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Tier-Classified Guidelines Database


Tier Table Database|Home|PHGKB
Last data update: Jul 07, 2021. (Total: 403 Documents since 2012)
   dataset

Recent Uploaded Publications

Exome and genome sequencing for pediatric patients with congenital anomalies or intellectual disability: an evidence-based clinical guideline of the American College of Medical Genetics and Genomics (ACMG).
Manickam Kandamurugu et al. Genetics in medicine : official journal of the American College of Medical Genetics 2021

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2020 APHRS/HRS expert consensus statement on the investigation of decedents with sudden unexplained death and patients with sudden cardiac arrest, and of their families.
Stiles Martin K et al. Journal of arrhythmia 2021 37(3) 481-534

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European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender.
Seppälä T T et al. The British journal of surgery 2021 108(5) 484-498

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International consensus on initial screening and follow-up of asymptomatic SDHx mutation carriers.
Amar Laurence et al. Nature reviews. Endocrinology 2021

Organization:
ACMG SF v3.0 list for reporting of secondary findings in clinical exome and genome sequencing: a policy statement of the American College of Medical Genetics and Genomics (ACMG).
Miller David T et al. Genetics in medicine : official journal of the American College of Medical Genetics 2021

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Management of individuals with germline variants in PALB2: a clinical practice resource of the American College of Medical Genetics and Genomics (ACMG).
Tischkowitz Marc et al. Genetics in medicine : official journal of the American College of Medical Genetics 2021

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Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement.
et al. JAMA 2021 325(19) 1965-1977

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ASH ISTH NHF WFH 2021 guidelines on the diagnosis of von Willebrand disease.
James Paula D et al. Blood advances 2021 Jan 5(1) 280-300

Organization: The American Society of Hematology The International Society on Thrombosis and Haemostasis (ISTH) National Hemophilia Foundation (NHF) World Federation of Hemophilia (WFH)
Focused Revision: ACMG practice resource: Genetic evaluation of short stature.
Mintz Cassie S et al. Genetics in medicine : official journal of the American College of Medical Genetics 2021 Jan

Organization: The American College of Medical Genetics and Genomics (ACMG)
Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
Daly Mary B et al. Journal of the National Comprehensive Cancer Network : JNCCN 2021 Jan 19(1) 77-102

Organization: The National Comprehensive Cancer Network (NCCN)
Consumer Testing for Disease Risk: ACOG Committee Opinion, Number 816.
et al. Obstetrics and gynecology 2021 Jan 137(1) e1-e6

Organization: The American College of Obstetricians and Gynecologists (ACOG)
Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6, OPRM1, and COMT genotype and select opioid therapy.
Crews Kristine R et al. Clinical pharmacology and therapeutics 2021 Jan

Organization: The Clinical Pharmacogenetics Implementation Consortium (CPIC)
Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction of DPYD and fluoropyrimidines.
Lunenburg Carin A T C et al. European journal of human genetics : EJHG 2019 28(4) 508-517

Organization: Dutch Pharmacogenetics Working Group (DPWG)
Fluoropyrimidine chemotherapy: recommendations for DPYD genotyping and therapeutic drug monitoring of the Swiss Group of Pharmacogenomics and Personalised Therapy.
Hamzic Seid et al. Swiss medical weekly 2020 Nov 150w20375

Organization: Expert Panel
2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
Steve R Ommen, et al. Journal of the American College of Cardiology 2020 Nov

Organization: The American Heart Association (AHA) The American College of Cardiology (ACC)
Myeloid/Lymphoid Neoplasms with Eosinophilia and TK Fusion Genes, Version 3.2021, NCCN Clinical Practice Guidelines in Oncology.
Gerds Aaron T et al. Journal of the National Comprehensive Cancer Network : JNCCN 2020 Sep 18(9) 1248-1269

Organization: NCCN Clinical Practice Guidelines in Oncology
Genetics, prevalence, screening and confirmation of primary aldosteronism: a position statement and consensus of the Working Group on Endocrine Hypertension of The European Society of Hypertension.
Mulatero Paolo et al. Journal of hypertension 2020 Oct 38(10) 1919-1928

Organization: The European Society of Hypertension
Recommendations for Pregnancy in Rare Inherited Anemias.
Taher Ali T et al. HemaSphere 2020 Aug 4(4) e446

Organization: Expert Panel
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: A report from the ESMO Precision Medicine Working Group.
Mosele F et al. Annals of oncology : official journal of the European Society for Medical Oncology 2020 Jul

Organization: The European Society for Medical Oncology (ESMO)
Committee Opinion No. 406: Prenatal testing after IVF with preimplantation genetic testing for aneuploidy.
Zwingerman Rhonda et al. Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC 2020 Aug

Organization: Expert Panel

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About

This database contains guidelines from the Genomics and Precision Health Database, sorted according to the highest evidence tier level that could be assigned to recommendations from each guideline. The sorting process is based on our previous method for classifying genomic applications (described in Clinical Pharmacology and Therapeutics, 2014), except that guideline documents rather than clinical scenarios are sorted according to evidence level. more

Recent Tier 1 Publications

Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
Daly Mary B et al. Journal of the National Comprehensive Cancer Network : JNCCN 2021 Jan 19(1) 77-102
2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
Steve R Ommen, et al. Journal of the American College of Cardiology 2020 Nov

American Society of Hematology 2020 guidelines for sickle cell disease: prevention, diagnosis, and treatment of cerebrovascular disease in children and adults.
DeBaun M R et al. Blood advances 2020 Apr 4(8) 1554-1588
JSCO/ESMO/ASCO/JSMO/TOS: International expert consensus recommendations for tumour-agnostic treatments in patients with solid tumours with microsatellite instability or NTRK fusions.
Yoshino T et al. Annals of oncology : official journal of the European Society for Medical Oncology 2020 Apr

Management of Hereditary Breast Cancer: American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology Guideline.
Tung Nadine M et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2020 Apr JCO2000299

Top 5 Most with Highest Altmetric Scores

Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement.
et al. JAMA 2021 325(19) 1965-1977
Role of Genetic Testing for Inherited Prostate Cancer Risk: Philadelphia Prostate Cancer Consensus Conference 2017.
Giri Veda N et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2017 Dec JCO2017741173
Breast Cancer Screening in Women at Higher-Than-Average Risk: Recommendations From the ACR.
Monticciolo Debra L et al. Journal of the American College of Radiology : JACR 2018 Jan
Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer: US Preventive Services Task Force Recommendation Statement.
US Preventive Services Task Force et al. JAMA 2019 322(7) 652-665
Molecular Biomarkers for the Evaluation of Colorectal Cancer: Guideline From the American Society for Clinical Pathology, College of American Pathologists, Association for Molecular Pathology, and American Society of Clinical Oncology.
Sepulveda Antonia R et al. Archives of pathology & laboratory medicine 2017 Feb

Content Statistics

  • Total Publications: 403
    • Tier 1 Publications: 96
    • Tier 2 Publications: 295
    • Tier 3 Publications: 12
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