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Tier-Classified Guidelines Database


Tier Table Database|Home|PHGKB
Last data update: Jan 19, 2023. (Total: 509 Documents since 2012)
   dataset

Recent Uploaded Publications

International Consensus Guideline on Small for Gestational Age (SGA): Etiology and Management from Infancy to Early Adulthood.
Hokken-Koelega Anita C S et al. Endocrine reviews 2023

Organization:
Noninvasive prenatal screening (NIPS) for fetal chromosome abnormalities in a general-risk population: An evidence-based clinical guideline of the American College of Medical Genetics and Genomics (ACMG).
Dungan Jeffrey S et al. Genetics in medicine : official journal of the American College of Medical Genetics 2022

Organization:
Dutch pharmacogenetics working group (DPWG) guideline for the gene-drug interaction of CYP2D6 and COMT with atomoxetine and methylphenidate.
Nijenhuis Marga et al. European journal of human genetics : EJHG 2022

Organization:
Dutch pharmacogenetics working group (DPWG) guideline for the gene-drug interaction between UGT1A1 and irinotecan.
Hulshof Emma C et al. European journal of human genetics : EJHG 2022

Organization:
Genetic testing and counseling for the unexplained epilepsies: An evidence-based practice guideline of the National Society of Genetic Counselors.
Smith Lacey et al. Journal of genetic counseling 2022

Organization: National Society of Genetic Counselors (NSGC)
Dutch pharmacogenetics working group guideline for the gene-drug interaction of ABCG2, HLA-B and Allopurinol, and MTHFR, folic acid and methotrexate.
van der Pol Karel H et al. European journal of human genetics : EJHG 2022

Organization: Dutch Pharmacogenetics Working Group (DPWG)
Mismatch Repair and Microsatellite Instability Testing for Immune Checkpoint Inhibitor Therapy.
Bartley Angela N et al. Archives of pathology & laboratory medicine 2022

Organization: College of American Pathologists (CAP)
Local Coverage Determination (LCD) for Lab-Developed Tests for Inherited Cancer Syndromes in Patients with Cancer
The Centers for Medicare & Medicaid Services (CMS)

Organization: Centers for Medicare & Medicaid Services (CMS)
Local Coverage Determination (LCD) for Molecular Biomarkers to Risk-Stratify Patients at Increased Risk for Prostate Cancer
The Centers for Medicare & Medicaid Services (CMS)

Organization: Centers for Medicare & Medicaid Services (CMS)
Local Coverage Determination (LCD) for Genetic Testing for Cardiovascular Disease
The Centers for Medicare & Medicaid Services (CMS)

Organization: Centers for Medicare & Medicaid Services (CMS)
cancer predisposition risk assessment system
The U.S. Food and Drug Administration (FDA)
Organization: U.S. Food and Drug Administration (FDA)
POMC/PCSK1/LEPR CDx Panel
The U.S. Food and Drug Administration (FDA)
Organization: U.S. Food and Drug Administration (FDA)
ACMG SF v3.1 list for reporting of secondary findings in clinical exome and genome sequencing: A policy statement of the American College of Medical Genetics and Genomics (ACMG).
Miller David T et al. Genetics in medicine : official journal of the American College of Medical Genetics 2022 24(7) 1407-1414

Organization: American College of Medical Genetics and Genomics (ACMG)
Clinical evaluation and etiologic diagnosis of hearing loss: A clinical practice resource of the American College of Medical Genetics and Genomics (ACMG).
Li Marilyn M et al. Genetics in medicine : official journal of the American College of Medical Genetics 2022 24(7) 1392-1406

Organization: American College of Medical Genetics and Genomics (ACMG)
Consensus Recommendations of the German Consortium for Hereditary Breast and Ovarian Cancer.
Rhiem Kerstin et al. Breast care (Basel, Switzerland) 2022 17(2) 199-207

Organization: German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC)
Clinical and Genetic Evaluation of People with or at Risk of Hereditary ATTR Amyloidosis: An Expert Opinion and Consensus on Best Practice in Ireland and the UK.
Gillmore Julian D et al. Advances in therapy 2022

Organization: Expert Panel
European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) Expert Consensus Statement on the state of genetic testing for cardiac diseases.
Wilde Arthur A M et al. Heart rhythm 2022

Organization: European Heart Rhythm Association (EHRA) Heart Rhythm Society (HRS) Asia Pacific Heart Rhythm Society (APHRS) Latin American Heart Rhythm Society (LAHRS)
Expert Consensus on the Use of Prognostic Gene Expression Profiling Tests for the Management of Cutaneous Melanoma: Consensus from the Skin Cancer Prevention Working Group.
Farberg Aaron S et al. Dermatology and therapy 2022

Organization: Skin Cancer Prevention Working Group
The Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for SLCO1B1, ABCG2, and CYP2C9 and statin-associated musculoskeletal symptoms.
Cooper-DeHoff Rhonda M et al. Clinical pharmacology and therapeutics 2022

Organization: Clinical Pharmacogenetics Implementation Consortium (CPIC)
Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update.
Lee Craig R et al. Clinical pharmacology and therapeutics 2022

Organization: Clinical Pharmacogenetics Implementation Consortium (CPIC)

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About

This database contains guidelines from the Genomics and Precision Health Database, sorted according to the highest evidence tier level that could be assigned to recommendations from each guideline. The sorting process is based on our previous method for classifying genomic applications (described in Clinical Pharmacology and Therapeutics, 2014), except that guideline documents rather than clinical scenarios are sorted according to evidence level. more

Recent Tier 1 Publications

Genetic testing and counseling for the unexplained epilepsies: An evidence-based practice guideline of the National Society of Genetic Counselors.
Smith Lacey et al. Journal of genetic counseling 2022

Mismatch Repair and Microsatellite Instability Testing for Immune Checkpoint Inhibitor Therapy.
Bartley Angela N et al. Archives of pathology & laboratory medicine 2022

Local Coverage Determination (LCD) for Molecular Biomarkers to Risk-Stratify Patients at Increased Risk for Prostate Cancer
The Centers for Medicare & Medicaid Services (CMS)
Local Coverage Determination (LCD) for Genetic Testing for Cardiovascular Disease
The Centers for Medicare & Medicaid Services (CMS)
Local Coverage Determination (LCD) for Lab-Developed Tests for Inherited Cancer Syndromes in Patients with Cancer
The Centers for Medicare & Medicaid Services (CMS)

Top 5 Most with Highest Altmetric Scores

Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement.
et al. JAMA 2021 325(19) 1965-1977
HER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma: Guideline From the College of American Pathologists, American Society for Clinical Pathology, and American Society of Clinical Oncology
Bartley AN, et al
Role of Genetic Testing for Inherited Prostate Cancer Risk: Philadelphia Prostate Cancer Consensus Conference 2017.
Giri Veda N et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2017 Dec JCO2017741173
Breast Cancer Screening in Women at Higher-Than-Average Risk: Recommendations From the ACR.
Monticciolo Debra L et al. Journal of the American College of Radiology : JACR 2018 Jan
Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer: US Preventive Services Task Force Recommendation Statement.
US Preventive Services Task Force et al. JAMA 2019 322(7) 652-665

Content Statistics

  • Total Publications: 509
    • Tier 1 Publications: 158
    • Tier 2 Publications: 333
    • Tier 3 Publications: 18
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