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Hot Topics of the Day|PHGKB
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05/22/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

No evidence for increased transmissibility from recurrent mutations in SARS-CoV-2
LV Dorp et al, BIORXIV, May 21, 2020

Upper airway gene expression differentiates COVID-19 from other acute respiratory illnesses and reveals suppression of innate immune responses by SARS-CoV-2
E Mick et al, MEDRXIV, May 21, 2020

Early risk assessment for COVID-19 patients from emergency department data using machine learning
FS Heldt et al, MEDRXIV, May 22, 2020

Interim Analysis of Risk Factors for Severe Outcomes among a Cohort of Hospitalized Adults Identified through the U.S. Coronavirus Disease 2019 (COVID-19)-Associated Hospitalization Surveillance Network (COVID-NET)
L Kim et al, MEDRXIV, May 22, 2020

Independent factors associated with in-hospital mortality included ages 50-64, 65-74, 75-84 and 85+ years versus 18-39 years (aRR 3.11, 5.77, 7.67 and 10.98); male sex (aRR 1.30); immunosuppression (aRR 1.39); renal disease (aRR 1.33); chronic lung disease (aRR 1.31); cardiovascular disease (aRR 1.28); neurologic disorders (aRR 1.25); & diabetes (aRR 1.19).

Translating Science on COVID-19 to Improve Clinical Care and Support the Public Health Response
C del Rio et al, JAMA, May 22, 2020

This Viewpoint reviews progress to date on drug and vaccine development for COVID-19, antibody testing for demonstration of immunity and seroprevalence, and the continuing need for testing capacity to more precisely manage the public’s health as mitigation restrictions loosen during summer 2020.

Stanford virtual conference will focus on ways AI can aid COVID-19 recovery
S Lynch, Stanford University, May 20, 2020

Integrated analysis of metabolomic profiling and exome data supplements sequence variant interpretation, classification, and diagnosis
JT ALaimo et al, Eur J Human Genetics, May 22, 2020

Metabolomic data contributed to the interpretation variants in 74 individuals (43.5%) over 73 different genes. The data allowed for the reclassification of 9 variants as likely benign, 15 variants as likely pathogenic, and 3 variants as pathogenic. Metabolomic data confirmed a clinical diagnosis in 21 cases, for a diagnostic rate of 12.3% in this population.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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