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Tier-Classified Guidelines Database


Tier Table Database|Home|PHGKB
Last data update: May 17, 2023. (Total: 525 Documents since 2012)
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Recent Uploaded Publications

Indications and management of preimplantation genetic testing for monogenic conditions: a committee opinion.
et al. Fertil Steril 2023
2023 Update on European Atherosclerosis Society Consensus Statement on Homozygous Familial Hypercholesterolaemia: new treatments and clinical guidance.
Marina Cuchel et al. Eur Heart J 2023
2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death.
Katja Zeppenfeld et al. Eur Heart J 2022 43(40) 3997-4126
Consensus clinical management guidelines for acid sphingomyelinase deficiency (Niemann-Pick disease types A, B and A/B).
Tarekegn Geberhiwot et al. Orphanet J Rare Dis 2023 18(1) 85
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants.
Chad A Bousman et al. Clinical pharmacology and therapeutics 2023
2. Classification and Diagnosis of Diabetes: Standards of Care in Diabetes-2023.
Nuha A ElSayed et al. Diabetes care 2022 46(Suppl 1) S19-S40
Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2D6, CYP3A4 and CYP1A2 and antipsychotics.
Lianne Beunk et al. European journal of human genetics : EJHG 2023
Genetic evaluation of living kidney donor candidates: A review and recommendations for best practices.
Christie P Thomas et al. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023
Genetic and metabolic investigations for neurodevelopmental disorders: position statement of the Canadian College of Medical Geneticists (CCMG).
Melissa T Carter et al. Journal of medical genetics 2023
Updated clinical practice recommendations for managing adults with 22q11.2 deletion syndrome.
Erik Boot et al. Genetics in medicine : official journal of the American College of Medical Genetics 2023 100344
Updated clinical practice recommendations for managing children with 22q11.2 deletion syndrome.
Sólveig Óskarsdóttir et al. Genetics in medicine : official journal of the American College of Medical Genetics 2023 100338
Guidelines for the Diagnosis and Treatment of Adult Familial Hypercholesterolemia 2022.
Mariko Harada-Shiba et al. Journal of atherosclerosis and thrombosis 2023
International Consensus Guideline on Small for Gestational Age (SGA): Etiology and Management from Infancy to Early Adulthood.
Hokken-Koelega Anita C S et al. Endocrine reviews 2023
Noninvasive prenatal screening (NIPS) for fetal chromosome abnormalities in a general-risk population: An evidence-based clinical guideline of the American College of Medical Genetics and Genomics (ACMG).
Dungan Jeffrey S et al. Genetics in medicine : official journal of the American College of Medical Genetics 2022
Dutch pharmacogenetics working group (DPWG) guideline for the gene-drug interaction of CYP2D6 and COMT with atomoxetine and methylphenidate.
Nijenhuis Marga et al. European journal of human genetics : EJHG 2022
Dutch pharmacogenetics working group (DPWG) guideline for the gene-drug interaction between UGT1A1 and irinotecan.
Hulshof Emma C et al. European journal of human genetics : EJHG 2022
Genetic testing and counseling for the unexplained epilepsies: An evidence-based practice guideline of the National Society of Genetic Counselors.
Smith Lacey et al. Journal of genetic counseling 2022
Dutch pharmacogenetics working group guideline for the gene-drug interaction of ABCG2, HLA-B and Allopurinol, and MTHFR, folic acid and methotrexate.
van der Pol Karel H et al. European journal of human genetics : EJHG 2022
Mismatch Repair and Microsatellite Instability Testing for Immune Checkpoint Inhibitor Therapy.
Bartley Angela N et al. Archives of pathology & laboratory medicine 2022
Local Coverage Determination (LCD) for Lab-Developed Tests for Inherited Cancer Syndromes in Patients with Cancer
The Centers for Medicare & Medicaid Services (CMS)
Tier: Tier 1

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About

This database contains guidelines from the Genomics and Precision Health Database, sorted according to the highest evidence tier level that could be assigned to recommendations from each guideline. The sorting process is based on our previous method for classifying genomic applications (described in Clinical Pharmacology and Therapeutics, 2014), except that guideline documents rather than clinical scenarios are sorted according to evidence level. more

Recent Tier 1 Publications

2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death.
Katja Zeppenfeld et al. Eur Heart J 2022 43(40) 3997-4126
Consensus clinical management guidelines for acid sphingomyelinase deficiency (Niemann-Pick disease types A, B and A/B).
Tarekegn Geberhiwot et al. Orphanet J Rare Dis 2023 18(1) 85
2. Classification and Diagnosis of Diabetes: Standards of Care in Diabetes-2023.
Nuha A ElSayed et al. Diabetes care 2022 46(Suppl 1) S19-S40
Noninvasive prenatal screening (NIPS) for fetal chromosome abnormalities in a general-risk population: An evidence-based clinical guideline of the American College of Medical Genetics and Genomics (ACMG).
Dungan Jeffrey S et al. Genetics in medicine : official journal of the American College of Medical Genetics 2022
Genetic testing and counseling for the unexplained epilepsies: An evidence-based practice guideline of the National Society of Genetic Counselors.
Smith Lacey et al. Journal of genetic counseling 2022

Top 5 Most with Highest Altmetric Scores

Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement.
et al. JAMA 2021 325(19) 1965-1977
HER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma: Guideline From the College of American Pathologists, American Society for Clinical Pathology, and American Society of Clinical Oncology
Bartley AN, et al
Role of Genetic Testing for Inherited Prostate Cancer Risk: Philadelphia Prostate Cancer Consensus Conference 2017.
Giri Veda N et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2017 Dec JCO2017741173
Breast Cancer Screening in Women at Higher-Than-Average Risk: Recommendations From the ACR.
Monticciolo Debra L et al. Journal of the American College of Radiology : JACR 2018 Jan
Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer: US Preventive Services Task Force Recommendation Statement.
US Preventive Services Task Force et al. JAMA 2019 322(7) 652-665

Content Statistics

  • Total Publications: 525
    • Tier 1 Publications: 162
    • Tier 2 Publications: 345
    • Tier 3 Publications: 18
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