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Hot Topics of the Day|PHGKB
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07/09/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

No evidence of viral polymorphisms associated with Paediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2 (PIMS-TS).
J Pang et al, MEDRXIV, July 8, 2020

Modeling reductions in SARS-CoV-2 transmission and hospital burden achieved by prioritizing testing using a clinical prediction rule
JR Rimer et al, MEDRXIV, July 98 2020

COVID-19 Mortality Risk Assessment: An International Multi-Center Study
D Berstimas et al, MEDRXIV, July 9, 2020

SARS-CoV-2 virus culture from the upper respiratory tract: Correlation with viral load, subgenomic viral RNA and duration of illness.
R Perera et al, MEDRXIV, July 9, 2020

Risk Factors Prediction, Clinical Outcomes, and Mortality of COVID-19 Patients
R Alizadehsani et al. MEDRXIV, July 9, 2020

Diagnostic and prognostic value of hematological and immunological markers in COVID-19 infection: A meta-analysis of 6320 patients
R ElShazli et al, MEDRXIV, July 9, 2020

The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types
Z Daniloski et al BIORXIV, July 7, 2020

Whole-Genome Sequences of the Severe Acute Respiratory Syndrome Coronavirus-2 obtained from Romanian patients between March and June of 2020
M Lazar et al, BIORXIV, July 7, 2020

An Evaluation of Publicly Available Deep Learning Based Commercial Information Retrieval Systems to search Biomedical Articles related to COVID-19
S Soni et al. ARXIV, July 6, 2020

Contact Tracing: An Overview of Technologies and Cyber Risks
F Legendre et al, ARXIV, July 6, 2020

Children’s rare disease cohorts: an integrative research and clinical genomics initiative
S Rockowitz et al, NPJ Genomic Medicine, July 6, 2020

We have developed a broadly sharable database of 2441 exomes from 15 pediatric rare disease cohorts, with major contributions from early onset epilepsy and early onset inflammatory bowel disease. All sequencing data is integrated and combined with phenotypic and research data in a genomics learning system (GLS).

The Beginning of Genomic Therapies for ALS.
Hardiman Orla et al. The New England journal of medicine 2020 Jul (2) 180-181

Two studies have shown that a precision-medicine approach to the treatment of neurodegenerative conditions associated with single mutated genes may be within reach. But the studies were not powered to provide evidence of efficacy.

Phase 1-2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS.
Miller Timothy et al. The New England journal of medicine 2020 Jul (2) 109-119

SOD1 Suppression with Adeno-Associated Virus and MicroRNA in Familial ALS.
Mueller Christian et al. The New England journal of medicine 2020 Jul (2) 151-158

Clearing the path for gene therapy
B Gyorgy, Sci Trans Med, July 8, 2020

Gene therapy is a clinical reality, and product development is progressing at an astonishing speed. According to a Food and Drug Administration commissioner statement, with 10 to 20 new approved products per year, gene and cell therapies may potentially represent up to 40% of all new drug output by 2025.

A New FDA Approval Furthers the Role of Genomics in Cancer Care
NCI Director blog, July 8, 2020 Brand

A recent drug approval by the Food and Drug Administration (FDA) marks another milestone in the treatment of cancer. The action by FDA expands the growing list of approved uses for the immune checkpoint inhibitor pembrolizumab


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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