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Hot Topics of the Day|PHGKB
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04/03/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Special report: The simulations driving the world’s response to COVID-19: How epidemiologists rushed to model the coronavirus pandemic.
D Adam, Nature News, April 2, 2020

Population based estimates of comorbidities affecting risk for complications from COVID-19 in the US
ML Adams et al, MEDRXIV, April 2, 2020

We used 2017 Behavioral Risk Factor Surveillance System (BRFSS) data (N=444,649) to estimate the proportion of US adults who report comorbidities that suggest heightened risk of complications from COVID-19. Overall 45.4% (95% CI 45.1-45.7) of adults reported any of the 6 comorbidities, increasing from 19.8% for ages 18-29 years to 80.7% for ages 80+ years

ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy
R Asselta et al, MEDRXIV, April 2, 2020

Our analysis suggests a role for TMPRSS2 variants and expression levels in modulating COVID-19 severity, a hypothesis that fosters a rapid experimental validation on large cohorts of patients with different clinical manifestations.

Covid-19 and Health Care's Digital Revolution.
Keesara Sirina et al. The New England journal of medicine 2020 Apr

As an analogue system, health care is ill equipped to cope with this swiftly emerging epidemic. The U.S. health care industry is structured on the historically necessary model of in-person interactions between patients and their clinicians.

I Have a BRCA1 Gene Mutation: The Extra Stress of COVID-19 Takes a Toll
N McCoy, blog April 2, 2020

For those who already live with uncertainty, these extraordinary times offer new challenges. For those living with hereditary risk for cancer, the increased isolation and increased time to process can also feel overwhelming.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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