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Hot Topics of the Day|PHGKB
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02/27/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Positive RT-PCR Test Results in Patients Recovered From COVID-19
L Lan et al, JAMA, February 27, 2020

Four patients with COVID-19 who met criteria for hospital discharge or discontinuation of quarantine in China (absence of clinical symptoms and radiological abnormalities and 2 negative RT-PCR test results) had positive RT-PCR test results 5 to 13 days later. These findings suggest that at least a proportion of recovered patients still may be virus carriers.

Coronavirus vaccines are far off, FDA official says, but drugs to treat patients could come sooner
M Herper, StatNews, February 26, 2020

Escaping Pandora's Box - Another Novel Coronavirus.
Morens David M et al. The New England journal of medicine 2020 Feb

Genetic diversity and evolution of SARS-CoV-2.
Phan Tung et al. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2020 Feb 104260

Leveraging the health information technology infrastructure to advance federal research priorities.
Zayas-Cabán Teresa et al. Journal of the American Medical Informatics Association : JAMIA 2020 Feb

Use of health information technology (IT) by U.S. healthcare providers and patient access to electronic health data have increased significantly in the past decade.1–5 This has been facilitated by technological changes in information system capabilities and infrastructure,6–9 as well as legislation, governmental programs, and policies.

A Group-Mediated Approach to Precision Medicine-Social Identification, Prevention, and Treatment.
Beauchamp Mark R et al. JAMA psychiatry 2020 Feb

Precision medicine mostly focuses on genomics. There is emerging interest to screen for social risk factors in clinical settings, such as unemployment, food insecurity, partner violence, housing quality, and difficulty affording medication.

Association of Leukocyte Telomere Length With Mortality Among Adult Participants in 3 Longitudinal Studies
KG Arbeev et al, JAMA Network Open, February 26, 2020t

This cohort study included 3259 participants from 3 longitudinal studies, of whom 1525 died during the follow-up period. Leukocyte telomere length–associated mortality from noncancer causes increased as participants aged, approaching their age at death. These data suggest that leukocyte telomere length is associated with a life span limit among contemporary humans.

Evaluating the promise of inclusion of African ancestry populations in genomics
AR Bentley et al. NPJ Genomic Medicine, February 26, 2020

We evaluate the promise of including diverse individuals in genomic research in the context of recent literature on individuals of African ancestry. In addition, we discuss progress and achievements on related technological challenges and diversity among scientists conducting genomic research.

Down syndrome.
Antonarakis Stylianos E et al. Nature reviews. Disease primers 2020 Feb (1) 9

Since the first description of trisomy 21, we have learned much about intellectual disability and genetic risk factors for congenital heart disease. Clinical trials to ameliorate intellectual disability in DS signal a new era in which therapeutic interventions based on knowledge of the molecular pathophysiology of DS can now be explored.

MGI Delivers the $100 Genome at AGBT Conference
GEN News, February 27, 2020

The promise of a $100 genome, which has been tossed around for a while, is “a great achievement” Drmanac told GEN on the eve of his presentation. Because his personal goal is to sequence “as many genomes as possible,” it follows suit that they have to be affordable.

Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation.
Peled Jonathan U et al. The New England journal of medicine 2020 Feb (9) 822-834

Patterns of microbiota disruption during allogeneic hematopoietic-cell transplantation were similar across transplantation centers and geographic locations; patterns were characterized by loss of diversity and domination by single taxa. Higher diversity of intestinal microbiota at the time of neutrophil engraftment was associated with lower mortality.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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