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Tier-Classified Guidelines Database


Tier Table Database|Home|PHGKB
Last data update: Aug 10, 2022. (Total: 497 Documents since 2012)
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Recent Uploaded Publications

Mismatch Repair and Microsatellite Instability Testing for Immune Checkpoint Inhibitor Therapy.
Bartley Angela N et al. Archives of pathology & laboratory medicine 2022

Organization:
Local Coverage Determination (LCD) for Lab-Developed Tests for Inherited Cancer Syndromes in Patients with Cancer
The Centers for Medicare & Medicaid Services (CMS)

Organization: The Centers for Medicare & Medicaid Services (CMS)
Local Coverage Determination (LCD) for Molecular Biomarkers to Risk-Stratify Patients at Increased Risk for Prostate Cancer
The Centers for Medicare & Medicaid Services (CMS)

Organization: The Centers for Medicare & Medicaid Services (CMS)
Local Coverage Determination (LCD) for Genetic Testing for Cardiovascular Disease
The Centers for Medicare & Medicaid Services (CMS)

Organization: The Centers for Medicare & Medicaid Services (CMS)
cancer predisposition risk assessment system
The U.S. Food and Drug Administration (FDA)
Organization: The U.S. Food and Drug Administration (FDA)
POMC/PCSK1/LEPR CDx Panel
The U.S. Food and Drug Administration (FDA)
Organization: The U.S. Food and Drug Administration (FDA)
ACMG SF v3.1 list for reporting of secondary findings in clinical exome and genome sequencing: A policy statement of the American College of Medical Genetics and Genomics (ACMG).
Miller David T et al. Genetics in medicine : official journal of the American College of Medical Genetics 2022 24(7) 1407-1414

Organization: American College of Medical Genetics and Genomics (ACMG)
Clinical evaluation and etiologic diagnosis of hearing loss: A clinical practice resource of the American College of Medical Genetics and Genomics (ACMG).
Li Marilyn M et al. Genetics in medicine : official journal of the American College of Medical Genetics 2022 24(7) 1392-1406

Organization: American College of Medical Genetics and Genomics (ACMG)
Consensus Recommendations of the German Consortium for Hereditary Breast and Ovarian Cancer.
Rhiem Kerstin et al. Breast care (Basel, Switzerland) 2022 17(2) 199-207

Organization: German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC)
Clinical and Genetic Evaluation of People with or at Risk of Hereditary ATTR Amyloidosis: An Expert Opinion and Consensus on Best Practice in Ireland and the UK.
Gillmore Julian D et al. Advances in therapy 2022

Organization: Expert Panel
European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) Expert Consensus Statement on the state of genetic testing for cardiac diseases.
Wilde Arthur A M et al. Heart rhythm 2022

Organization: European Heart Rhythm Association (EHRA) Heart Rhythm Society (HRS) Asia Pacific Heart Rhythm Society (APHRS) Latin American Heart Rhythm Society (LAHRS)
Expert Consensus on the Use of Prognostic Gene Expression Profiling Tests for the Management of Cutaneous Melanoma: Consensus from the Skin Cancer Prevention Working Group.
Farberg Aaron S et al. Dermatology and therapy 2022

Organization: The Skin Cancer Prevention Working Group
The Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for SLCO1B1, ABCG2, and CYP2C9 and statin-associated musculoskeletal symptoms.
Cooper-DeHoff Rhonda M et al. Clinical pharmacology and therapeutics 2022

Organization: Clinical Pharmacogenetics Implementation Consortium (CPIC)
Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update.
Lee Craig R et al. Clinical pharmacology and therapeutics 2022

Organization: Clinical Pharmacogenetics Implementation Consortium (CPIC)
next generation sequencing based tumor profiling test
The U.S. Food and Drug Administration (FDA)
Organization: The U.S. Food and Drug Administration (FDA)
rt-qpcr assay for mrna transcript immune biomarkers
The U.S. Food and Drug Administration (FDA)
Organization: The U.S. Food and Drug Administration (FDA)
lynch syndrome test system
The U.S. Food and Drug Administration (FDA)
Organization: The U.S. Food and Drug Administration (FDA)
Immunohistochemistry Assay, Antibody, Ki-67
The U.S. Food and Drug Administration (FDA)
Organization: The U.S. Food and Drug Administration (FDA)
Immunohistochemistry Test, Dna Mismatch Repair (Mmr) Protein Assay
The U.S. Food and Drug Administration (FDA)
Organization: The U.S. Food and Drug Administration (FDA)
Next Generation Sequencing Oncology Panel, Somatic Or Germline Variant Detection System
The U.S. Food and Drug Administration (FDA)
Organization: The U.S. Food and Drug Administration (FDA)

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About

This database contains guidelines from the Genomics and Precision Health Database, sorted according to the highest evidence tier level that could be assigned to recommendations from each guideline. The sorting process is based on our previous method for classifying genomic applications (described in Clinical Pharmacology and Therapeutics, 2014), except that guideline documents rather than clinical scenarios are sorted according to evidence level. more

Recent Tier 1 Publications

Local Coverage Determination (LCD) for Genetic Testing for Cardiovascular Disease
The Centers for Medicare & Medicaid Services (CMS)
Local Coverage Determination (LCD) for Lab-Developed Tests for Inherited Cancer Syndromes in Patients with Cancer
The Centers for Medicare & Medicaid Services (CMS)
Local Coverage Determination (LCD) for Molecular Biomarkers to Risk-Stratify Patients at Increased Risk for Prostate Cancer
The Centers for Medicare & Medicaid Services (CMS)
POMC/PCSK1/LEPR CDx Panel
The U.S. Food and Drug Administration (FDA)
Immunohistochemistry Assay, Antibody, Ki-67
The U.S. Food and Drug Administration (FDA)

Top 5 Most with Highest Altmetric Scores

Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement.
et al. JAMA 2021 325(19) 1965-1977
Role of Genetic Testing for Inherited Prostate Cancer Risk: Philadelphia Prostate Cancer Consensus Conference 2017.
Giri Veda N et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2017 Dec JCO2017741173
Breast Cancer Screening in Women at Higher-Than-Average Risk: Recommendations From the ACR.
Monticciolo Debra L et al. Journal of the American College of Radiology : JACR 2018 Jan
Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer: US Preventive Services Task Force Recommendation Statement.
US Preventive Services Task Force et al. JAMA 2019 322(7) 652-665
Molecular Biomarkers for the Evaluation of Colorectal Cancer: Guideline From the American Society for Clinical Pathology, College of American Pathologists, Association for Molecular Pathology, and American Society of Clinical Oncology.
Sepulveda Antonia R et al. Archives of pathology & laboratory medicine 2017 Feb

Content Statistics

  • Total Publications: 497
    • Tier 1 Publications: 151
    • Tier 2 Publications: 328
    • Tier 3 Publications: 18
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