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Hot Topics of the Day|PHGKB
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07/30/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Integrating Personalized Medicine With Population Health Management- The Path Forward
DC Grossman et al, July 30, 2020

While genomics and personalized medicine may be a key to population health, the way forward will be costly, wasteful, and potentially harmful without the establishment of priorities, adherence to rules of evidence, and the patience to wait for outcomes to unfold over years of observation.

Eleven Routine Clinical Features Predict COVID-19 Severity
K Xhou et al, MEDRXIV, July 29, 2020

Using influenza surveillance networks to estimate state-specific prevalence of SARS-CoV-2 in the United States.
Silverman Justin D et al. Science translational medicine 2020 Jun

The authors estimated the proportion of observed influenza-like illness during the early pandemic that was in excess of the seasonal variation seen in prior years, then adjusted this estimate to take into account subclinical infections. Their model estimated that more than 80% of individuals with SARS-CoV-2 infections in the US went undetected in March 2020.

Prognostic Gene Expression Profiling in Cutaneous Melanoma Identifying the Knowledge Gaps and Assessing the Clinical Benefit
D Grossman et al, JAMA Dermatology, July 29, 2020

Before gene expression profile testing is routinely used, the clinical benefit to the management of patients with melanoma must be established through further clinical investigation.

Consensus, Controversy, and Conversations About Gene Expression Profiling in Melanoma
WH Chan et al, JAMA Dermatology, July 29, 2020

Performance of Gene Expression Profile Tests for Prognosis in Patients With Localized Cutaneous Melanoma A Systematic Review and Meta-analysis
MA Marchetti et al, JAMA Dermatology, July 29, 2020

Adopting consistent terms for genetic testing in precision medicine
C Jett, NSGC Blog, July 28, 2020

Patients and providers may be overwhelmed by the complexities of testing and lack a common vocabulary to begin meaningful discussion. Without a shared language to help bridge this knowledge gap, patients may be unwilling to ask for testing and providers may be unwilling to offer it.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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