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Hot Topics of the Day|PHGKB
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06/29/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

This coronavirus mutation has taken over the world. Scientists are trying to understand why.
S Kaplan et al, Washington Post, June 29, 2020

A race to determine what drives COVID-19 severity
M Koutsakos et al, