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Tier-Classified Guidelines Database


Tier Table Database|Home|PHGKB
Last data update: Aug 08, 2019. (Total: 372 Documents since 2012)
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Recent Uploaded Publications

Local Coverage Determination (LCD): Biomarker Testing for Neuroendocrine Tumors/Neoplasms (L37851)
The U.S. Centers for Medicare & Medicaid Services

Organization: The Centers for Medicare & Medicaid Services (CMS)
ACG Clinical Guideline: Hereditary Hemochromatosis.
Kowdley Kris V et al. The American journal of gastroenterology 2019 Jul

Organization: The American College of Gastroenterology (ACG)
Consensus Guidelines on Genetic` Testing for Hereditary Breast Cancer from the American Society of Breast Surgeons.
Manahan Eric R et al. Annals of surgical oncology 2019 Jul

Organization: The American Society of Breast Surgeons (ASBrS)
Endoscopic management of polyposis syndromes: European Society of Gastrointestinal Endoscopy (ESGE) guideline.
van Leerdam Monique E et al. Endoscopy 2019 Jul

Organization: The European Society of Gastrointestinal Endoscopy (ESGE)
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen Ezra E W et al. Journal for immunotherapy of cancer 2019 Jul 7(1) 184

Organization: The Society for Immunotherapy of Cancer (SITC)
Somatic gene mutation detection system (P180043)
The U.S. Food & Drug Administration
Organization: The U.S. Food and Drug Administration (FDA)
Prostrate cancer genes nucleic acid amplification test system (P100033)
The U.S. Food & Drug Administration
Organization: The U.S. Food and Drug Administration (FDA)
Cancer predisposition risk assessment system (K182784)
The U.S. Food & Drug Administration
Organization: The U.S. Food and Drug Administration (FDA)
Somatic gene mutation detection system (P190004)
The U.S. Food & Drug Administration
Organization: The U.S. Food and Drug Administration (FDA)
Somatic gene mutation detection system (P190001)
The U.S. Food & Drug Administration
Organization: The U.S. Food and Drug Administration (FDA)
Japan Society of Clinical Oncology provisional clinical opinion for the diagnosis and use of immunotherapy in patients with deficient DNA mismatch repair tumors, cooperated by Japanese Society of Medical Oncology, First Edition.
Mishima Saori et al. International journal of clinical oncology 2019 Jul

Organization: The Japanese Society of Medical Oncology
Draft Recommendation Statement: Abdominal Aortic Aneurysm: Screening,
U.S. Preventive Services, June 2019
Organization: The U.S. Preventive Services Task Force (USPSTF)
Treating HR+/HER2- breast cancer in premenopausal Asian women: Asian Breast Cancer Cooperative Group 2019 Consensus and position on ovarian suppression.
Yeo Winnie et al. Breast cancer research and treatment 2019 Jul

Organization: Expert Panel
International best practice for the evaluation of responsiveness to sapropterin dihydrochloride in patients with phenylketonuria.
Muntau Ania C et al. Molecular genetics and metabolism 2019 127(1) 1-11

Organization: Expert Panel
ESMO-ESGO consensus conference recommendations on ovarian cancer: pathology and molecular biology, early and advanced stages, borderline tumours and recurrent disease.
Colombo N et al. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2019 May

Organization: The European Society for Medical Oncology (ESMO) The European Society of Gynaecologial Oncology (ESGO),
Human herpesvirus 6, 7, and 8 in solid organ transplantation: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.
Pellett Madan Rebecca et al. Clinical transplantation 2019 Mar e13518

Organization: The American Society of Transplantation (AST)
Screening of donor and candidate prior to solid organ transplantation-Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.
Malinis Maricar et al. Clinical transplantation 2019 Mar e13548

Organization: The American Society of Transplantation (AST)
Updated Australian consensus statement on management of inherited bleeding disorders in pregnancy.
Dunkley Scott et al. The Medical journal of Australia 2019 Apr 210(7) 326-332

Organization: The Australian Haemophilia Centre Directors' Organisation (AHCDO)
Lung transplant referral for individuals with cystic fibrosis: Cystic Fibrosis Foundation consensus guidelines.
Ramos Kathleen J et al. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2019 May 18(3) 321-333

Organization: The Cystic Fibrosis Foundation (CFF)
Recommendation for the management of dyslipidemia in Poland - Third Declaration of Sopot. Interdisciplinary Expert Position Statement endorsed by the Polish Cardiac Society Working Group on Cardiovascular Pharmacotherapy.
Szymanski Filip M et al. Cardiology journal 2018 25(6) 655-665

Organization: Expert Panel

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About

This database contains guidelines from the Genomics and Precision Health Database, sorted according to the highest evidence tier level that could be assigned to recommendations from each guideline. The sorting process is based on our previous method for classifying genomic applications (described in Clinical Pharmacology and Therapeutics, 2014), except that guideline documents rather than clinical scenarios are sorted according to evidence level. more

Recent Tier 1 Publications

Somatic gene mutation detection system (P180043)
The U.S. Food & Drug Administration
Prostrate cancer genes nucleic acid amplification test system (P100033)
The U.S. Food & Drug Administration
Cancer predisposition risk assessment system (K182784)
The U.S. Food & Drug Administration
Somatic gene mutation detection system (P190004)
The U.S. Food & Drug Administration
Somatic gene mutation detection system (P190001)
The U.S. Food & Drug Administration

Top 5 Most Viewed

Draft Recommendation Statement and Draft Evidence Review: Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer
The U.S. Preventive Services Task Force

(37 reads)
2019 HRS Expert Consensus Statement on Evaluation, Risk Stratification, and Management of Arrhythmogenic Cardiomyopathy.
Towbin JA, et al. Heart Rhythm. 2019 May 9.

(32 reads)
Use of Biomarkers to Guide Decisions on Adjuvant Systemic Therapy for Women With Early-Stage Invasive Breast Cancer: ASCO Clinical Practice Guideline Update-Integration of Results From TAILORx.
Andre Fabrice et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2019 May JCO1900945

(32 reads)
Meta-analysis and multidisciplinary consensus statement: exome sequencing is a first-tier clinical diagnostic test for individuals with neurodevelopmental disorders.
Srivastava Siddharth et al. Genetics in medicine : official journal of the American College of Medical Genetics 2019 Jun

(32 reads)
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 Genotype and Atomoxetine Therapy.
Brown Jacob T et al. Clinical pharmacology and therapeutics 2019 Feb

(30 reads)

Content Statistics

  • Total Publications: 372
    • Tier 1 Publications: 161
    • Tier 2 Publications: 198
    • Tier 3 Publications: 12
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