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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.
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Archived Hot Topics of the Day By Date
Joint COVID-19 and influenza-like illness forecasts in the United States using internet search information.
Simin Ma et al. Communications medicine 2023 3 (1) 39
(Posted: Mar-29-2023 8AM)
Determinants of COVID-19 vaccine fatigue.
Tanja A Stamm et al. Nature medicine 2023 3
(Posted: Mar-28-2023 6AM)
Rare Primary Immunodeficiency Diseases and COVID-19: Evolving Insights and Implications for Clinical and Public Health Practice
E Drzymalla et al, CDC Blog Post, March 27, 2023
(Posted: Mar-27-2023 9AM)
Predicting vaccine effectiveness against severe COVID-19 over time and against variants: a meta-analysis.
Deborah Cromer et al. Nature communications 2023 3 (1) 1633
(Posted: Mar-27-2023 7AM)
People who catch Omicron are less likely to get Long Covid Vaccination, virus biology may be driving down risk
J Couzin-Frankel, Science, March 2023
(Posted: Mar-25-2023 8AM)
Maternal third dose of BNT162b2 mRNA vaccine and risk of infant COVID-19 hospitalization
M Lipshhuetz et al, Nature Medicine, March 23, 2023
(Posted: Mar-24-2023 6AM)
Neutralization of BQ.1, BQ.1.1, and XBB with RBD-Dimer Vaccines.
Dedong Li et al. The New England journal of medicine 2023 3 (12) 1142-1145
(Posted: Mar-23-2023 6AM)
Heterogeneous Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19.
Ewan C Goligher et al. JAMA 2023 3
(Posted: Mar-22-2023 7AM)
COVID-19 Forecasting and Mathematical Modeling
CDC, March 2023
(Posted: Mar-20-2023 2PM)
School-Based Interventions to Increase Student COVID-19 Vaccination Coverage in Public School Populations with Low Coverage - Seattle, Washington, December 2021-June 2022.
Tarayn Fairlie et al. MMWR. Morbidity and mortality weekly report 2023 3 (11) 283-287
(Posted: Mar-20-2023 2PM)
Comparative effectiveness of BNT162b2 versus mRNA-1273 covid-19 vaccine boosting in England: matched cohort study in OpenSAFELY-TPP.
William J Hulme et al. BMJ (Clinical research ed.) 2023 3 e072808
(Posted: Mar-18-2023 3PM)
Estimation of COVID-19 mRNA Vaccine Effectiveness and COVID-19 Illness and Severity by Vaccination Status During Omicron BA.4 and BA.5 Sublineage Periods
RL Gelles et al, JAMA Network Open, March 15, 2023
(Posted: Mar-15-2023 4PM)
Host genomics for better infectious disease treatment
H Carr, PHG Foundation, March 6, 2023
(Posted: Mar-10-2023 3PM)
An Explainable Host Genetic Severity Predictor Model for COVID-19 Patients
A Onoja et al, MEDRXIV, March 9, 2023
(Posted: Mar-10-2023 3PM)
Comparison of Symptoms Associated With SARS-CoV-2 Variants Among Children in Canada.
Madeleine W Sumner et al. JAMA network open 2023 3 (3) e232328
(Posted: Mar-09-2023 8PM)
Forecasting the trajectory of the COVID-19 pandemic into 2023 under plausible variant and intervention scenarios: a global modelling study
R Reiner et al, MEDRXIV, March 9, 2023
(Posted: Mar-09-2023 1PM)
Effectiveness of mRNA COVID-19 vaccine booster doses against Omicron severe outcomes.
Ramandip Grewal et al. Nature communications 2023 3 (1) 1273
(Posted: Mar-08-2023 6PM)
Phenome-wide association study to explore the long-term symptoms after infection with novel coronavirus in the UK Biobank
K Zhang et al, MEDRXIV, March 5, 2023
(Posted: Mar-06-2023 6PM)
Spatially-resolved wastewater-based surveillance enables COVID-19 case localization across a university campus, and confirms lower SARS-CoV-2 RNA burden relative to the surrounding community
J Lee et al, MEDRXIV, March 6, 2023
(Posted: Mar-06-2023 6PM)
A circulating proteome-informed prognostic model of COVID-19 disease activity that relies on routinely available clinical laboratories
W Ma et al, MEDRXIV, March 6, 2023
(Posted: Mar-06-2023 6PM)
COVID-19 in non-hospitalised adults caused by either SARS-CoV-2 sub-variants Omicron BA.1,2,5 and Delta associates with similar illness duration, symptom severity and viral kinetics, irrespective of vaccination history
H Townsley et al, MEDRXIV, March 6, 2023
(Posted: Mar-06-2023 6PM)
Safety and immunogenicity of the protein-based PHH-1V compared to BNT162b2 as a heterologous SARS-CoV-2 booster vaccine in adults vaccinated against COVID-19: a multicentre, randomised, double-blind, non-inferiority phase IIb trial
J Corominas et al, MEDRXIV, March 2, 2023
(Posted: Mar-04-2023 8AM)
An AI-enabled research support tool for the classification system of COVID-19
A Tiwari et al, Front Public Health, March 3, 2023
(Posted: Mar-03-2023 4PM)
Predicting the efficacy of variant-modified COVID-19 vaccine boosters.
