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Last Posted: Nov 14, 2023
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An AI-Enhanced Electronic Health Record Could Boost Primary Care Productivity.
Jeffrey E Harris et al. JAMA 2023 8

More than a few commentators have seriously inquired whether artificial intelligence (AI) could ultimately replace many clinicians. The far likelier prospect, however, is that the newly emerging technology will enhance clinical productivity. To be sure, AI-based pattern recognition software can already scan retinal photos for complications of diabetes, detect tuberculosis on chest x-rays, and evaluate screening mammograms. And some AI applications have been found to be comparable if not superior to human clinical judgment.

A new class of antibiotics delivers promising trial results against tuberculosis.
Carvalho Thiago et al. Nature medicine 2022 11

Nature Medicine explores the latest translational and clinical research news, with a clinical trial of a tRNA synthetase inhibitor for tuberculosis. The molecule functions as an inhibitor of the Mycobacterium tuberculosis enzyme leucyl-tRNA synthetase, blocking protein synthesis. Patients with drug-susceptible pulmonary tuberculosis treated with the investigational drug for 14 days showed a significant, dose-dependent reduction in colony-forming units in their sputum, the trial’s primary endpoint.

The science events to watch for in 2023 Moon landings, mRNA vaccines and climate finance are among the developments set to shape research in the coming year.
M Naddaf et al, Nature, December 19, 2022

Following the successful deployment of mRNA vaccines during the COVID-19 pandemic, a host of them are in development. BioNTech in Mainz, Germany, is expected to initiate first-in-human trials for mRNA vaccines against malaria, tuberculosis and genital herpes in the coming weeks. BioNTech is also collaborating with Pfizer, based in New York City, to trial an mRNA-based vaccine candidate to reduce the rate of shingles. Moderna in Cambridge, Massachusetts, also has mRNA vaccine candidates for the viruses that cause genital herpes and shingles.

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