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Tier-Classified Guidelines Database


Tier Table Database|Home|PHGKB
Last data update: Jun 13, 2019. (Total: 218 Documents since 2012)
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Recent Uploaded Publications

Recommendations for the implementation of BRCA testing in ovarian cancer patients and their relatives.
Gori S, et al. Crit Rev Oncol Hematol. 2019 May 25;140:67-72

Organization: The AIOM-SIGU-SIBIOC-SIAPEC-IAP Italian Scientific Societies
Meta-analysis and multidisciplinary consensus statement: exome sequencing is a first-tier clinical diagnostic test for individuals with neurodevelopmental disorders.
Srivastava Siddharth et al. Genetics in medicine : official journal of the American College of Medical Genetics 2019 Jun

Organization: Expert Panel
Use of Biomarkers to Guide Decisions on Adjuvant Systemic Therapy for Women With Early-Stage Invasive Breast Cancer: ASCO Clinical Practice Guideline Update-Integration of Results From TAILORx.
Andre Fabrice et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2019 May JCO1900945

Organization: The American Society of Clinical Oncology (ASCO)
2018 Cholesterol Clinical Practice Guidelines: Synopsis of the 2018 American Heart Association/American College of Cardiology/Multisociety Cholesterol Guideline.
Grundy Scott M et al. Annals of internal medicine 2019 May

Organization: The American College of Cardiology (ACC) The American Heart Association (AHA)
2019 HRS Expert Consensus Statement on Evaluation, Risk Stratification, and Management of Arrhythmogenic Cardiomyopathy.
Towbin JA, et al. Heart Rhythm. 2019 May 9.

Organization: The American College of Cardiology (ACC) The Sociedade Brasileira de Arritmias Cardíacas (SOBRAC) The International Society for Heart & Lung Transplantation (ISHLT) The European Heart Rhythm Association (EHRA) The American Society of Echocardiography (ASE) The Asia Pacific Heart Rhythm Society (APHRS) The National Society of Genetic Counselors (NSGC) The Heart Failure Society of America (HFSA) The Latin American Heart Rhythm Society (LAHRS) The American Heart Association (AHA) The Pediatric & Congenital Electrophysiology Society (PACES) The Japanese Heart Rhythm Society (JHRS)
Recommendations for Clinical CYP2C9 Genotyping Allele Selection: A Joint Recommendation of the Association for Molecular Pathology and College of American Pathologists.
Pratt Victoria M et al. The Journal of molecular diagnostics : JMD 2019 May

Organization: The Association for Molecular Pathology (AMP) The College of American Pathologists (CAP)
ESMO recommendations on microsatellite instability testing for immunotherapy in cancer, and its relationship with PD-1/PD-L1 expression and tumour mutational burden: a systematic review-based approach.
Luchini C et al. Annals of oncology : official journal of the European Society for Medical Oncology 2019 May

Organization: The European Society for Medical Oncology
Sequencing as a first-line methodology for cystic fibrosis carrier screening
KA Beauchamp et al, Genetics in Medicine, April 30, 2019
Organization: Expert Panel
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2B6 and Efavirenz-containing Antiretroviral Therapy.
Desta Zeruesenay et al. Clinical pharmacology and therapeutics 2019 Apr

Organization: The Clinical Pharmacogenetics Implementation Consortium (CPIC)
Consensus Statement of the Indian Academy of Pediatrics on Diagnosis and Management of Fragile X Syndrome in India.
Sachdeva Anupam et al. Indian pediatrics 2019 Mar 56(3) 221-228

Organization: Expert Panel
The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome.
Crosbie Emma J et al. Genetics in medicine : official journal of the American College of Medical Genetics 2019 Mar

Organization: The Manchester International Consensus Group
Australasian Gastrointestinal Pathology Society (AGPS) consensus guidelines for universal defective mismatch repair testing in colorectal carcinoma.
Yozu Masato et al. Pathology 2019 Mar

Organization: The Australasian Gastrointestinal Pathology Society (AGPS)
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 Genotype and Atomoxetine Therapy.
Brown Jacob T et al. Clinical pharmacology and therapeutics 2019 Feb

Organization: The Clinical Pharmacogenetics Implementation Consortium (CPIC)
Wilson's Disease: Clinical Practice Guidelines of the Indian National Association for Study of the Liver, the Indian Society of Pediatric Gastroenterology, Hepatology and Nutrition, and the Movement Disorders Society of India.
Nagral Aabha et al. Journal of clinical and experimental hepatology 9(1) 74-98