David S Khoury et al. Nature medicine 2023 3
(Posted: Mar-03-2023 9AM)
Financing covid-19 mRNA vaccines.
Victor Roy et al. BMJ (Clinical research ed.) 2023 3 p413
(Posted: Mar-02-2023 9AM)
US public investment in development of mRNA covid-19 vaccines: retrospective cohort study.
Hussain S Lalani et al. BMJ (Clinical research ed.) 2023 3 e073747
(Posted: Mar-02-2023 9AM)
Estimated Effectiveness of Postpartum Maternal Messenger RNA COVID-19 Vaccination Against Delta and Omicron SARS-CoV-2 Infection and Hospitalization in Infants Younger Than 6 Months
SCJ Jorgenson et al, JAMA Pediatrics, February 27, 2023
(Posted: Feb-27-2023 11AM)
Cellular and molecular heterogeneities and signatures, and pathological trajectories of fatal COVID-19 lungs defined by spatial single-cell transcriptome analysis
A Das et al, MEDRXIV, February 26, 2021
(Posted: Feb-27-2023 9AM)
Effect of Predeparture Testing on Postarrival SARS-CoV-2-Positive Test Results Among International Travelers - CDC Traveler-Based Genomic Surveillance Program, Four U.S. Airports, March-September 2022.
Stephen M Bart et al. MMWR. Morbidity and mortality weekly report 2023 2 (8) 206-209
(Posted: Feb-24-2023 7AM)
Multilevel determinants of Covid-19 vaccine hesitancy and undervaccination among marginalized populations in the United States: A scoping review
PA Newman et al, MEDRXIV, February 23, 2023
(Posted: Feb-24-2023 7AM)
A unique cytotoxic CD4+ T cells signature defines critical COVID-19
S Baird et al, MEDRXIV, February 23, 2023
(Posted: Feb-24-2023 7AM)
Epidemiological impacts of the NHS COVID-19 app in England and Wales throughout its first year
M Kendall et al, Nat Comm, February 22, 2023
(Posted: Feb-22-2023 6AM)
A third vaccine dose equalizes the levels of effectiveness and immunogenicity of heterologous or homologous COVID-19 vaccine regimens
N Guibert et al, MEDRXIV, February 21, 2023
(Posted: Feb-22-2023 6AM)
Intrinsic and effective severity of COVID-19 cases infected with the ancestral strain and Omicron BA.2 variant in Hong Kong
JY Wong et al, MEDRXIV< February 21, 2023
(Posted: Feb-22-2023 6AM)
Design and Implementation of the All of Us Research Program COVID-19 Participant Experience (COPE) Survey.
Claire E Schulkey et al. American journal of epidemiology 2023 2
(Posted: Feb-20-2023 6AM)
COVID-19 Vaccination Coverage and Demographic Characteristics of Infants and Children Aged 6 Months-4 Years - United States, June 20-December 31, 2022.
Bhavini Patel Murthy et al. MMWR. Morbidity and mortality weekly report 2023 2 (7) 183-189
(Posted: Feb-17-2023 6AM)
COVID-19 Bivalent Booster Vaccination Coverage and Intent to Receive Booster Vaccination Among Adolescents and Adults - United States, November-December 2022.
Peng-Jun Lu et al. MMWR. Morbidity and mortality weekly report 2023 2 (7) 190-198
(Posted: Feb-17-2023 6AM)
The role of wastewater-based epidemiology for SARS-CoV-2 in developing countries: cumulative evidence from South Africa supports sentinel site surveillance to guide public health decision-making
SJI Jaja et al, MEDRXIV, February 15, 2023
(Posted: Feb-17-2023 6AM)
Polygenic Risk Scores for Asthma and Allergic Disease Associate with COVID-19 Severity in 9/11 Responders
M Wasczuk et al, MEDRXIV, February 16, 2023
(Posted: Feb-17-2023 6AM)
Ischemic stroke after COVID-19 bivalent vaccine administration in patients aged 65 years and older: analysis of nation-wide patient electronic health records in the United States
M Gorenflo et al, MEDRXIV, February 14, 2023
(Posted: Feb-16-2023 6AM)
Association of COVID-19 Vaccination With Risk for Incident Diabetes After COVID-19 Infection.
