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Hot Topics of the Day|PHGKB
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08/27/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Bridging digital health divides
A Agrawal, Science, August 28, 2020

The COVID-19 pandemic has accelerated digital health implementation in India and elsewhere, such as this telemedicine hub in New Delhi, expanding the reach of health care.

Emerging Pandemic Diseases: How We Got to COVID-19.
Morens David M et al. Cell 2020 Aug

Disease emergence reflects dynamic balances and imbalances, within complex globally distributed ecosystems comprising humans, animals, pathogens, and the environment. Understanding these variables is a necessary step in controlling future devastating disease emergences.

A New Mathematical Model for Controlled Pandemics Like COVID-19 : AI Implemented Predictions
LD Jones et al ARXIV, AUgust 24, 2020

Machine Reasoning to Assess Pandemics Risks: Case of USS Theodore Roosevelt
K Lai et al, ARXIV, August 24, 2020

Data Mining Approach to Analyze Covid19 Dataset of Brazilian Patients
JE Chire Saire, ARXIV, August 26, 2020

DeepSOCIAL: Social Distancing Monitoring and Infection Risk Assessment in COVID-19 Pandemic
M Rezaei et al, ARXIV, August 26, 2020

Global and Local Mutations in Bangladeshi SARS-CoV-2 Genomes
MM Hasan et al, BIORXIV, August 26, 2020

https://www.medrxiv.org/content/10.1101/2020.08.24.20181008v1
F Volpato et al, MEDRXIV, August 26, 2020

Artificial intelligence in radiation oncology
E Huynh et al, Nature Rev Clin Oncol, August 25, 2020

We provide an overview of the radiation therapy workflow with discussion of the implications that AI is likely to have on each step. We describe challenges associated with the clinical development and implementation of AI platforms in radiation oncology and provide our perspective on how these platforms might change the roles of radiotherapy medical professionals.

Association of MUC16 Mutation With Response to Immune Checkpoint Inhibitors in Solid Tumors
L Zhang et al, JAMA Network Open, August 26, 2020

MUC16 mutation appears to be associated with reported genomic factors associated with response to and improved outcomes for ICI treatment in solid tumors. It may hold promise as a marker for guiding immunotherapeutic responsiveness.

A Randomized Trial of Closed-Loop Control in Children with Type 1 Diabetes.
Breton Marc D et al. The New England journal of medicine 2020 Aug (9) 836-845

Hidden in Plain Sight — Reconsidering the Use of Race Correction in Clinical Algorithms
DA Vyas et al, NEJM, August 27, 2020

Our understanding of race and human genetics has advanced considerably since 2003, yet these insights have not led to clear guidelines on the use of race in medicine. The result is ongoing conflict between the latest insights from population genetics and the clinical implementation of race.

Efficacy of Selpercatinib in RET -Altered Thyroid Cancers.
Wirth Lori J et al. The New England journal of medicine 2020 Aug (9) 825-835

We enrolled patients with RET-mutant medullary thyroid cancer with or without previous vandetanib or cabozantinib treatment, as well as those with previously treated RET fusion-positive thyroid cancer, in a phase 1-2 trial of selpercatinib. Results show durable efficacy with mainly low-grade toxic effects in patients.

Selpercatinib Aimed at RET -Altered Cancers.
Kurzrock Razelle et al. The New England journal of medicine 2020 Aug (9) 868-869

A remarkable increase has occurred in the number of highly targeted drugs that have efficacy in patients with advanced cancers that harbor specific genomic alterations.


Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Public Health Genomics to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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