Organization: The Indian National Association for Study of the Liver The Indian Society of Pediatric Gastroenterology, Hepatology and Nutrition (ISPGHAN) The Movement Disorders Society of India (MDSI)
International clinical guidelines for the management of phosphomannomutase 2-congenital disorders of glycosylation: Diagnosis, treatment and follow up.
Altassan Ruqaiah et al. Journal of inherited metabolic disease 2019 Jan 42(1) 5-28

Organization: Expert Panel
Draft Recommendation Statement and Draft Evidence Review: Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer
The U.S. Preventive Services Task Force
Organization: The U.S. Preventive Services Task Force (USPSTF)
Smoking Cessation Pharmacotherapy Based on Genetically-Informed Biomarkers: What is the Evidence?
Panagiotou Orestis A et al. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2019 Jan

Organization: Expert Panel
Spanish multidisciplinary clinical practice guidelines for Anderson-Fabry Disease in Adults. I. Method and recommendations.
Calderón Sandubete E J et al. Revista clinica espanola 2019 Jan

Organization: Expert Panel
Recommendations for the clinical interpretation of genetic variants and presentation of results to patients with inherited bleeding disorders. A UK Haemophilia Centre Doctors' Organisation Good Practice Paper.
Gomez Keith et al. Haemophilia : the official journal of the World Federation of Hemophilia 2019 Jan 25(1) 116-126

Organization: Expert Panel
An economic model of the cost-utility of pre-emptive genetic testing to support pharmacotherapy in patients with major depression in primary care.
Sluiter Reinier L et al. The pharmacogenomics journal 2019 Jan

Organization: Expert Panel

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Recent Tier 1 Publications

Use of Biomarkers to Guide Decisions on Adjuvant Systemic Therapy for Women With Early-Stage Invasive Breast Cancer: ASCO Clinical Practice Guideline Update-Integration of Results From TAILORx.
Andre Fabrice et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2019 May JCO1900945
Australasian Gastrointestinal Pathology Society (AGPS) consensus guidelines for universal defective mismatch repair testing in colorectal carcinoma.
Yozu Masato et al. Pathology 2019 Mar

Draft Recommendation Statement and Draft Evidence Review: Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer
The U.S. Preventive Services Task Force
Systemic Therapy for Patients With Advanced Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: ASCO Clinical Practice Guideline Update.
Giordano Sharon H et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2018 Jun JCO2018792697
Screening for Osteoporosis to Prevent Fractures: US Preventive Services Task Force Recommendation Statement.
US Preventive Services Task Force, et al. JAMA 2018 Jun 319(24) 2521-2531

Top 5 Most Viewed

Draft Recommendation Statement and Draft Evidence Review: Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer
The U.S. Preventive Services Task Force

(19 reads)
Use of Biomarkers to Guide Decisions on Adjuvant Systemic Therapy for Women With Early-Stage Invasive Breast Cancer: ASCO Clinical Practice Guideline Update-Integration of Results From TAILORx.
Andre Fabrice et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2019 May JCO1900945

(16 reads)
Meta-analysis and multidisciplinary consensus statement: exome sequencing is a first-tier clinical diagnostic test for individuals with neurodevelopmental disorders.
Srivastava Siddharth et al. Genetics in medicine : official journal of the American College of Medical Genetics 2019 Jun

(16 reads)
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 Genotype and Atomoxetine Therapy.
Brown Jacob T et al. Clinical pharmacology and therapeutics 2019 Feb

(15 reads)
2019 HRS Expert Consensus Statement on Evaluation, Risk Stratification, and Management of Arrhythmogenic Cardiomyopathy.
Towbin JA, et al. Heart Rhythm. 2019 May 9.

(14 reads)

About

This database contains guidelines from the Genomics and Precision Health Database, sorted according to the highest evidence tier level that could be assigned to recommendations from each guideline. The sorting process is based on our previous method for classifying genomic applications (described in Clinical Pharmacology and Therapeutics, 2014), except that guideline documents rather than clinical scenarios are sorted according to evidence level. more

Content Statistics

  • Total Publications: 218
    • Tier 1 Publications: 32
    • Tier 2 Publications: 174
    • Tier 3 Publications: 12
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