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Cancer PHGKB

Specific PHGKB|Cancer|PHGKB
Last Posted: Jun 20, 2021
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Towards personalized treatment of smoking-related lung cancers
G Middleton, Nature, June 18, 2021

An innovative approach to a phase II clinical trial aims to test the effects of multiple targeted treatments simultaneously in participants in the UK National Lung Matrix Trial. The design makes it possible to study small numbers of people with rare mutations in non-small-cell lung tumours.

Deep learning for end-to-end kidney cancer diagnosis on multi-phase abdominal computed tomography
KH Uhm et al, NPJ Precision Oncology, June 18, 2021

While deep learning has been recently applied to the automated diagnosis of renal tumor, classification of a wide range of subtype classes has not been sufficiently studied yet. In this paper, we propose an end-to-end deep learning model for the differential diagnosis of five major histologic subtypes of renal tumors including both benign and malignant tumors on multi-phase CT.

A DNA methylation-based liquid biopsy for triple-negative breast cancer
K Cristal et al, NPJ Precision Oncology, June 16, 2021

Based on a multiplexed targeted sequencing approach, this assay included 53 amplicons from 47 regions. Analysis of a previously characterized cohort of women with metastatic TNBC with limited quantities of plasma (<2?ml) produced an AUC of 0.92 for detection of a tumor with a sensitivity of 76% for a specificity of 100%.

Genetic testing for inherited colorectal cancer and polyposis, 2021 revision: a technical standard of the American College of Medical Genetics and Genomics (ACMG)
R Mao et al, Genetics in Medicine, June 17, 2021

Given the overlapping phenotypes of the cancer syndromes along with the limited sensitivity of using clinical criteria alone, a multigene panel testing approach to diagnose these conditions using next-generation sequencing (NGS) is effective and efficient.


news Latest News and Publications
Homing in on genomic instability as a therapeutic target in cancer External Web Site Icon
CM BIelski et al, Nat Comms, June 16, 2021
Pan-cancer analysis of SETD2 mutation and its association with the efficacy of immunotherapy External Web Site Icon
M Lu, NPJ Precision Oncology, June 14, 2021
Clinical utility of testing for PALB2 and CHEK2 c.1100delC in breast and ovarian cancer. External Web Site Icon
Woodward Emma R et al. Genetics in medicine : official journal of the American College of Medical Genetics 2021
Clinicopathological Features of BRCA1/2 Mutation-Positive Breast Cancer. External Web Site Icon
Paik Hyun-June et al. Oncology 2021 1-8
Combination chemotherapy versus temozolomide for patients with methylated MGMT (m-MGMT) glioblastoma: results of computational biological modeling to predict the magnitude of treatment benefit. External Web Site Icon
Castro Michael et al. Journal of neuro-oncology 2021
Community research collaboration to develop a promotores-based hereditary breast cancer education program for Spanish-speaking Latinas. External Web Site Icon
Almeida Rebeca et al. Health education research 2021
Crizotinib Versus Conventional Chemotherapy in First-Line Treatment for ALK-Positive Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis. External Web Site Icon
Cruz Barbara D et al. Oncology and therapy 2021
Decoding human cancer with whole genome sequencing: a review of PCAWG Project studies published in February 2020. External Web Site Icon
Giunta Simona et al. Cancer metastasis reviews 2021
Developing a clinical-pathologic model to predict genomic risk of recurrence in patients with hormone receptor positive, human epidermal growth factor receptor-2 negative, node negative breast cancer. External Web Site Icon
Batra Atul et al. Cancer treatment and research communications 2021 28100401
Electronic Family History Screening Tool for Detection of Inherited Cancer Risk: A Prospective Pilot Study. External Web Site Icon
Le Amy et al. American journal of medical quality : the official journal of the American College of Medical Quality 2021

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Disclaimer: Articles listed in the Public Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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