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Health Equity PHGKB

Specific PHGKB|Health Equity PHGKB|Public Health Genomics and Precision Health Knowledge Base (PHGKB)

Last Posted: Apr 25, 2024
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Aspiring toward equitable benefits from genomic advances to individuals of ancestrally diverse backgrounds
(Posted Apr 25, 2024 9AM)

From the abstract: "Despite the promise of genomic technologies, their full potential remains untapped without including individuals of diverse ancestries and integrating social determinants of health (SDOHs). The NHGRI launched the 2020 Strategic Vision with ten bold predictions by 2030, including “individuals from ancestrally diverse backgrounds will benefit equitably from advances in human genomics." Meeting this goal requires a holistic approach that brings together genomic advancements with careful consideration to healthcare access as well as SDOHs to ensure that translation of genetics research is inclusive, affordable, and accessible and ultimately narrows rather than widens health disparities. "

Impact of Race, Socioeconomic Status, and Geography on Healthcare Outcomes for Children With Sickle Cell Disease in the United States: A Scoping Review
(Posted Apr 19, 2024 10AM)

From the abstract: "A large proportion of patients with sickle cell disease (SCD) identify as Black or African American (AA). Social bias and stigma in healthcare outcomes for children with SCD are impossible to explore without considering the impact of racial/cultural identity, socioeconomic status (SES), and geography. It is important to understand the current influences of social movements, expanded health insurance coverage, and telehealth on these variables when considering healthcare outcomes for patients with SCD. "

Family cascade screening for equitable identification of familial hypercholesterolemia: study protocol for a hybrid effectiveness-implementation type III randomized controlled trial
(Posted Apr 19, 2024 10AM)

From the abstract: " Familial hypercholesterolemia (FH) is a heritable disorder affecting 1.3 million individuals in the USA. Eighty percent of people with FH are undiagnosed, particularly minoritized populations including Black or African American people, Asian or Asian American people, and women across racial groups. Family cascade screening is an evidence-based practice that can increase diagnosis and improve health outcomes but is rarely implemented in routine practice, representing an important care gap. In pilot work, we leveraged best practices from behavioral economics and implementation science—including mixed-methods contextual inquiry with clinicians, patients, and health system constituents—to co-design two patient-facing implementation strategies to address this care gap..."

Genetic Researchers' Use of and Interest in Research With Diverse Ancestral Groups.
(Posted Apr 18, 2024 8AM)

From the article: " Question: Are genetic researchers interested in research with diverse ancestral groups, and how can data stewards encourage that use? Findings: In this survey study of 294 genetic researchers, significantly more respondents reported working with data from European ancestral populations than any other ancestral population, and European samples were more likely to be considered by researchers as adequate across data-steward type. Most researchers were interested in using more diverse ancestral populations and reported that increasing ancestral diversity of existing databases would enable such research. Meaning: These findings suggest that there are specific gaps in access to and composition of genetic databases, underscoring the need to boost diversity in existing research samples to improve inclusivity in genetic research practices."


