Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content


Hot Topics of the Day|PHGKB
Search PHGKB:

09/09/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

Sign up MyPHGKB to receive the daily hot topic email alert.

Search Archive:
Archived Hot Topics of the Day By Date

Regardless of Age, Obesity and Hypertension Increase Risks With COVID-19
MH Katz, JAMA Internal Medicine, September 9, 2020

Obesity and Hypertension in the Time of COVID-19
G Rodgers et al, JAMA September 9, 2020

The confluence of disturbing trends in obesity, hypertension, and COVID-19 within communities of color appears to reflect a complex interplay of contributing factors that are rooted in the social determinants of health and structural racism.

Frequency and accuracy of proactive testing for COVID-19
T Bergstrom et al, MedRXIV, September 8, 2020

Genomic analysis reveals local transmission of SARS-CoV-2 in early pandemic phase in Peru
CP Rojas et al, BIORXIV, September 7, 2020

Mutational Analysis of SARS-CoV-2 Genome in African Population
OE Omotoso et al, BIORXIV, September 7, 2020

MOLECULAR EPIDEMIOLOGY TO UNDERSTAND THE SARS-CoV-2 EMERGENCE IN THE BRAZILIAN AMAZON REGION
MC De Santos et al, MEDRXIV, September 7, 2020

Ethnicity and clinical outcomes in COVID-19 A Systematic Review and Meta-analysis
S Sze et al, MEDRXIV, September 8, 2020

In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age.
Lieberman Nicole A P et al. PLoS biology 2020 Sep (9) e3000849

We examined host response gene expression across infection status, viral load, age, and sex among shotgun RNA sequencing profiles of nasopharyngeal (NP) swabs from 430 individuals with PCR-confirmed SARS-CoV-2 and 54 negative controls. Our data demonstrate that host responses are dependent on viral load with effects of age and sex that contribute to disease severity.

Clinical research underlies ethical integration of healthcare artificial intelligence
MD McCradden et al, Nature Medicine, September 9, 2020

Despite the promise of machine learning (ML), only a small fraction of developed models are successfully implemented at the point of care, a phenomenon called the ‘AI chasm’1. Crossing this chasm requires careful consideration of the most appropriate method of evaluation and oversight.

Reporting guidelines for clinical trial reports for interventions involving artificial intelligence: the CONSORT-AI extension
X Liu et al, Nature Medicine, September 9, 2020

The CONSORT-AI (Consolidated Standards of Reporting Trials–Artificial Intelligence) extension is a new reporting guideline for clinical trials evaluating interventions with an AI component. Guidelines were developed through a staged consensus process involving literature review and expert consultation to generate 29 candidate items.

Guiding better design and reporting of AI-intervention trials
Lancet Digital Health, September 9, 2020

AI is reshaping the global landscape of medicine. But evaluation of these AI interventions can be poorly reported, omitting vital information such as sample size calculations and how missing data were handled. To demonstrate their clinical efficacy, AI interventions must be assessed by randomized trials and findings accurately disseminated.

Association of mismatch repair status with survival and response to neoadjuvant chemo(radio)therapy in rectal cancer
SB Ye, NPJ Precision Oncology, September 8, 2020

Prior reports have indicated that defective mismatch repair (MMR) has a favorable impact on outcome in colorectal cancer patients treated with surgery, immunotherapy, or adjuvant chemotherapy. Here we report that dMMR was associated with improved disease-free survival (DFS) (P?=?0.034) in patients receiving neoadjuvant chemotherapy (NCT).

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases.
Zheng Jie et al. Nature genetics 2020 Sep

The human proteome is a major source of therapeutic targets. Recent genetic association analyses of the plasma proteome enable systematic evaluation of the causal consequences of variation in plasma protein levels. Here we estimated the effects of 1,002 proteins on 225 phenotypes using two-sample Mendelian randomization (MR) and colocalization.

The landscape of host genetic factors involved in immune response to common viral infections
L Kachuri et al, MEDRXIV, September 8, 2020

We conducted a genome-wide and transcriptome-wide association analyses to identify genetic loci associated with immunoglobulin G antibody response to 28 antigens for 16 viruses using serological data from 7924 European ancestry participants in the UK Biobank. The study confirms the importance of the HLA region in host response to viral infection and elucidates novel genetic determinants beyond HLA.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
TOP