Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content


Hot Topics of the Day|PHGKB
Search PHGKB:

10/16/2019

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

Sign up MyPHGKB to receive the daily hot topic email alert.

Search Archive:
Archived Hot Topics of the Day By Date

Population BRCA sequencing; time to move to the next phase?
Gourley Charlie et al. BJOG : an international journal of obstetrics and gynaecology 2019 Oct

Precision medicine in pancreatic cancer: treating every patient as an exception.
Herbst Brian et al. The lancet. Gastroenterology & hepatology 2019 Oct (10) 805-810

Patients with pancreatic cancer have not benefited from recent improvements in overall survival brought about by precision medicine in other malignancies. This failure is not due to a dearth of precision-medicine research in pancreatic ductal adenocarcinoma (PDAC), the main type of pancreatic cancer.

The future of cystic fibrosis care: a global perspective.
Bell Scott C et al. The Lancet. Respiratory medicine 2019 Sep

The Lancet Respiratory Medicine Commission on the future of cystic fibrosis care was established at a time of great change in the clinical care of people with the disease, with a growing population of adult patients, widespread genetic testing supporting the diagnosis of cystic fibrosis, and the development of therapies.

HIV & AIDS with DNA HIV

Illuminating HIV outbreaks with AMD
CDC, October 2019 Brand

CDC and health departments use molecular analysis to identify transmission clusters that might not be recognized with traditional public health tools and to better understand hotspots of transmission. The process uses HIV genetic sequences that are generated as part of routine clinical care and shared with health departments.

The PedBE clock accurately estimates DNA methylation age in pediatric buccal cells.
McEwen Lisa M et al. Proceedings of the National Academy of Sciences of the United States of America 2019 Oct

The Polygenic Score (PGS) Catalog
Open Source database, 2019

An open database of polygenic scores and the relevant metadata needed to apply and evaluate them correctly. The catalog currently contains 34 PGS for 12 traits, and encompasses data from 21 publications.I n the current PGS Catalog you can find the scores and metadata.

Gut microbes affect harmful compound in red meat
NIH, October 2019 Brand

Researchers identified an enzyme in gut bacteria that releases an inflammation-causing carbohydrate from meat. Preventing this carbohydrate from entering the body’s tissues could potentially reduce the risk of diseases associated with eating red meat.

African American children may need different asthma treatments
NIH, October 2019 Brand

About half of African American children with poorly controlled asthma benefited more from higher-dose steroids than adding a bronchodilator to treatment. These findings highlight the importance of enrolling populations of diverse ages and races in clinical trials.

The ALS Registry: Hope for Patients, Resources for Research
CDC,October 2019 Brand

The National ALS Registry helps gather confidential information from those who are living with this disease. It is the only population-based registry in the U.S. that collects information to help scientists learn more about who gets ALS and its causes. Nearly 17,000 people in the U.S. are living with ALS.

Sequencing African Genomes Yields New Data Resource with Broad Applicability
ASHG, October 15, 2019

By collaborating globally in a new, large-scale effort, researchers have made strong progress in sequencing genomes from regions and countries across Africa. These findings will enable more broadly representative and relevant studies ranging from basic through clinical genetics.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
TOP