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Cancer PHGKB

Specific PHGKB|Cancer|PHGKB
Last Posted: Mar 05, 2021
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Value of a 21-gene expression assay on core biopsy to predict neoadjuvant chemotherapy response in breast cancer: systematic review and meta-analysis.
Boland M R et al. The British journal of surgery 2021 108(1) 24-31

This systematic review aimed to determine whether the 21-gene expression assay performed on core biopsy at diagnosis predicted pathological complete response (pCR) to neoadjuvant chemotherapy. The study was performed according to PRISMA guidelines. Relevant databases were searched to identify studies assessing the value of the 21-gene expression assay recurrence score in predicting response to neoadjuvant chemotherapy in patients with breast cancer.

BRAF-mutant ctDNA predicts outcomes.
Sidaway Peter et al. Nature reviews. Clinical oncology 2021 3

Circulating tumor DNA (ctDNA) has the potential to improve patient management in a range of disease settings; however, data from large cohorts of patients are currently limited. Now, an analysis of samples from two clinical trials provides further evidence that BRAF mutations present in ctDNA can be used to predict clinical outcome.

A Proclamation on National Colorectal Cancer Awareness Month, 2021
The White House, March 1, 2021

People with increased risk for developing the disease include certain racial and ethnic minority populations, as well as individuals with inflammatory bowel disease, a family history of colorectal cancer, or other risk factors such as tobacco use.

Gene Sequencing for Pathogenic Variants Among Adults With Breast and Ovarian Cancer in the Caribbean
SHL George et al, JAMA Network Open, March 1, 2021

This genetic association study included 1018 adult women and men with breast and ovarian cancer, of which 144 individuals had a pathogenic variant in a moderate- to high-risk gene. This finding was consistent with high rates of premenopausal breast cancer in Black women with Caribbean ancestry.


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Disclaimer: Articles listed in the Public Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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