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Last Posted: Mar 14, 2023
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A new class of antibiotics delivers promising trial results against tuberculosis.
Carvalho Thiago et al. Nature medicine 2022 11

Nature Medicine explores the latest translational and clinical research news, with a clinical trial of a tRNA synthetase inhibitor for tuberculosis. The molecule functions as an inhibitor of the Mycobacterium tuberculosis enzyme leucyl-tRNA synthetase, blocking protein synthesis. Patients with drug-susceptible pulmonary tuberculosis treated with the investigational drug for 14 days showed a significant, dose-dependent reduction in colony-forming units in their sputum, the trial’s primary endpoint.

The science events to watch for in 2023 Moon landings, mRNA vaccines and climate finance are among the developments set to shape research in the coming year.
M Naddaf et al, Nature, December 19, 2022

Following the successful deployment of mRNA vaccines during the COVID-19 pandemic, a host of them are in development. BioNTech in Mainz, Germany, is expected to initiate first-in-human trials for mRNA vaccines against malaria, tuberculosis and genital herpes in the coming weeks. BioNTech is also collaborating with Pfizer, based in New York City, to trial an mRNA-based vaccine candidate to reduce the rate of shingles. Moderna in Cambridge, Massachusetts, also has mRNA vaccine candidates for the viruses that cause genital herpes and shingles.

Making cough count in tuberculosis care
AJ Zimmer et al, Comm Medicine, July 6, 2022

Acoustic epidemiology is an emerging field that uses technology to detect cough sounds and analyze cough patterns to improve health outcomes among people with respiratory conditions linked to cough. This field is increasingly exploring the potential of artificial intelligence (AI) for more advanced applications, such as analyzing cough sounds as a biomarker for disease screening. While much of the data are preliminary, objective cough assessment could potentially transform disease control programs, including TB, and support individual patient management.

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Disclaimer: Articles listed in the Public Health Genomics and Precision Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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