Alan C Kwan et al. JAMA network open 2023 2 (2) e2255965
(Posted: Feb-16-2023 6AM)
Evaluation of BNT162b2 Covid-19 Vaccine in Children Younger than 5 Years of Age.
Flor M Muñoz et al. The New England journal of medicine 2023 2 (7) 621-634
(Posted: Feb-16-2023 6AM)
Questions Remain About What SARS-CoV-2 Variants Should Go Into the Annual COVID-19 Vaccines Proposed by the FDA.
Rita Rubin et al. JAMA 2023 2
(Posted: Feb-16-2023 6AM)
Forecasting hospital-level COVID-19 admissions using real-time mobility data
B Klein et al, Comm Medicine, February 14, 2023
(Posted: Feb-15-2023 7AM)
Long-term effectiveness of COVID-19 vaccines against infections, hospitalisations, and mortality in adults: findings from a rapid living systematic evidence synthesis and meta-analysis up to December, 2022.
Nana Wu et al. The Lancet. Respiratory medicine 2023 2
(Posted: Feb-14-2023 7AM)
Divergence of wastewater SARS-CoV-2 and reported laboratory-confirmed COVID-19 incident case data coincident with wide-spread availability of at-home COVID-19 antigen tests
A Boehm et al, MEDRXIV< February 13, 2023
(Posted: Feb-14-2023 7AM)
Relative effectiveness of BNT162b2, mRNA-1273, and Ad26.COV2.S vaccines and homologous boosting in preventing COVID-19 in adults in the US
H Nguyen et al, MEDRXIV, February 12, 2023
(Posted: Feb-13-2023 7AM)
Maternal mRNA covid-19 vaccination during pregnancy and delta or omicron infection or hospital admission in infants: test negative design study.
Sarah C J Jorgensen et al. BMJ (Clinical research ed.) 2023 2 e074035
(Posted: Feb-12-2023 7AM)
Vaccination status and long COVID symptoms in patients discharged from hospital.
Teresa Cristina D C Nascimento et al. Scientific reports 2023 2 (1) 2481
(Posted: Feb-12-2023 7AM)
COVID-19 Incidence and Mortality Among Unvaccinated and Vaccinated Persons Aged ≥12 Years by Receipt of Bivalent Booster Doses and Time Since Vaccination - 24 U.S. Jurisdictions, October 3, 2021-December 24, 2022.
Amelia G Johnson et al. MMWR. Morbidity and mortality weekly report 2023 2 (6) 145-152
(Posted: Feb-10-2023 6AM)
The impacts of SARS-CoV-2 vaccine dose separation and targeting on the COVID-19 epidemic in England
MJ Keeling et al, Nature Comm, February 10, 2023
(Posted: Feb-10-2023 6AM)
Factors Associated with Stroke after COVID-19 Vaccination: A Statewide Analysis
F Nahab et al, MEDRXIV, February 9, 2023
(Posted: Feb-10-2023 6AM)
Machine-learning-aided multiplexed nanobiosensor for COVID-19 population immunity profiling
A Beisenova et al, MEDRXIV, February 8, 2023
(Posted: Feb-09-2023 6AM)
Use of wastewater metrics to track COVID-19 in the U.S.: a national time-series analysis over the first three quarters of 2022
M Varkila et al, MEDRXIV, February 8, 2023
(Posted: Feb-09-2023 6AM)
Characterisation of SARS-CoV-2 variants in Beijing during 2022: an epidemiological and phylogenetic analysis
Y Pan et al, The Lancet, February 8, 2023
(Posted: Feb-08-2023 0PM)
The NIH-led research response to COVID-19.
Francis Collins et al. Science (New York, N.Y.) 2023 2 (6631) 441-444
(Posted: Feb-08-2023 9AM)
Associations of COVID-19 Symptoms with Omicron Subvariants BA.2 and BA.5, Host Status, and Clinical Outcomes: A Registry-Based Observational Study in Sapporo, Japan
S Nakabuko et al, MEDRXIV, February 7, 2023
(Posted: Feb-08-2023 6AM)
A scoping review of the impacts of COVID-19 physical distancing measures on vulnerable population groups.
Lili Li et al. Nature communications 2023 2 (1) 599
(Posted: Feb-07-2023 8AM)
Unlocking life-threatening COVID-19 through two types of inborn errors of type I IFNs.
