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Hot Topics of the Day|PHGKB
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10/19/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

COVID-19, Social Justice, and Clinical Cancer Research
JH Doroshow et al, JNCI, October 15, 2020

Entering the era of precision medicine in pediatric oncology
D Hadjdadj et al, Nature Medicine, October 19, 2020

The Zero Childhood Cancer Program’s multi-platform sequencing approach identified molecular alterations in 94% of a cohort of 247 pediatric patients with high-risk cancers, which has enabled more-precise diagnoses and alternative therapeutic recommendations.

Discovery and validation of a personalized risk predictor for incident tuberculosis in low transmission settings
RK Gupta et al, Nature Medicine, October 19, 2020

We developed a personalized risk predictor for incident TB that combines a quantitative measure of T cell sensitization and clinical covariates. Internal–external cross-validation of the model demonstrated a random effects meta-analysis C-statistic of 0.88 (95% CI, 0.82–0.93) for incident TB. In decision curve analysis, the model demonstrated clinical utility for targeting preventative treatment, compared to treating all, or no, people with LTBI.

Suicide Prevention in the COVID-19 Era- Transforming Threat Into Opportunity
C Moutier, JAMA Psychiatry, October 16, 2020

COVID-19 presents a new and urgent opportunity to focus political will, federal investments, and global community on the vital imperative of suicide prevention. Suicide prevention in the COVID-19 era requires addressing not only pandemic-specific suicide risk factors, but also prepandemic risk factors. This paper provides prioritized, evidence-based strategies along with national and local policy and educational initiatives tailored to the COVID-19 environment.

COVID-19 and Psychological Distress-Changes in Internet Searches for Mental Health Issues in New York During the Pandemic.
Stijelja Stefan et al. JAMA internal medicine 2020 Oct

Searches for anxiety, panic attack, and insomnia rose significantly during the lockdown, then eventually reverted to their mean. Assuming this is indicative of significant increases in these symptoms, this suggests the need to provide focused competent online and telemedicine services during quarantines.

Individuals with Down syndrome hospitalized with COVID-19 have more severe disease
L Malle et al, Genetics in Medicine, October 18, 2020

In this retrospective study of 7246 patients hospitalized with COVID-19, we identified 12 patients with DS. Hospitalized individuals with DS are on average ten years younger than patients without DS. Patients with DS have more severe disease than controls, particularly an increased incidence of sepsis and mechanical ventilation.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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