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Hot Topics of the Day|PHGKB
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07/31/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Bringing monogenic disease screening to the clinic
MF Murray et al, Nature Medicine, July 31, 2020

The Healthy Nevada Project shows that otherwise invisible disease risk can be revealed through DNA-based screening. Identifying these monogenic risks could be the first step toward a new population health-screening program.

What We Know About COVID-19’s Effects on Child and Maternal Health
NIH Director's Blog, July 31, 2020 Brand

Association between Alzheimer's disease and COVID-19: A bidirectional Mendelian randomization
D Liu et al, MEDRXIV, July 30, 2020

Initial evaluation of a mobile SARS-CoV-2 RT-LAMP testing strategy
C Newman et al, MEDRXIV, July 30, 2020

How does SARS-CoV-2 cause COVID-19?
NJ Matheson, et al, Science, July 31, 2020

As with all coronaviruses, SARS-CoV-2 cell entry is dependent on its 180-kDa spike (S) protein, which mediates two essential events: binding to ACE2 by the amino-terminal region, and fusion of viral and cellular membranes through the carboxyl-terminal region.

Swabs Collected by Patients or Health Care Workers for SARS-CoV-2 Testing.
Tu Yuan-Po et al. The New England journal of medicine 2020 07 (5) 494-496

Our study shows the clinical usefulness of tongue, nasal, or mid-turbinate samples collected by patients as compared with nasopharyngeal samples collected by health care workers for the diagnosis of Covid-19.

Covid's Color Line - Infectious Disease, Inequity, and Racial Justice.
Evans Michele K et al. The New England journal of medicine 2020 Jul (5) 408-410

Drug treatments for covid-19: living systematic review and network meta-analysis
RAC Siemieniuk et al, BMJ, July 30, 2020

Glucocorticoids probably reduce mortality and mechanical ventilation in patients with covid-19 compared with standard care. The effectiveness of most interventions is uncertain because most of the randomised controlled trials so far have been small and have important study limitations.

Strategies to enable large-scale proteomics for reproducible research
RC Poulos et al, Nature Comms, July 30, 2020

Reproducible research is the bedrock of experimental science. To enable the deployment of large-scale proteomics, we assess the reproducibility of mass spectrometry (MS) over time and across instruments and develop computational methods for improving quantitative accuracy.

Molecular Profiling of Thyroid Nodules—Are These Findings Meaningful, or Merely Measurable?
LGT Morris, JAMA Oto Larnyg, July 30, 2020

Advances in genomic technologies have facilitated the development of sophisticated molecular diagnostic tests for thyroid nodules, in the hopes of better risk stratifying nodules with indeterminate cytopathologic diagnosis. It is unclear whether the widespread, or reflexive, use of these tests will improve outcomes for patients with thyroid nodules.

Clinical deployment of AI for prostate cancer diagnosis
A Janowscyk, Lancet Digital Health, August 1, 2020

Algorithms capable of elevating general pathologists' performance to that of highly trained specialists, in particular drawing attention to cases that might warrant specialist review, have the potential to substantially raise the standard of care.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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