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Hot Topics of the Day|PHGKB
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07/23/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Why do asymptomatic COVID-19 cases even happen?
SE Richards, National Geographic, July 22, 2020y

Health officials are concerned about why some people who test positive for the coronavirus never feel sick. Could it be the luck of genetics? The blessings of youth? Or something else?

Coronavirus vaccines leap through safety trials — but which will work is anybody’s guess
E Callaway, Nature News, July 21, 2020

Scientists caution against comparing immune responses shown in early-stage trials, and say there might be more than one path to an effective vaccine.

Automated Detection and Forecasting of COVID-19 using Deep Learning Techniques: A Review
A Shoeibi et al, ARXIV< July 2020

Internet of Things for Current COVID-19 and Future Pandemics: An Exploratory Study
M Nasajpour et al, ARXIV, July 22, 2020

Comparative ACE2 variation and primate COVID-19 risk
AD Melin et al, BIORXIV, July 21, 2020

THE ORIGIN OF A NEW HUMAN VIRUS: PHYLOGENETIC ANALYSIS OF THE EVOLUTION OF SARS-COV-2
MJ Pereson et al, BIORXIV, July 21, 2020

The discovery of a recombinant SARS2-like CoV strain provides insights into SARS and COVID-2019 pandemics
X Li et al, BIORXIV, July 22, 2020

Elucidation of Genome Polymorphisms in Emerging SARS-CoV-2
M Ray et al, BIORXIV, July 22, 2020

The Trans-omics Landscape of COVID-19
P Wu et al, MEDRXIV, July 22, 2020

The hunt for the origins of SARS-CoV-2 will look beyond China- The virus may have been born in South-East Asia
The Economist, July 22, 2020

Rapid Scaling Up of Covid-19 Diagnostic Testing in the United States — The NIH RADx Initiative
BJ Tromberg et al, NEJM, July 22, 2020

The program will accelerate the development of, scale up of innovative point-of-care technologies as early as the fall of 2020. It will support the scale-up of somewhat more advanced technologies that can achieve immediate, substantial increases in capacity. It will establish community-engaged implementation projects to improve access underserved populations.

Covid-19 and Health Equity — Time to Think Big
SA Berkowitz et al, NEJM, July 22, 2020

he Covid-19 pandemic has exposed the magnitude of U.S. health inequities — which the World Health Organization defines as “avoidable, unfair, or remediable differences” in health. It has also highlighted structural racism — institutions, practices, and policies that differentially allocate opportunities so as to increase inequity among racial groups.

Group-based pharmacogenetic prediction: is it feasible and do current NHS England ethnic classifications provide appropriate data?
Ingram Catherine J E et al. The pharmacogenomics journal 2020 Jul

We show that publicly available population information is potentially useful for determining loci for pre-treatment genetic testing, and for determining the most prevalent risk haplotypes in defined groups. However, we also show that the NHS England classifications have limitations for grouping for these purposes, in particular for people of African descent.

Polygenic Risk Scores in Clinical Practice
NSGC, Online Course, July 2020

This online course provides learners with the foundational background needed to feel comfortable evaluating and interpreting a PRS and communicating polygenic risk information to patients. Objectives: State the background of PRS development. Summarize the possibilities and limitations of PRS. Critique use in clinical practice.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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