Jean-Laurent Casanova et al. The Journal of clinical investigation 2023 1 (3)
(Posted: Feb-05-2023 11AM)
How quickly does COVID immunity fade? What scientists know.
Cassandra Willyard et al. Nature 2023 2
(Posted: Feb-04-2023 7AM)
Global generalisability of AI-driven COVID-19 vaccination policies: a cross-sectional observational study
R Awasthi et al, MEDRXIV, February 2, 2023
(Posted: Feb-03-2023 7AM)
Inequities in COVID-19 vaccine and booster coverage across Massachusetts ZIP codes after the emergence of Omicron: A population-based cross-sectional study.
Jacob Bor et al. PLoS medicine 2023 1 (1) e1004167
(Posted: Feb-02-2023 7AM)
The next generation of coronavirus vaccines: a graphical guide
E Callaway, Nature, February 1, 2023
(Posted: Feb-01-2023 6AM)
Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity
S Yojoshi et al, MEDRXIV, January 31, 2023
(Posted: Feb-01-2023 6AM)
The effect of previous SARS-CoV-2 infection and COVID-19 vaccination on SARS-CoV-2 Omicron infection and relation with serological response – a prospective cohort study
B de Gier et al, MEDRXIV, January 31, 2023
(Posted: Feb-01-2023 6AM)
A modeling-based approach to optimize COVID-19 vaccine dosing schedules for improved protection
P Dogra et al, MEDRXIV, January 31, 2023
(Posted: Feb-01-2023 6AM)
Influence of social deprivation index on in-hospital outcomes of COVID-19.
Parag Goyal et al. Scientific reports 2023 1 (1) 1746
(Posted: Feb-01-2023 6AM)
Could Africa be the future for genomics research?
Z Lombard et al, Nature, January 31, 2023
(Posted: Jan-31-2023 8AM)
Machine learning models for predicting severe COVID-19 outcomes in hospitals
P Wendland et al, MEDRXIV, January 30, 2023
(Posted: Jan-31-2023 8AM)
A large-scale machine learning study of sociodemographic factors contributing to COVID-19 severity
M Tumbas et al, MEDRXIV, January 29, 2023
(Posted: Jan-30-2023 7AM)
Genomic surveillance of SARS-CoV-2 in COVID-19 vaccinated healthcare workers in Lebanon.
Habib AlKalamouni et al. BMC medical genomics 2023 1 (1) 14
(Posted: Jan-30-2023 6AM)
Agent-based modeling and phylogenetic analysis suggests that COVID-19 will remain a low-severity albeit highly transmissible disease
JCT Roy et al, MEDRXIV, January 28, 2023
(Posted: Jan-29-2023 7AM)
Should COVID vaccines be yearly? Proposal divides US scientists
M Kozlov, Nature, January 27, 2023
(Posted: Jan-27-2023 9AM)
The impact of COVID-19 lockdown on a cohort of adults with recurrent major depressive disorder from Catalonia: a decentralized longitudinal study using remote measurement technology
R Lavalle et al, MEDRXIV, January 27, 2023
(Posted: Jan-27-2023 7AM)
Do bivalent boosters work against XBB.1.5? Vaccine questions, answered. New CDC data shows updated boosters are cutting risk of getting sick from covid-19 by about half
N Nerapil et al, Washington Post, January 25, 2023
(Posted: Jan-27-2023 7AM)
A Randomized Trial Comparing Omicron-Containing Boosters with the Original Covid-19 Vaccine mRNA-1273
IT Lee et al, MEDRXIV, January 24, 2023
(Posted: Jan-26-2023 7AM)
Wastewater and surface monitoring to detect COVID-19 in elementary school settings: The Safer at School Early Alert project
RKF Miller et al, MEDRXIV, January 25, 2023
(Posted: Jan-26-2023 7AM)
COVision: Convolutional Neural Network for the Differentiation of COVID-19 from Common Pulmonary Conditions using CT Scans
K Parikh et al, MEDRXIV< January 23, 2023
(Posted: Jan-24-2023 7AM)
Wastewater-based surveillance can be used to model COVID-19-associated workforce absenteeism
N Acosta et al, MEDRXIV< January 23, 2023
(Posted: Jan-24-2023 7AM)
Evaluation of Potential Adverse Events Following COVID-19 mRNA Vaccination Among Adults Aged 65 Years and Older: A Self-Controlled Study in the U.S.
