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Hot Topics of the Day|PHGKB
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11/16/2019

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

CRISPR's unwanted anniversary
J Doudna, Science, November 15, 2019

"It is encouraging that scientists around the globe responded by opening a deeper public conversation about how to establish stronger safeguards and build a viable path toward transparency and responsible use of CRISPR technology."

Translating translation in Down syndrome
M Halliday et al, Science, November 2019

Microbes and genes in heart failure
S Epelman, Science Magazine, November 2019

A new study shows that a confluence of factors—including genetic predisposition, production of a commensal gut microbial autoantigen, and systemic inflammation—together trigger the generation of autoreactive CD4+ T cells that cause autoimmune myocarditis and cardiac dysfunction in animals and patients.

Estimated Life Expectancy and Income of Patients With Sickle Cell Disease Compared With Those Without Sickle Cell Disease
D Lubeck et al, JAMA Network Open, November 15, 2019

This cohort simulation modeling study showed that projected life expectancy (54 vs 76 years) and quality-adjusted life expectancy (33 vs 67 years) were lower in the sickle cell disease cohort relative to the non–sickle cell disease cohort. Projected lifetime income was also lower in individuals with sickle cell disease.

Causal relationships between obesity and the leading causes of death in women and men.
Censin Jenny C et al. PLoS genetics 2019 Oct (10) e1008405

Using mendelian randomization, obesity traits were found to be causally involved in the majority of the leading causes of death, and some obesity traits affect disease risk differently in men and women. This has potential implications for public health strategies and indicates that sex-specific preventative measures may be needed.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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