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Hot Topics of the Day|PHGKB
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07/02/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Making sense of mutation: what D614G means for the COVID-19 pandemic remains unclear
ND Grubaugh et al. Cell, July 2, 2020

Tracking changes in SARS-CoV-2 Spike: evidence that D614G increases infectivity of the COVID-19 virus
B Korber et al, Cell, July 2, 2020

A SARS-CoV-2 variant with Spike G614 has replaced D614 as the dominant pandemic form- The consistent increase of G614 at regional levels may indicate a fitness advantage- G614 is associated with lower RT PCR Ct’s, suggestive of higher viral loads in patients- The G614 variant grows to higher titers as pseudotyped virions.

Using mobility data in the design of optimal lockdown strategies for the COVID-19 pandemic in England
R Dutta et al, ARXIV, June 29, 2020

A Systematic Review of the Digital Interventions for Fighting COVID-19: The Bangladesh Perspective
MN Islam et al, ARXIV, June 628, 2020

Human Mobility during COVID-19 in the Context of Mild Social Distancing: Implications for Technological Interventions
M Lee et al ARXIV, July 1, 2020

Diverse local epidemics reveal the distinct effects of population density, demographics, climate, depletion of susceptibles, and intervention in the first wave of COVID-19 in the United States
N Afshordi et al, ARXIV, July 1, 2020

Traffic Performance Score for Measuring the Impact of COVID-19 on Urban Mobility
Z Cui et al ARXIV, July 1, 2020

Genetic analysis of SARS-CoV-2 strains collected from North Africa: viral origins and mutational spectrum
M Lamaarti et al, BIORXIV, July 1, 2020

periscope: sub-genomic RNA identification in SARS-CoV-2 ARTIC Network Nanopore Sequencing Data
MD Parker et al, BIORXIV, July 1, 2020

Phase 1/2 Study to Describe the Safety and Immunogenicity of a COVID-19 RNA Vaccine Candidate (BNT162b1) in Adults 18 to 55 Years of Age: Interim Report
MJ Mulligan et al, MEDRXIV, July 1, 2020

Differential COVID-19 case positivity in New York City neighborhoods: socioeconomic factors and mobility
MR Lamb et al, MEDRXIV, July 2, 2020

ESTIMATING UNDERDIAGNOSIS OF COVID-19 WITH NOWCASTING AND MACHINE LEARNING: EXPERIENCE FROM BRAZIL
LP Garcia et al, MEDRXIV, July 2, 2020

A genome epidemiological study of SARS-CoV-2 introduction into Japan
S Sekizuka et al. MEDRXIV, July 1, 2020

Monitoring Depression Trend on Twitter during the COVID-19 Pandemic
Y Zhang et al, ARXIV, July 1, 2020

Genetic Associations Between Childhood Psychopathology and Adult Depression and Associated Traits in 42 998 Individuals A Meta-analysis
WA Akingbuwa et al, JAMA Psychiatry, July 1, 2020

This meta-analysis of longitudinal cohorts, which includes data on 42?998 participants, revealed significant associations between childhood psychopathology and adult polygenic scores of major depression, subjective well-being, neuroticism, insomnia, educational attainment, and body mass index but not bipolar disorder.

Association of a Polygenic Risk Score With Breast Cancer Among Women Carriers of High- and Moderate-Risk Breast Cancer Genes
S Gallagher et al, JAMA Network Open, July 1, 2020

In this case-control study of 9802 women carrying pathogenic variants of breast cancer genes, an 86–single-nucleotide variation score was associated with breast cancer risk in each of the tested carrier populations. Stratification was more pronounced for noncarriers and CHEK2 pathogenic variant carriers than for BRCA1 or BRCA2 pathogenic variant carriers.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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