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Enhanced identification of familial hypercholesterolemia using central laboratory algorithms. External Web Site Icon
Shirin Ibrahim et al. Atherosclerosis 2024 393117548
Navigating equity in global access to genome therapy expanding access to potentially transformative therapies and benefiting those in need requires global policy changes. External Web Site Icon
Tsung-Ling Lee et al. Front Genet 2024 151381172
Translational Research and Health Equity: Gene Therapies for Sickle Cell Disease as a Case Study. External Web Site Icon
Mary A Majumder et al. Ethics Hum Res 2024 46(3) 34-39
COVID-19 outcome trends by vaccination status in Canada, December 2020-January 2022. External Web Site Icon
Dam Demy, et al. Canada communicable disease report = Releve des maladies transmissibles au Canada 2024 0 0. (1-2) 40-48
Impact of COVID-19 on Acute Care Hospitalizations for Suicidality. External Web Site Icon
Dellazoppa Alicia, et al. Hospital pediatrics 2024 0 0.
Harnessing Artificial Intelligence to Address Oral Health Disparities. External Web Site Icon
Hawazin W Elani et al. JAMA Health Forum 2024 5(4) e240642
Impact of Race, Socioeconomic Status, and Geography on Healthcare Outcomes for Children With Sickle Cell Disease in the United States: A Scoping Review. External Web Site Icon
Sameerah Wahab et al. Cureus 2024 16(3) e56089
RAB32 Ser71Arg in autosomal dominant Parkinson's disease: linkage, association, and functional analyses. External Web Site Icon
Emil K Gustavsson et al. Lancet Neurol 2024
Cystic Fibrosis Foundation Evidence-Based Guideline for the Management of CRMS/CFSPID. External Web Site Icon
Deanna M Green et al. Pediatrics 2024
Population-based BRCA germline mutation screening in the Han Chinese identifies individuals at risk of BRCA mutation-related cancer: experience from a clinical diagnostic center from greater Shanghai area. External Web Site Icon
Zhiyuan Wu et al. BMC Cancer 2024 24(1) 411
Algor-ethics: charting the ethical path for AI in critical care. External Web Site Icon
Jonathan Montomoli et al. J Clin Monit Comput 2024
Development and validation of a machine learning model for prediction of type 2 diabetes in patients with mental illness. External Web Site Icon
Martin Bernstorff et al. Acta Psychiatr Scand 2024
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Novel genetic association of the Furin gene polymorphism rs1981458 with COVID-19 severity among Indian populations. External Web Site Icon
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The impact of comorbidities and economic inequality on COVID-19 mortality in Mexico: a machine learning approach. External Web Site Icon
Méndez-Astudillo Jorge, et al. Frontiers in big data 2024 0 0. 1298029
Participant flow diagrams for health equity in AI. External Web Site Icon
Jacob G Ellen et al. J Biomed Inform 2024 152104631
SARS-CoV-2 mutant spectra as variant of concern nurseries: endless variation? External Web Site Icon
Martínez-González Brenda, et al. Frontiers in microbiology 2024 0 0. 1358258
Artificial intelligence (AI) or augmented intelligence? How big data and AI are transforming healthcare: Challenges and opportunities. External Web Site Icon
K Moodley et al. S Afr Med J 2024 114(1) 22-26
Genetic counselors' and community clinicians' implementation and perceived barriers to informed consent during pre-test counseling for hereditary cancer risk. External Web Site Icon
Alexandra Capasso et al. J Genet Couns 2024
Development of a Social Risk Score in the Electronic Health Record to Identify Social Needs Among Underserved Populations: Retrospective Study. External Web Site Icon
Elham Hatef et al. JMIR Form Res 2024 8e54732
Disparities in Genetic Testing for Neurologic Disorders. External Web Site Icon
Aaron Baldwin et al. Neurology 2024 102(6) e209161
Taking the risk. A systematic review of ethical reasons and moral arguments in the clinical use of polygenic risk scores. External Web Site Icon
Lara Andreoli et al. Am J Med Genet A 2024 e63584
Artificial Intelligence in Pediatrics: Learning to Walk Together. External Web Site Icon
Kaan Can Demirbas et al. Turk Arch Pediatr 2024 59(2) 121-130
Social and demographic factors associated with receipt of a COVID-19 vaccine initial booster dose and with interval between primary series completion and initial booster dose uptake among persons aged ≥ 12 years, United States, August 2021-October 2022. External Web Site Icon
Meng Lu, et al. Vaccine 2024 0 0.
The descriptive epidemiology of pre-omicron SARS-CoV-2 breakthrough infections and severe outcomes in Manitoba, Canada. External Web Site Icon
Shaw Souradet Y, et al. Frontiers in epidemiology 2024 0 0. 1248847
Molecular characterization of SARS-CoV-2 Omicron clade and clinical presentation in children. External Web Site Icon
Scutari Rossana, et al. Scientific reports 2024 0 0. (1) 5325
Telemedicine-Enhanced Lung Cancer Screening Using Mobile Computed Tomography Unit with Remote Artificial Intelligence Assistance in Underserved Communities: Initial Results of a Population Cohort Study in Western China. External Web Site Icon
Wenjuan Tao et al. Telemed J E Health 2024
Next-generation treatments: Immunotherapy and advanced therapies for COVID-19. External Web Site Icon
Arevalo-Romero Jenny Andrea, et al. Heliyon 2024 0 0. (5) e26423
A survey on awareness, knowledge and preferences toward genetic testing among the United States general public. External Web Site Icon
Shahariar Mohammed Fahim et al. Per Med 2024
Efficacy of Community Health Worker-Delivered Family Health History-Based Breast Cancer Education and Services Among Chinese Americans. External Web Site Icon
Bertille Assoumou et al. J Cancer Educ 2024

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About Health Equity PHGKB

Health Equity PHGKB is an online, continuously updated, searchable database of genomics and precision health information and publications relevant to health equity...more

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Disclaimer: Articles listed in the Public Health Knowledge Base are selected by Public Health Genomics Branch to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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