A Shaobi et al, MEDRIV, January 23, 2023
(Posted: Jan-23-2023 9AM)
Immunogenicity, Safety and Effectiveness of COVID-19 Pfizer-BioNTech (BNT162b2) mRNA Vaccination in Immunocompromised Adolescents and Young Adults: A systematic Review and Meta-Analyses
P Katoto et al, MEDRXIV, January 20, 2023
(Posted: Jan-22-2023 8AM)
The fourth dose of mRNA COVID-19 vaccine following 12 different three-dose regimens: Safety and immunogenicity to Omicron BA.4/BA.5
S Kanokudom et al, MEDRXIV, January 19, 2023
(Posted: Jan-20-2023 6AM)
Real-world COVID-19 vaccine effectiveness against the Omicron BA.2 variant in a SARS-CoV-2 infection-naive population
JJ Lau et al, Nature Medicine, January 18, 2023
(Posted: Jan-18-2023 1PM)
Development of an amplicon-based sequencing approach in response to the global emergence of human monkeypox virus
NFG Chen et al, MEDRXIV, January 13, 2023
(Posted: Jan-16-2023 7AM)
CDC & FDA Identify Preliminary COVID-19 Vaccine Safety Signal for Persons Aged 65 Years and Older
CDC, January 13, 2023
(Posted: Jan-16-2023 6AM)
Variations in COVID-19 impacts by social vulnerability in Philadelphia, June 2020-December 2022
KM Strelau et al, MEDRXIV< January 14, 2023
(Posted: Jan-16-2023 5AM)
Cross-sectional Ct distributions from qPCR tests can provide an early warning signal for the spread of COVID-19 in communities
M Sharmin et al, MEDRXIV, January 14, 2023
(Posted: Jan-16-2023 5AM)
Coronavirus variant XBB.1.5 rises in the United States - is it a global threat?
Callaway Ewen et al. Nature 2023 1 (7943) 222-223
(Posted: Jan-11-2023 6AM)
The coronavirus is speaking. It’s saying it’s not done with us.
E Topol, Washington Post, January 8, 2023
(Posted: Jan-09-2023 6AM)
Comparative effectiveness of third doses of mRNA-based COVID-19 vaccines in US veterans
BA Dickerman et al, Nat Microbiology, January 22, 2023
(Posted: Jan-02-2023 0PM)
Moderna COVID-19 Vaccine Safe and Effective for Children 6 Months to 5 Years.
Slomski Anita et al. JAMA 2022 12 (24) 2388
(Posted: Jan-02-2023 9AM)
DIGItal Health Literacy after COVID-19 Outbreak among Frail and Non-Frail Cardiology Patients: The DIGI-COVID Study
M Vitolo et al, J Per Med, December 31, 2020
(Posted: Dec-31-2022 7AM)
Omicron Subvariant XBB Jumps to 18% of US COVID Cases: CDC
Medscape, December 27, 2022
(Posted: Dec-29-2022 11AM)
Multi-objective optimization identifies a specific and interpretable COVID-19 host response signature.
Cappuccio Antonio et al. Cell systems 2022 12 (12) 989-1001.e8
(Posted: Dec-26-2022 0PM)
The impact of pre-existing cross-reactive immunity on SARS-CoV-2 infection and vaccine responses.
Murray Sam M et al. Nature reviews. Immunology 2022 12 1-13
(Posted: Dec-25-2022 8AM)
Race, inequalities, and burden of COVID-19 in the USA
G Bisbas, The Lancet Infectious Diseases, December 21, 2022
(Posted: Dec-22-2022 9AM)
Evolution of long-term vaccine induced and hybrid immunity in healthcare workers after different COVID-19 vaccination regimens: a longitudinal observational cohort study
SC Moore et al, MEDRXIV, December 21, 2022
(Posted: Dec-22-2022 8AM)
Digital Omicron Detection using Unscripted Voice Samples from Social Media
J Anibal et al, MEDRXIV, December 22, 2022
(Posted: Dec-22-2022 8AM)
Cross-Clade Memory Immunity in Adults Following SARS-CoV-1 Infection in 2003.
Ng Rita W Y et al. JAMA network open 2022 12 (12) e2247723
(Posted: Dec-21-2022 1PM)
Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children
D Lee et al, Science, December 20, 2022
(Posted: Dec-20-2022 11AM)
Comparison of the mucosal and systemic antibody responses in Covid-19 recovered patients with one dose of mRNA vaccine and unexposed subjects with three doses of mRNA vaccines
S Liu et al, MEDRXIV, December 19, 2022
(Posted: Dec-20-2022 7AM)
Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Genomics and Precision Public Health to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
- Page last reviewed:Feb 1, 2023
- Page last updated:Mar 30, 2023
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