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Hot Topics of the Day|PHGKB
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04/15/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

NIMHD Transdisciplinary Collaborative Centers for Health Disparities Research Focused on Precision Medicine.
Rajapakse Nishadi et al. Ethnicity & disease 2020 30(Suppl 1) 135-136

Financial barriers in a county genetics clinic: Problems and solutions.
Erwin Deanna J et al. Journal of genetic counseling 2020 Apr

Precision Medicine Approaches to Health Disparities Research.
Griffith Derek M et al. Ethnicity & disease 2020 30(Suppl 1) 129-134

Machine Learning Methods for Precision Medicine Research Designed to Reduce Health Disparities: A Structured Tutorial.
Basu Sanjay et al. Ethnicity & disease 2020 30(Suppl 1) 217-228

We provide a structured tutorial for medical and public health researchers on the application of machine learning methods to conduct precision medicine research designed to reduce health disparities. We review key terms and concepts including supervised and unsupervised learning, regularization, cross-validation, bagging, and boosting.

Germline Testing for Patients With BRCA1/2 Mutations on Somatic Tumor Testing.
Vlessis Katherine et al. JNCI cancer spectrum 2020 Feb 4(1) pkz095

UK Biobank: DNA to unlock coronavirus secrets
R Morelle, BBC News, April 14, 2020

UK Biobank makes infection and health data available to tackle COVID-19
UK Biobank, April 14, 2020

Results of COVID-19 tests for UK Biobank participants will be available for research. This will allow the study of the relevance of various genetic and non-genetic factors to severity and outcome to be assessed in different age groups and provide analysis of the prevalence, course and death rate, as well as impact of different diseases and comorbidities.

How Do We Exit The Shutdown? Hire An Army Of Public Health Workers
AM Barry-Jester, KHN News, April 13, 2020

In N.Y.C., the Coronavirus Is Killing Men at Twice the Rate of Women- More men also are infected than women, and they are hospitalized more frequently, new data show. A similar pattern was seen in China.
RC Rabin, NY Times, April 2020

Antibody Points to Possible Weak Spot on Novel Coronavirus
F Collins, Director's blog, April 14, 2020 Brand

Spread of SARS-CoV-2 in the Icelandic Population
DF. Gudbjartsson et al, NEJM, April 14, 2020

we used two strategies for SARS-CoV-2 testing— targeted testing of persons at high risk and population screening — which provided a gauge of success of measures implemented. We also sequenced the genomes of SARS-CoV-2 from samples obtained from some persons who had tested positive to establish virus origins and to determine how the virus has mutated as it has spread

Caution Warranted: Using the Institute for Health Metrics and Evaluation Model for Predicting the Course of the COVID-19 Pandemic
NP Jewell et al, Ann Int Med, April 14, 2020

Coronavirus Tests Science’s Need for Speed Limits- Preprint servers and peer-reviewed journals are seeing surging audiences, with many new readers not well versed in the limitations of the latest research findings
W Yan, NY Times, April 14, 2020


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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