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Hot Topics of the Day|PHGKB
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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Population-scale longitudinal mapping of COVID-19 symptoms, behaviour and testing
WE Allen et al, Nature Human Behavior, August 26, 2020

We developed How We Feel, a web and mobile application that collects longitudinal self-reported survey responses on health, behavior and demographics. Here, we report results from over 500,000 users in the United States. We show that self-reported surveys can be used to build predictive models to identify likely COVID-19-positive individuals.

Sex differences in immune responses that underlie COVID-19 disease outcomes
T Takahashi et al, Nature, August 26, 2020

Male patients had higher plasma levels of innate immune cytokines such as IL-8 and IL-18 along with more robust induction of non-classical monocytes. Female patients mounted significantly more robust T cell activation than male patients during SARS-CoV-2 infection. Importantly, we found that a poor T cell response negatively correlated with patients’ age and was associated with worse disease outcome in male patients, but not in female patients.

Two metres or one: what is the evidence for physical distancing in covid-19?
NR Jones et al, BMJ, August 25, 2020

Instead of single, fixed physical distance rules, we propose graded recommendations that better reflect the multiple factors that combine to determine risk. This would provide greater protection in the highest risk settings but also greater freedom in lower risk settings, potentially enabling a return towards normality in some aspects of social and economic life.

Changes in mobility patterns in Europe during the COVID-19 pandemic: Novel insights using open source data
AS Islind et al. ARXIV, August 24, 2020

Blockchain-enabled Internet of Medical Things to Combat COVID-19
HN Dai et al, ARXIV, August 23, 2020

“My disability has become an ability”
E Manna, Nature Medicine, August 24, 2020

I can feel that we are at a turning point. More and more, people living with medical conditions are beginning to realize that they do have a voice. This is fantastic, because if it were not for patients, everybody would be out of a job.

The value of genomic sequencing in complex pediatric neurological disorders: a discrete choice experiment.
Goranitis Ilias et al. Genetics in medicine : official journal of the American College of Medical Genetics 2020 Aug

On average, society highly values all diagnostic, process, clinical, and nonclinical components of personal utility. To ensure fair prioritization of genomics, decision makers need to consider the wide range of risks and benefits associated with genomic information.

Alaska Native genomic research: perspectives from Alaska Native leaders, federal staff, and biomedical researchers.
Hiratsuka Vanessa Y et al. Genetics in medicine : official journal of the American College of Medical Genetics 2020 Aug

The National Human Genome Research Institute and two Alaska Native health organizations, Southcentral Foundation and the Alaska Native Health Board, cosponsored a workshop to engage key stakeholders in discussion, strengthen relationships, and facilitate partnership and consideration of participation of AN people in community-driven biomedical and genomic research.

Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Public Health Genomics to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.