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Hot Topics of the Day|PHGKB
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06/04/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Limitations of Contemporary Guidelines for Managing Patients at High Genetic Risk of Coronary Artery Disease
KG Aragam et al, JACC, June 2020

Of 47,108 study participants, 11,020 (23.4%) had CAD. The CAD PRS strongly associated with CAD (odds ratio: 1.4 per SD increase in PRS). High polygenic risk (top 20% of PRS) conferred 1.9-fold odds of developing CAD (p < 0.0001). Among primary prevention patients, high polygenic risk did not correspond with increased recommendations for statin therapy.

Artificial Intelligence: Promise, Pitfalls, and Perspective
AN Desai, JAMA, June 3, 2020

Artificial intelligence proponents have expressed particular enthusiasm about potential applications in precision medicine... Despite all those hopeful forecasts, however, the promise of AI remains to be fully realized.

Association of OPRM1 Functional Coding Variant With Opioid Use Disorder-A Genome-Wide Association Study
H Zhou et al, JAMA Psychiatry, June 3, 2020

Meta-analysis of 10?544 individuals of European ancestry with opioid use disorder and 72?163 opioid-exposed control individuals identified OPRM1 functional variant rs1799971 as associated with opioid use disorder, with replication in 2 independent samples; no significant associations were detected for individuals of African ancestry

COVID-19 Public Sentiment Insights and Machine Learning for Tweets Classification
J Samuel et al, MEDRXIV, June 3, 2020

Ethnically diverse mutations in PIEZO1 associate with SARS-CoV-2 positivity
CW Cheng et al, MEDRXIV, May 3, 2020

A comparative evaluation of dye-based and probe-based RT-qPCR assay for the screening of SARS-CoV-2 using individual and pooled-sample testing.
C Verdugo et al, MEDRXIV, June 3, 2020

Development and Prospective Validation of a Transparent Deep Learning Algorithm for Predicting Need for Mechanical Ventilation
SP Shashikumar et al, MEDRXIV, June 3, 2020

Prevalence of Asymptomatic SARS-CoV-2 Infection-A Narrative Review
DP Oran et al, Ann Int Med, June 3, 2020

Data-Driven Methods to Monitor, Model, Forecast and Control Covid-19 Pandemic: Leveraging Data Science, Epidemiology and Control Theory
T Alamo et al, ARXIV, June 1, 2020

An integrated national scale SARS-CoV-2 genomic surveillance network
COVID-19 Genomics UK, The Lancet Microbe, June 2, 2020

Results from this initiative are guiding decision makers, including the weekly reports to the UK Scientific Advisory Group for Emergencies (SAGE). This is the first time that large-scale genomic epidemiology has been used to guide and inform the public health response to a pandemic in the UK, setting the stage for genomics to be a core tool for future pandemics.

Opinion: Intercepting pandemics through genomics
WJ Kress et al, PNAS, June 3, 2020

There is an urgent need to establish a global, genomic-based biosurveillance platform, a development which would be of immense value to biosecurity, biodefense, and the economy. If implemented, this “pandemic interception system” would hugely advance our understanding of the natural world.

A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19
DR Boulware et al, NEJM, June 3, 2020

Hydroxychloroquine for the Prevention of Covid-19 — Searching for Evidence
MS Cohen, NEJM editorial, June 3, 2020


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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