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Hot Topics of the Day|PHGKB
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08/13/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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An Inactivated Virus Candidate Vaccine to Prevent COVID-19
MJ Mulligan, JAMA, August 13, 2020

Genetic immunization approaches are particularly suited to a rapid pandemic response. While no genetic immunization vaccine has ever been licensed by the FDA for human use, these platforms hold great promise. Genetic immunization candidates can be seen as mimics of natural infection or of traditional live-attenuated vaccines, like the measles-mumps-rubella vaccine.

The Role of Host Genetic Factors in Coronavirus Susceptibility: Review of Animal and Systematic Review of Human Literature
M LoPresti et al, AJHG, August 12, 2020

We reviewed the literature on host genetic factors related to coronaviruses. We identified 1,832 articles of potential relevance. 75 involved human host genetic factors, of which 35 involved analysis of specific genes or loci; aside from one meta-analysis, all were candidate-driven studies, typically investigating small numbers of research subjects and loci.

Predicting Critical State after COVID-19 Diagnosis Using Real-World Data from 20152 US Patients
MDR et al, MedRXIV, AUgust 11, 2020

The selection of reference genome and the search for the origin of SARS-CoV-2
Y Liu et al BIORXIV, August 11, 2020

Factors Associated with Disease Severity and Mortality among Patients with Coronavirus Disease 2019: A Systematic Review and Meta-Analysis
V Chidambaram et al, MEDRXIV, August 13, 2020

109 articles were included. The risks of mortality or severe diseases were higher in patients with increasing age, male gender, dyspnea, diabetes, hypertension, congestive heart failure, hilar lymphadenopathy, bilateral lung involvement and reticular pattern.

Causal Genetic Variants in Stillbirth
KE Stanley et al, NEJM, August 12, 2020

We identified molecular diagnoses in 15 of 246 cases of stillbirth (6.1%) involving seven genes that have been implicated in stillbirth and in six disease genes that are good candidates for phenotypic expansion.

Genomic Insights into Stillbirth
MH Wojick, NEJM, August 12, 2020

New findings suggest not only that many genetic conditions remain to be discovered but that the full phenotypic spectrum of many known mendelian disorders is not fully understood without the inclusion of cases resulting in death in utero.

Epigenetic Therapies for Cancer
SE Bates. NEJM, August 12, 2020

Epigenetics is a field approaching its 50th anniversary. In 2020, despite the availability of nine approved epigenetic agents, most advances in the epigenetic treatment of hematologic cancers and solid tumors remain a work in progress.

Application of Machine Learning Techniques to Analyze Patient Returns to the Emergency Department
AS Cabuzuelo et al, J Per Med, August 2020

The study of the quality of hospital emergency services is based on analyzing a set of indicators such as the average time of first medical attention, the average time spent in the emergency department, degree of completion of the medical report and others. We analyze one quality indicator: the rate of return of patients to emergency service <72 h from discharge.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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