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Hot Topics of the Day|PHGKB
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01/16/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Nearly 10,000 NorthShore patients have taken DNA tests to check for health risks. Now, that program is expanding.
L Schenker, Chicago Tribune, January 14, 2020

Though a number of hospital systems perform genetic testing on certain patients, such as those with cancer, the idea of offering broad testing as a part of routine primary care is still relatively new. A handful of hospital systems across the country that have seized on the idea.

Online Information on Probiotics: Does It Match Scientific Evidence?
M Neunez et al, Frontiers in Medicine, January 15, 2020

This study highlights important biases in the probiotics information available online, underlining the need to improve the quality and objectivity of information provided to the public.

Suicide.
Fazel Seena et al. The New England journal of medicine 2020 Jan (3) 266-274

Throughout the world, approximately 800,000 people die by suicide every year. Risk factors for suicide include family history, genetic and epigenetic factors.

A healthy childhood environment helps to combat inherited susceptibility to obesity
A Huels et al, BioRXIV, January 14, 2020

Cohort study with measurements of diet, lifestyle factors and anthropometry. Polygenic risk scores captured the inherited susceptibility of obesity were calculated using summary statistics from independent genome-wide association studies of BMI. We observed significant interactions with demographic and lifestyle factors for BMI as well as waist circumference.

Ten Recommendations for Supporting Open Pathogen Genomic Analysis in Public Health Settings
A Black et al, preprints, January 2020

The wide adoption of pathogen genomics poses challenges due to the amount of data generated and the need to transform raw data prior to analysis. This complexity means that public health agencies may need more advanced computational infrastructure, a broader technical workforce, and new approaches to data management and stewardship.

New predictors for immunotherapy responses sharpen our view of the tumour microenvironment
TS Bruno, Nature News, January 15, 2020

Three studies reveal that the presence in tumors of two key immune components — B cells and tertiary lymphoid structures — is associated with favorable outcomes when individuals undergo immunotherapy

Evidence for penetrance in patients without a family history of disease: a systematic review.
Turner Heather et al. European journal of human genetics : EJHG 2020 Jan

It is evident from the findings that the evidence base for penetrance estimates in individuals without a family history of disease is limited. Future work is needed to refine design of penetrance studies and the impact of incorrect estimates.

A new comprehensive colorectal cancer risk prediction model incorporating family history, personal characteristics, and environmental factors.
Zheng Yingye et al. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2020 Jan

A familial risk profile (FRP) was calculated to summarize individuals' risk based on detailed cancer family history, family structure, probabilities of mutation in major CRC susceptibility genes, and a polygenic component.Our findings suggested detailed family history may be useful for targeted risk-based screening and clinical management

BRCA Research Update: Looking Back At 2019 And Plans For The Future
S Domcheck Besser Center webinar, February 20, 2020

Susan Domchek, MD, will present a webinar on recent advancements in BRCA-related research. For this annual webinar, she discusses recent clinical trials and scientific advancements, and breakthroughs in cancer treatment such as current FDA approvals.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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