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Hot Topics of the Day|PHGKB
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10/20/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

A global survey of potential acceptance of a COVID-19 vaccine
JV Lazarus, et al, Nature Medicine, October 20, 2020

We surveyed 13,426 people in 19 countries to determine potential acceptance rates and factors influencing acceptance of a COVID-19 vaccine. Of these, 71.5% of participants reported that they would be very or somewhat likely to take a COVID-19 vaccine, and 61.4% reported that they would accept their employer’s recommendation to do so. Differences in acceptance rates ranged from almost 90% (in China) to less than 55% (in Russia).

All eyes on a hurdle race for a SARS-CoV-2 vaccine
C Gaebler et al, Nature News, October 19, 2020

Leading COVID-19 vaccine candidates have progressed through laboratory tests at record speed. Two early clinical trials suggest that immunization delivers a favorable immune response and safety profile, but questions remain.

How obesity could create problems for a COVID vaccine- Researchers fear that vaccines might not be as effective in people who are obese, a population already highly vulnerable to COVID-19.
H Ledford, Nature News, October 20, 2020

COVID-19 Detection on Chest X-Ray and CT Scan Images Using Multi-image Augmented Deep Learning Model
K Purohit et al, BIORXIV, October 19, 2020

Structural Genetics of circulating variants affecting the SARS CoV-2 Spike / human ACE2 complex
F Ortuso et al, BIORXIV, October 19, 2020

SARS-CoV-2 genome-wide mapping of CD8 T cell recognition reveals strong immunodominance and substantial CD8 T cell activation in COVID-19 patients
SK Saini et al, BIORXV, October 19, 2020

Mutational analysis and assessment of its impact on proteins of SARS-CoV-2 genomes from India
R Laskar et al, BIORXIV, October 19, 2020

An engineered decoy receptor for SARS-CoV-2 broadly binds protein S sequence variants
KK Chan et al, BIORXIV, October 19, 2020

Diversity and genomic determinants of the microbiomes associated with COVID-19 and non-COVID respiratory diseases
MN Hoque et al, BIORXIV, October 19, 2020

Antibody responses to SARS-CoV-2 train machine learning to assign likelihood of past infection during virus emergence in Sweden
X Castro et al, MEDRXIV, October 19, 2020

Towards Improved Social Distancing Guidelines: Space and Time Dependence of Virus Transmission from Speech-driven Aerosol Transport Between Two Individuals
F Yang et al, MEDRXIV, October 19, 2020

LAMP-BEAC: Detection of SARS-CoV-2 RNA Using RT-LAMP and Molecular Beacons
SS Mix et al, MEDRXIV, October 19, 2020

My Brother Died of Brain Cancer. 20 Years Later, I Had It, Too. I was told it didn’t run in families. Was it just chance?
S Hashmi, NY Times, October 20, 2020

Medical research is on their side. It shows there’s only a 5 percent chance of brain tumors being hereditary. My brother was the first among our eight uncles and aunts and 19 cousins, and now I’m the second.

Detection of early stage pancreatic cancer using 5-hydroxymethylcytosine signatures in circulating cell free DNA
GD Guler et al, Nature Comms, October 19, 2020

Pancreatic cancer is often detected late, when curative therapies are no longer possible. Here, we present non-invasive detection of pancreatic ductal adenocarcinoma (PDAC) by 5-hydroxymethylcytosine (5hmC) changes in circulating cell free DNA from a PDAC cohort (n?=?64) in comparison with a non-cancer cohort (n?=?243).

Mutations associated with neuropsychiatric conditions delineate functional brain connectivity dimensions contributing to autism and schizophrenia
CA Moreau et al, Nature Comms, October 19, 2020

16p11.2 and 22q11.2 Copy Number Variants (CNVs) confer high risk for Autism Spectrum Disorder (ASD), schizophrenia (SZ), and Attention-Deficit-Hyperactivity-Disorder (ADHD), but their impact on functional connectivity (FC) remains unclear. Here we report an analysis of resting-state FC using magnetic resonance imaging data from 101 CNV carriers, 755 individuals with idiopathic ASD, SZ, or ADHD and 1,072 controls.

Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel A Meta-analysis
BW Kunkle et al, JAMA Neurology, October 19, 2020

In this genome-wide association meta-analysis of 2748 individuals with Alzheimer disease and 5222 controls, several novel genetic loci and pathways associated with Alzheimer disease in African American individuals were identified.

Variation in Breast Cancer Subtype Incidence and Distribution by Race/Ethnicity in the United States From 2010 to 2015
X Kong et al, JAMA Network Open, October 19, 2020

In this cohort study of 239 211 women with breast cancer, the incidence of HR-negative and ERBB2 positive, HR-positive and ERBB2-positive, and triple-negative breast cancer was higher in Black women compared with non-Hispanic White women. The incidence of histological grade 1 and 2 cancer was lower in Asian/Pacific Islander than non-Hispanic White patients.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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