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Tier-Classified Guidelines Database


Tier Table Database|Home|PHGKB
Last data update: Oct 10, 2019. (Total: 376 Documents since 2012)
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Recent Uploaded Publications

Guideline recommendations for diagnosis and clinical management of Ring14 syndrome-first report of an ad hoc task force.
Rinaldi Berardo et al. Orphanet journal of rare diseases 2017 12(1) 69

Organization:
Medication Use to Reduce Risk of Breast Cancer- US Preventive Services Task Force Recommendation Statement
USPSTF Recommendation, JAMA, September 3, 2019
Organization: The U.S. Preventive Services Task Force (USPSTF)
Recommendations from a Portuguese Expert Group for Discontinuation of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia Patients in Clinical Practice.
Almeida Antonio et al. Acta medica portuguesa 2019 Aug 32(7-8) 550-557

Organization: Expert Panel
Molecular testing for advanced non-small cell lung cancer in Malaysia: Consensus statement from the College of Pathologists, Academy of Medicine Malaysia, the Malaysian Thoracic Society, and the Malaysian Oncological Society.
Rajadurai Pathmanathan et al. Lung cancer (Amsterdam, Netherlands) 2019 Aug 13665-73

Organization: Expert Panel
Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer: US Preventive Services Task Force Recommendation Statement.
US Preventive Services Task Force et al. JAMA 2019 322(7) 652-665

Organization: The U.S. Preventive Services Task Force (USPSTF)
Clinical management of cutaneous adverse events in patients on targeted anticancer therapies and immunotherapies: a national consensus statement by the Spanish Academy of Dermatology and Venereology and the Spanish Society of Medical Oncology.
Grávalos C et al. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2019 May 21(5) 556-571

Organization: The Spanish Society of Medical Oncology (SSMO) The Spanish Academy of Dermatology and Venereology (ILDS)
Local Coverage Determination (LCD): Biomarker Testing for Neuroendocrine Tumors/Neoplasms (L37851)
The U.S. Centers for Medicare & Medicaid Services

Organization: The Centers for Medicare & Medicaid Services (CMS)
ACG Clinical Guideline: Hereditary Hemochromatosis.
Kowdley Kris V et al. The American journal of gastroenterology 2019 Jul

Organization: The American College of Gastroenterology (ACG)
Consensus Guidelines on Genetic` Testing for Hereditary Breast Cancer from the American Society of Breast Surgeons.
Manahan Eric R et al. Annals of surgical oncology 2019 Jul

Organization: The American Society of Breast Surgeons (ASBrS)
Endoscopic management of polyposis syndromes: European Society of Gastrointestinal Endoscopy (ESGE) guideline.
van Leerdam Monique E et al. Endoscopy 2019 Jul

Organization: The European Society of Gastrointestinal Endoscopy (ESGE)
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen Ezra E W et al. Journal for immunotherapy of cancer 2019 Jul 7(1) 184

Organization: The Society for Immunotherapy of Cancer (SITC)
Somatic gene mutation detection system (P180043)
The U.S. Food & Drug Administration
Organization: The U.S. Food and Drug Administration (FDA)
Prostrate cancer genes nucleic acid amplification test system (P100033)
The U.S. Food & Drug Administration
Organization: The U.S. Food and Drug Administration (FDA)
Cancer predisposition risk assessment system (K182784)
The U.S. Food & Drug Administration
Organization: The U.S. Food and Drug Administration (FDA)
Somatic gene mutation detection system (P190004)
The U.S. Food & Drug Administration
Organization: The U.S. Food and Drug Administration (FDA)
Somatic gene mutation detection system (P190001)
The U.S. Food & Drug Administration
Organization: The U.S. Food and Drug Administration (FDA)
Japan Society of Clinical Oncology provisional clinical opinion for the diagnosis and use of immunotherapy in patients with deficient DNA mismatch repair tumors, cooperated by Japanese Society of Medical Oncology, First Edition.
Mishima Saori et al. International journal of clinical oncology 2019 Jul

Organization: The Japanese Society of Medical Oncology
Draft Recommendation Statement: Abdominal Aortic Aneurysm: Screening,
U.S. Preventive Services, June 2019
Organization: The U.S. Preventive Services Task Force (USPSTF)
Treating HR+/HER2- breast cancer in premenopausal Asian women: Asian Breast Cancer Cooperative Group 2019 Consensus and position on ovarian suppression.
Yeo Winnie et al. Breast cancer research and treatment 2019 Jul

Organization: Expert Panel
International best practice for the evaluation of responsiveness to sapropterin dihydrochloride in patients with phenylketonuria.
Muntau Ania C et al. Molecular genetics and metabolism 2019 127(1) 1-11

Organization: Expert Panel

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About

This database contains guidelines from the Genomics and Precision Health Database, sorted according to the highest evidence tier level that could be assigned to recommendations from each guideline. The sorting process is based on our previous method for classifying genomic applications (described in Clinical Pharmacology and Therapeutics, 2014), except that guideline documents rather than clinical scenarios are sorted according to evidence level. more

Recent Tier 1 Publications

Medication Use to Reduce Risk of Breast Cancer- US Preventive Services Task Force Recommendation Statement
USPSTF Recommendation, JAMA, September 3, 2019
Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer: US Preventive Services Task Force Recommendation Statement.
US Preventive Services Task Force et al. JAMA 2019 322(7) 652-665
Somatic gene mutation detection system (P180043)
The U.S. Food & Drug Administration
Prostrate cancer genes nucleic acid amplification test system (P100033)
The U.S. Food & Drug Administration
Cancer predisposition risk assessment system (K182784)
The U.S. Food & Drug Administration

Top 5 Most Viewed

Meta-analysis and multidisciplinary consensus statement: exome sequencing is a first-tier clinical diagnostic test for individuals with neurodevelopmental disorders.
Srivastava Siddharth et al. Genetics in medicine : official journal of the American College of Medical Genetics 2019 Jun

(65 reads)
Draft Recommendation Statement and Draft Evidence Review: Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer
The U.S. Preventive Services Task Force

(60 reads)
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 Genotype and Atomoxetine Therapy.
Brown Jacob T et al. Clinical pharmacology and therapeutics 2019 Feb

(58 reads)
Use of Biomarkers to Guide Decisions on Adjuvant Systemic Therapy for Women With Early-Stage Invasive Breast Cancer: ASCO Clinical Practice Guideline Update-Integration of Results From TAILORx.
Andre Fabrice et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2019 May JCO1900945

(57 reads)
2019 HRS Expert Consensus Statement on Evaluation, Risk Stratification, and Management of Arrhythmogenic Cardiomyopathy.
Towbin JA, et al. Heart Rhythm. 2019 May 9.

(56 reads)

Content Statistics

  • Total Publications: 376
    • Tier 1 Publications: 163
    • Tier 2 Publications: 201
    • Tier 3 Publications: 11
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