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Last Posted: May-14-2024 15:11:30

The State of State Biomarker Testing Insurance Coverage Laws
(Posted May 14, 2024 3PM)

From the article:" There has been a recent push for legislation mandating coverage of “biomarker testing” according to evidence that receipt of such testing can depend on race and ethnicity, age, geography, or site of care. A specific type of biomarker testing for cancer subtypes (ie, “tumor profiling”) is becoming particularly important because many newer cancer therapies target specific mutations (eg, EGFR in non–small cell lung cancer, KRAS in colorectal cancer). Although use of biomarker testing is increasing, barriers to access persist. Cost and lack of insurance coverage are common barriers to testing because insurance coverage varies across commercial payers, Medicare, and Medicaid."

High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response
(Posted May 14, 2024 3PM)

From the abstract: " How human genetic variation contributes to vaccine effectiveness in infants is unclear, and data are limited on these relationships in populations with African ancestries. We undertook genetic analyses of vaccine antibody responses in infants from Uganda (n=1391), Burkina Faso (n=353) and South Africa (n=755), identifying associations between human leukocyte antigen (HLA) and antibody response for five of eight tested antigens spanning pertussis, diphtheria and hepatitis B vaccines. In addition, through HLA typing 1,702 individuals from 11 populations of African ancestry derived predominantly from the 1000 Genomes Project, we constructed an imputation resource, fine-mapping class II HLA-DR and DQ associations explaining up to 10% of antibody response variance in our infant cohorts. "

Addressing Health Disparities—The Case for Variant Transthyretin Cardiac Amyloidosis Grows Stronger
(Posted May 14, 2024 3PM)

From the article: "There has been a transformational change in understanding heart failure due to transthyretin cardiac amyloidosis (ATTR-CA). Previously considered a rare condition, the widespread adaptation of nuclear imaging to establish the diagnosis has led to the recognition that ATTR-CA is commonly encountered in clinical practice. Additionally, the advent of effective disease-modifying therapies that reduce morbidity and mortality among affected patients has afforded hope to those newly diagnosed. Because these disease-modifying therapies are more effective when administered early in the course of the illness, before significant end-organ dysfunction has occurred, it is vital to facilitate early diagnosis. "

Public Attitudes, Interests, and Concerns Regarding Polygenic Embryo Screening
(Posted May 14, 2024 3PM)

From the paper: "Question: Among US adults, what are the general attitudes, interests, and concerns regarding polygenic embryo screening (PES)? Findings: In this survey study exploring public sentiment toward PES, there was high approval and interest among respondents despite high societal concerns. In a second sample, presenting concerns at survey onset (vs survey end) was associated with less public approval and more uncertainty but with only slightly higher disapproval. Meaning: With the recent commercial availability of unregulated PES, the combination of high approval and high concerns observed among respondents in this study suggests the need for informed dialogue and guidance, particularly in addressing the divide between the public and health care professionals. "

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Disclaimer: Articles listed in the Public Health Genomics and Precision Health Knowledge Base are selected by the CDC Public Health Genomics Branch to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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