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Last Posted: Nov 23, 2022
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Making cough count in tuberculosis care
AJ Zimmer et al, Comm Medicine, July 6, 2022

Acoustic epidemiology is an emerging field that uses technology to detect cough sounds and analyze cough patterns to improve health outcomes among people with respiratory conditions linked to cough. This field is increasingly exploring the potential of artificial intelligence (AI) for more advanced applications, such as analyzing cough sounds as a biomarker for disease screening. While much of the data are preliminary, objective cough assessment could potentially transform disease control programs, including TB, and support individual patient management.

Using Pharmacogenetics to Enhance Tuberculosis (TB) Treatment
M Moore et al, CDC Blog Post, February 22, 2022 Brand

A new CDC project provides an unprecedented opportunity to develop a tailored approach, by leveraging existing information collected in the international phase 3 clinical trial, to identify specific dosage recommendations of TB drugs for populations, which can improve TB treatment across all patient groups. Researchers will utilize precision public health techniques to assess treatment outcomes for TB treatment regimens, which may lead to improvements in the prevention and treatment of TB disease.

Precision Public Health in Action: New CDC Pilot Projects Integrating Human Genomics into Public Health Surveillance and Applied Research
M Clyne et al, CDC Blog Post, February 14, 2022 Brand

Six CDC projects were selected for funding in 2022 and 2023. They cover a wide range of topics, including: Assessing the impact of genetics in the control of two infectious diseases (Tuberculosis and Ebola), enhancing the reporting of gene/genome sequencing in newborn screening programs, examining the role of medications and genetics in the National Birth Defects Prevention Study (NBDPS), establishing population-based, ethnicity-specific allele frequencies for pharmacogenomic traits of public health importance using the National Health and Nutrition Examination Survey (NHANES), and enhancing the evaluation of genetic risk prediction models for inhibitor development among people with hemophilia in different populations.

Using Genomic Epidemiology to Advance Public Health Action
CDC Preventive Medicine Grand Rounds, February 22, 2022 Brand

Rapid advances in genomic technologies, such as genomic sequencing, are transforming how we respond to public health threats. Scientists use genomic sequencing to identify and prevent a wide variety of pathogens, including those that cause foodborne illness, tuberculosis, and COVID-19. Combining genomics and epidemiology—coined “genomic epidemiology”—provides a powerful tool for surveillance, outbreak detection, as well as response, and indicates a future where the human genome can direct public health action.

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Disclaimer: Articles listed in the Public Health Genomics and Precision Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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