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Hot Topics of the Day|PHGKB
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08/29/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Saliva or Nasopharyngeal Swab Specimens for Detection of SARS-CoV-2.
Wyllie Anne L et al. The New England journal of medicine 2020 Aug

Given the growing need for testing, our findings provide support for the potential of saliva specimens in the diagnosis of SARS-CoV-2 infection. Collection of saliva samples by patients negates the need for interaction with health care workers, a source of testing bottlenecks. This also alleviates demands for supplies of swabs and personal protective equipment.

Scientists are reporting several cases of Covid-19 reinfection — but the implications are complicated
A Joseph, Stat News, August 28, 2020

Challenges for the evaluation of digital health solutions—A call for innovative evidence generation approaches
C Guo et al, NPJ Digital Medicine, August 27, 2020

The aim of this article is to: (1) Review current research approaches and discuss their limitations; (2) Discuss challenges faced by different stakeholders in undertaking evaluations; and (3) Call for new approaches to facilitate the safe and responsible growth of the digital health sector.

Genetics meets proteomics: perspectives for large population-based studies
K Suhre et al, Nature Rev Genetics, August 28, 2020

We review current findings from studies of the plasma proteome and discuss their potential for advancing biomedical translation through the interpretation of genome-wide association analyses. We highlight the challenges faced by currently available technologies and provide perspectives relevant to their future application in large-scale biobank studies.

Successful application of genome sequencing in a diagnostic setting: 1007 index cases from a clinically heterogeneous cohort
AM Bertoli-Avella et al, EJHG, August 28, 2020

We analyzed 1007 consecutive index cases for whom genome sequencing was performed in a diagnostic setting over a 2-year period. We reported pathogenic and likely pathogenic (P/LP) variants that explain the patients’ phenotype in 212 of the 1007 cases (21.1%).

Revisiting Health Care System Data Priorities to Improve Population Health and Address Inequity
CC Kenyon et al, JAMA Health Forum, August 28 2020

As we enter a new phase of the COVID-19 pandemic, cognizant of the unequal outcomes it has had in local communities, health care systems have the opportunity to revisit their priorities around what data can best support the ongoing surveillance and protection of the populations they serve.

US racial inequality may be as deadly as COVID-19.
Wrigley-Field Elizabeth et al. Proceedings of the National Academy of Sciences of the United States of America 2020 Aug

White life expectancy in 2020 will be higher than Black life expectancy has ever been unless nearly 700,000 excess White deaths occur. Even amid COVID-19, White mortality is likely to be less than what Blacks have experienced every year. If Black disadvantage operates on the scale of Whites’ experience of COVID-19, so too should the tools we deploy to fight it.


Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Public Health Genomics to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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