From Genomics to Proteomics— What’s the Impact on Population Health?
D Rasooly et al, CDC Blog Post, September 30, 2022
New insights into the genome have led to the emergence of proteomics, the study of the structure and function of an individual’s entire set of expressed proteins. Proteomics is highly linked to genomics, since the blueprint for each protein is inscribed on an organism’s genes. This field of study has great potential for advancing health and medicine.
After the Genome—A Brief History of Proteomics
M Suran, JAMA, August 31, 2022
With researchers touting recent success in sequencing the human genome’s remaining gaps, an emerging frontier is proteomics: identifying and studying an entire set of expressed proteins in the human body and other organisms. Collectively, these sets are called proteomes, and unlike genomes, proteomes alter over time and depict current health conditions—not conditions at risk of occurring.
Neutrophil proteomics identifies temporal changes and hallmarks of delayed recovery in COVID19
MB Long et al, MEDRXIV, August 22, 2022
Neutrophil changes associated with COVID19 disease severity and prolonged illness were characterized and candidate targets for modulation of neutrophil function were identified. Delayed recovery from COVID19 was associated with changes in metabolic and signalling proteins, complement, chemokine and leukotriene receptors, integrins and inhibitory receptors.
ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19
M Pietzner et al, Nat Comms, August 15, 2022
Despite two years of intense global research activity, host genetic factors that predispose to a poorer prognosis of COVID-19 infection remain poorly understood. Here, we prioritise eight robust (e.g., ELF5) or suggestive but unreported (e.g., RAB2A) candidate protein mediators of COVID-19 outcomes by integrating results from the COVID-19 Host Genetics Initiative with population-based plasma proteomics using statistical colocalisation.