were associated with an unfavorable outcome after initial treatment with low-dose cytarabine-based induction therapy. Augmentation of induction therapy was associated with improved outcome for patients with low ACS10 scores and with no disparity in outcome between Black patients and White patients."

Healthcare utilization and behavior changes following workplace genetic testing at a large U.S. healthcare system

From the abstract: " This study explored employee health behavior changes and healthcare utilization following workplace genetic testing (wGT). Wellness program-associated wGT seeks to improve employee health, but related health implications are unknown. Methods: Employees of a large U.S. healthcare system offering wGT (cancer, heart disease, and pharmacogenomics - PGx) were sent electronic surveys. Self-reported data from those who received test results were analyzed. Descriptive statistics characterized responses, while logistic regression analyses explored correlates of responses to wGT."


news Latest News and Publications
Primary care research on hypertension: A bibliometric analysis using machine-learning. External Web Site Icon
Yasli Gökben, et al. Medicine 2025 0 0. (47) e40482
High-dimensional mediation analysis to elucidate the role of metabolites in the association between PFAS exposure and reduced SARS-CoV-2 IgG in pregnancy. External Web Site Icon
Guan Haibin, et al. bioRxiv : the preprint server for biology 2025 0 0.
Data mining of adverse drug event signals with Nirmatrelvir/Ritonavir from FAERS. External Web Site Icon
Sun Ji, et al. PloS one 2024 0 0. (12) e0316573
Safety of baricitinib in vaccinated patients with severe and critical COVID-19 sub study of the randomised Bari-SolidAct trial. External Web Site Icon
Viermyr Hans-Kittil, et al. EBioMedicine 2024 0 0. 105511
Interactions of warfarin with COVID-19 vaccine/drugs, monoclonal antibodies, and targeted anticancer agents from real-world data mining. External Web Site Icon
Gao Yan, et al. Frontiers in pharmacology 2024 0 0. 1418997
Population Pharmacokinetics and Dosing Regimen Analysis of Nirmatrelvir in Chinese Patients with COVID-19 Infection. External Web Site Icon
Zhang Runcong, et al. Drug design, development and therapy 2024 0 0. 5517-5527
Application of machine learning for delirium prediction and analysis of associated factors in hospitalized COVID-19 patients: A comparative study using the Korean Multidisciplinary cohort for delirium prevention (KoMCoDe). External Web Site Icon
Park Hye Yoon, et al. International journal of medical informatics 2024 0 0. 105747
Development of a metabolome-based respiratory infection prognostic during COVID-19 arrival. External Web Site Icon
Robinson John I, et al. mBio 2024 0 0. e0334323
Identifying Topics Around Nicotine Gum: A Machine Learning Approach with Twitter Data. External Web Site Icon
Han Eileen, et al. Substance use & misuse 2024 0 0. 1-6
Public Health Benefits of Applying Evidence-Based Best Practices in Managing Patients Hospitalized for COVID-19. External Web Site Icon
Kalil Andre C, et al. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2024 0 0.

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About PGx PHGKB

PGx PHGKB is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other materials that address the translation of genomic and other precision health discoveries into improved health care and prevention related to medications....more

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Disclaimer: Articles listed in the Public Health Knowledge Base are selected by Public Health Genomics Branch to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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