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Hot Topics of the Day|PHGKB
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07/06/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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A New Generation of Fast Coronavirus Tests Is Coming
KJ Wu, NY Times, July 6, 2020

New technologies, like the gene-editing tool Crispr, can spot the virus in less than an hour. But it will likely be months before these tests hit clinics.

Rapid and Inexpensive Whole-Genome Sequencing of SARS-CoV-2 using 1200 bp Tiled Amplicons and Oxford Nanopore Rapid Barcoding
NE Freed et al, BIORXIV, July 5, 2020

Temporal detection and phylogenetic assessment of SARS-CoV-2 in municipal wastewater
A Nemudryi et al, MEDRXIV, July 5, 2020

An Automatic Computer-Based Method for Fast and Accurate Covid-19 Diagnosis
AAA Jim et al, MEDRXIV, July 5, 2020

SARS-CoV-2 Spike protein variant D614G increases infectivity and retains sensitivity to antibodies that target the receptor binding domain
L Yurkovetskiey et al, BIORXIV, July 4, 2020

Experts focus on ‘superspreaders’ to study virus transmission
PBS, July 5, 2020

Microbiome and health implications for ethnic minorities after enforced lifestyle changes
DM Keohane et al, Nature Medicine, July 6, 2020

Comparative metagenomics of gut microbiomes shows that Irish Travellers retain a microbiota similar to that of non-industrialized societies. Their microbiota is associated with non-dietary factors and is proportionately linked with risk of microbiome-related metabolic disease.

https://www.nature.com/articles/s41591-020-0951-z
K Schultebrauks et al, Nature Medicine, July 6, 2020

We develop and validate an algorithm for prediction of post-traumatic stress course over 12 months using two independently collected prospective cohorts of trauma survivors from two level 1 emergency trauma centers, using routinely collectible data from electronic medical records, along with brief clinical assessments of the patient’s immediate stress reaction.

Validation of the BOADICEA model and a 313-variant polygenic risk score for breast cancer risk prediction in a Dutch prospective cohort
MM Lakerman et al, Genetics in Medicine, July 6, 2020

In total, 320 women developed BC. The PRS313 was significantly associated with BC (hazard ratio [HR] per SD of 1.56, 95% confidence interval [CI] [1.40–1.73]). Using 10-year risk estimates including age and the PRS313, other risk factors improved the discriminatory ability of the BOADICEA model marginally, from a C-statistic of 0.636 to 0.653.

Teaching clinicians practical genomic medicine: 7 years’ experience in a tertiary care center
RM Cohen et al, Genetics in Medicine, July 6, 2020

During 2012–2018, 774 clinicians from multiple disciplines and career stages attended 35 programs; 334 (43%) attended the 5-day extended format. Evaluations showed significant improvement of genomic literacy (mean 15.05/100 points, p?<?0.001). Residents initially had higher scores than specialists; both significantly improved, with specialists “catching up”.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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