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Hot Topics of the Day|PHGKB
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08/19/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

FDA Issues Emergency Use Authorization to Yale School of Public Health for SalivaDirect, Which Uses a New Method of Saliva Sample Processing
FDA, August 15, 2020

Immuno-informatics approach for multi-epitope vaccine designing against SARS-CoV-2
S Banerjee et al, BIORXIV, August 18, 2020

Transcriptomic profiling of human corona virus (HCoV)-229E -infected human cells and genomic mutational analysis of HCoV-229E and SARS-CoV-2
N Friedman et al, BIORXIV, August 17, 2020

Race Disparities in the COVID-19 Pandemic—Solutions Lie in Policy, Not Biology
LE Boulware, JAMA Network Open, AUgust 18, 2020

Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study
Be Young et al, The Lancet, August 17, 2020

Severe acute respiratory syndrome coronavirus 2 variants with a 382-nucleotide deletion (?382) in the open reading frame 8 (ORF8) region of the genome have been detected in Singapore and other countries. we found that the ?382 variant is associated with a milder infection. This could have implications for the development of treatments and vaccines.

2020 FH Global Summit
The FH Foundation, August 2020

The FH Global Summit is the only conference entirely devoted to the care and treatment of inherited cardiovascular disorders including familial hypercholesterolemia (FH) and high lipoprotein(a). Each year, this invitation only event brings together unique voices to inspire and advent change.

Fats in the blood linked to autism- Precision medicine offers insight into a particular form of the disorder.
Nature, August 13, 2020

By mining medical records and genome sequences, scientists have identified a form of autism that is characterized by unusual levels of fat molecules in the blood.

Could population genetic screening improve public health?
C Gallagher, Mayo Clinic Blog, August 2020

Studies have found predisposition genetic screening with a limited panel of genetic information to be cost effective in a population under the age of 45. However, a population health screening approach to genetic medicine requires scrutiny, given the potential for added costs, over interpretation of disease risk and ethical and social factors.

A digital biomarker of diabetes from smartphone-based vascular signals
R Avram et al, Nature Medicine, August 17, 2020

We developed a deep neural network to detect prevalent diabetes using smartphone-based photoplethysmography from an initial cohort of 53,870 individuals, which we then validated in a separate cohort of 7,806 individuals and a cohort of 181 prospectively enrolled individuals from three clinics.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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