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Hot Topics of the Day|PHGKB
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12/15/2019

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Biological age in UK Biobank: biomarker composition and prediction of mortality, coronary heart disease and hospital admissions
MS Chan et al, MedrxIV, December 15, 2019

This study identified that markers of impaired function in a range of organs account for a substantial proportion of the apparent effect of age on disease and hospital admissions. It supports a broader, multi-system approach to research and prevention of diseases of ageing

Genome-wide assessment of genetic risk for systemic lupus erythematosus and disease severity
L Chen, BioRXIV, December 13, 2019

A genetic risk score predicts SLE in both European and Chinese populations and correlates with poorer prognostic factors: young age of onset and lupus nephritis.

Clinical validity of expanded carrier screening: evaluating the gene-disease relationship in more than 200 conditions
M Balzotti et al, MedRXIV, December 15, 2019

We applied a standardized framework for evaluation of gene-disease association to assess the clinical validity of conditions screened by ECS panels. Methods: The ClinGen gene curation framework was used to assess genetic and experimental evidence of associations between 208 genes and conditions screened on two commercial ECS panels.

Molecular messages in human microbiota
MT Henke et a, Science, December 13, 2019

Two articles describe how bioinformatic analysis of metagenomes—the collective genes of a microbial community—can reveal previously unknown bacterial metabolites that may function as antibiotics; and a gene-deletion approach that discovered the ability of known bacterial metabolites to affect human immune responses.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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