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Last Posted: Sep 30, 2022
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From Genomics to Proteomics— What’s the Impact on Population Health?
D Rasooly et al, CDC Blog Post, September 30, 2022 Brand

New insights into the genome have led to the emergence of proteomics, the study of the structure and function of an individual’s entire set of expressed proteins. Proteomics is highly linked to genomics, since the blueprint for each protein is inscribed on an organism’s genes. This field of study has great potential for advancing health and medicine.

After the Genome—A Brief History of Proteomics
M Suran, JAMA, August 31, 2022

With researchers touting recent success in sequencing the human genome’s remaining gaps, an emerging frontier is proteomics: identifying and studying an entire set of expressed proteins in the human body and other organisms. Collectively, these sets are called proteomes, and unlike genomes, proteomes alter over time and depict current health conditions—not conditions at risk of occurring.

Neutrophil proteomics identifies temporal changes and hallmarks of delayed recovery in COVID19
MB Long et al, MEDRXIV, August 22, 2022

Neutrophil changes associated with COVID19 disease severity and prolonged illness were characterized and candidate targets for modulation of neutrophil function were identified. Delayed recovery from COVID19 was associated with changes in metabolic and signalling proteins, complement, chemokine and leukotriene receptors, integrins and inhibitory receptors.

ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19
M Pietzner et al, Nat Comms, August 15, 2022

Despite two years of intense global research activity, host genetic factors that predispose to a poorer prognosis of COVID-19 infection remain poorly understood. Here, we prioritise eight robust (e.g., ELF5) or suggestive but unreported (e.g., RAB2A) candidate protein mediators of COVID-19 outcomes by integrating results from the COVID-19 Host Genetics Initiative with population-based plasma proteomics using statistical colocalisation.

Disclaimer: Articles listed in the Public Health Genomics and Precision Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.