Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content


Hot Topics of the Day|PHGKB
Search PHGKB:

12/10/2019

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

Sign up MyPHGKB to receive the daily hot topic email alert.

Search Archive:
Archived Hot Topics of the Day By Date

Genetic contribution to lipid target achievement with statin therapy: a prospective study.
Ruiz-Iruela Cristina et al. The pharmacogenomics journal 2019 Dec

Statin therapy response is highly variable. Variants of lipid metabolism genes and statin pharmacokinetic modulators could play a role, however, the impact of most of these variants remains unconfirmed. A prospective and multicenter study included 252 patients was carried out in order to assess the impact of gene variants on statin response.

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases
J Zheng et al, BIORXIV, December 2019

The human proteome is a major source of therapeutic targets. Recent genetic association analyses of the plasma proteome enable systematic evaluation of the causal consequences of variation in plasma protein levels. Here, we estimated the effects of 1002 proteins on 225 phenotypes using two-sample Mendelian randomization.

Active Immunotherapy to Prevent Alzheimer Disease—A DNA Amyloid β 1-42 Trimer Vaccine
RN Rosenberg et al, JAMA Neurology, December 9, 2019

Preventing Alzheimer's disease: Can the DNA Aß42 trimer vaccine produce a noninflammatory immune response, and reduce the Aß42 peptide and tau neuropathologies in patients with early Alzheimer's disease.

How Twitter is changing medical research
N Wetsman, Nature Medicine, December 9, 2019

From online journal clubs to ‘tweetorials’ to conference updates, social media is changing the dissemination and discussion of biomedicine.

High-resolution micro-epidemiology of parasite spatial and temporal dynamics in a high malaria transmission setting in Kenya
CS Nelson et al, Nature Communications, December 9, 2019

Novel interventions that leverage the heterogeneity of parasite transmission are needed to achieve malaria elimination. To better understand spatial and temporal dynamics of transmission, we applied amplicon next-generation sequencing of two polymorphic gene regions to a cohort identified in a high-transmission setting in western Kenya.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
TOP