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COVID-19 GPH|Home|PHGKB Last data update: Apr 22, 2021 . (Total: 14381 Documents since 2020)

Last Posted: Apr-22-2021 11:33:32
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Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19
REMAP CAP investigators, NEJM, April 21, 2021

In critically ill patients with Covid-19 receiving organ support in ICUs, treatment with the interleukin-6 receptor antagonists tocilizumab and sarilumab improved outcomes, including survival.

Vaccine Breakthrough Infections with SARS-CoV-2 Variants
E Hacisuleyman et al, NEJM, April 21, 2021

Emerging variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of clinical concern. In a cohort of 417 persons who had received the second dose of mRNA vaccine at least 2 weeks previously, we identified 2 women with vaccine breakthrough infection. Despite evidence of vaccine efficacy in both women, symptoms of coronavirus disease 2019 developed, and they tested positive for SARS-CoV-2 by polymerase-chain-reaction testing. Viral sequencing revealed variants of likely clinical importance, including E484K in 1 woman and three mutations (T95I, del142–144, and D614G) in both.

Postvaccination SARS-CoV-2 Infections Among Skilled Nursing Facility Residents and Staff Members — Chicago, Illinois, December 2020–March 2021
RA Teran et al, MMWR, April 21, 2021

Twenty-two possible breakthrough SARS-CoV-2 infections occurred among fully vaccinated persons =14 days after their second dose of COVID-19 vaccine. Two thirds of persons were asymptomatic. A minority of persons with breakthrough infection experienced mild to moderate COVID-19–like symptoms; two COVID-19–related hospitalizations and one death occurred. No facility-associated secondary transmission was identified.

COVID-19 Outbreak Associated with a SARS-CoV-2 R.1 Lineage Variant in a Skilled Nursing Facility After Vaccination Program — Kentucky, March 2021
AM Cavanaugh et al, MMWR, April 21, 2021

In a COVID-19 outbreak at a Kentucky skilled nursing facility involving a newly introduced variant to the region, unvaccinated residents and health care personnel (HCP) had 3.0 and 4.1 times the risk of infection as did vaccinated residents and HCP. Vaccine was 86.5% protective against symptomatic illness among residents and 87.1% protective among HCP.

news Latest News and Publications
Mechanical transmission of SARS-CoV-2 by house flies.
Balaraman Velmurugan et al. Parasites & vectors 2021 4 (1) 214

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Phylogenetic estimates of SARS-CoV-2 introductions into Washington State.
Tordoff Diana M et al. medRxiv : the preprint server for health sciences 2021 4

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Sentinel cells enable genetic detection of SARS-CoV-2 Spike protein
ZY Weinberg et al, BIORXIV, April 20, 2021

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Effectiveness of the BNT162b2 vaccine in preventing COVID-19 in the working age population - first results from a cohort study in Southern Sweden
J Bjork et al, MEDRXIV, April 21, 2021

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Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 isolates from Pennsylvania
AM Moustafa et al, BIORXIV, April 21, 2021

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Discrete immune response signature to SARS-CoV-2 mRNA vaccination versus infection
EN Ivanova et al, MEDRXIV, April 21, 2021

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Data mining of coronavirus: SARS-CoV-2, SARS-CoV and MERS-CoV.
Huh Jung Eun et al. BMC research notes 2021 4 (1) 150

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High prevalence of SARS-CoV-2 B.1.1.7 (UK variant) and the novel B. lineage in Oyo State, Nigeria.
Ozer Egon A et al. medRxiv : the preprint server for health sciences 2021 4

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Single-cell multi-omics analysis of the immune response in COVID-19.
Stephenson Emily et al. Nature medicine 2021 4

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Artificial intelligence (AI) for medical imaging to combat coronavirus disease (COVID-19): a detailed review with direction for future research.
Soomro Toufique A, et al. Artificial intelligence review 2021 0 0. 1-31

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About COVID-19 GPH

COVID-19 GPH is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other materials that captures emerging discoveries and applications of genomics, molecular and other precision medicine and precision public health tools in the investigation and control of COVID-19. Contents include PubMed records via an automated pubmed search algorithm, preprint records from NIH iCite, the relevant information from many media sources picked by experts, and linkages to contents from our curated PHGKB databases.

Genomics Precision Health (GPH): The use of pathogen and human genomics and advanced molecular detection methods in discovery, clinical and public health investigations involving COVID-19.
Non Genomics Precision Health (non-GPH): The use of big data, data science and machine learning methods (not involving genomics) in discovery, clinical and public health investigations involving COVID-19

Following categories are annotated by LitCovid from NCBI NIH.
MechanismUnderlying cause(s) of covid-19 infections and transmission & possible drug mechanism of action
Transmission Characteristics and modes of covid-19 transmissions, such as human-to-human
DiagnosisDisease assessment through symptoms, test results, and radiological features
PreventionPrevention, control, response and management strategies
Case ReportDescriptions of specific patient cases
ForecastingModelling and estimating the trend of covid-19 spread

Following categories are annotated by the text mining tool from CDC PHGKB
Health EquityRelevant to health equity. Search terms are derived from a list provided by the Association for Territorial Health Officials which include terms such as diversity, health disparities, and others.
VaccineRelevant to vaccine development, evaluation, implementation and impact. For additional information on vaccines and COVID-19. Check out general CDC Information pages
VariantRelevant to SARS-CoV-2 variants and their impact on public health. For additional information on variants COVID-19. Check out CDC New Variants of the Virus that Causes COVID-19 page
SurveillanceRelevant to SARS-CoV-2 public health surveillance and tracking. For additional information on COVID-19 surveillance, check out CDC COVID-19 Data Tracker

Disclaimer: Articles listed in the Public Health Genomics and Precision Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.