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Hot Topics of the Day|PHGKB
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04/29/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Why don’t some coronavirus patients sense their alarmingly low oxygen levels?
JC Frankel, Science, April 28, 2020

Population flow drives spatio-temporal distribution of COVID-19 in China
JS Jia et al, Nature, April 29, 2020

We use mobile-phone-data-based counts of 11,478,484 people in Wuhan as they moved throughout China. We document the efficacy of quarantine in ceasing movement. We show that the distribution of population outflow from Wuhan accurately predicts the relative frequency and geographic distribution of COVID-19 infections.

Hypertension and Renin-Angiotensin-Aldosterone System Inhibitors in Patients with Covid-19
A Ip et al, MEDRXIV, April 29, 2020

A new design of an adaptive model of infectious diseases based on artificial intelligence approach: monitoring and forecasting of COVID-19 epidemic cases
B Nail et al, MEDRXIV, April 29, 2020

Sequential informed pooling approach to detect SARS-CoV2 infection
R Millioni et al, MEDRXIV, April 29, 2020

Supplementing the National Early Warning Score (NEWS2) for anticipating early deterioration among patients with COVID-19 infection
E Carr et al, MEDRXIV, April 29, 2020

The prevalence of genetic diagnoses in fetuses with severe congenital heart defects.
Nisselrooij Amber E L van et al. Genetics in medicine : official journal of the American College of Medical Genetics 2020 Apr

An ultraportable and versatile point-of-care DNA testing platform
H XU et al, Science Advances, April 28, 2020

Point-of-care testing (POCT) has broad applications in resource-limited settings. Here, a POCT platform termed POCKET (point-of-care kit for the entire test) is demonstrated that is ultraportable and versatile for analyzing multiple types of DNA in different fields in a sample-to-answer manner.

Familial hypercholesterolemia: is it time to separate monogenic from polygenic familial hypercholesterolemia?
Brandts Julia et al. Current opinion in lipidology 2020 Apr

Through genetic testing, a mutation is found in 60-80% of cases with a clinical diagnosis of definite familial hypercholesterolemia. As individuals with a polygenic basis do not follow the same inheritance pattern observed in monogenic familial hypercholesterolemia, cascade screening in individuals with a polygenic origin is not recommended.

Polygenic Scores to Assess Atherosclerotic Cardiovascular Disease Risk: Clinical Perspectives and Basic Implications.
Aragam Krishna G et al. Circulation research 2020 Apr 126(9) 1159-1177

In this review, we describe how genomic analyses of coronary artery disease have been leveraged to create polygenic risk scores. We then discuss evaluations of the clinical utility of these scores, pertinent mechanistic insights gleaned, and practical considerations relevant to the implementation of polygenic risk scores in the health care setting.

The care of patients with Duchenne, Becker and other muscular dystrophies in the COVID-19 pandemic.
Veerapandiyan Aravindhan et al. Muscle & nerve 2020 Apr

The paper discusses consensus recommendations pertaining to care of these patients during the pandemic. We address issues surrounding corticosteroid and exon skipping treatments, cardiac medications, hydroxychloroquine use, emergency/respiratory care, rehabilitation management, and the conduct of clinical trials


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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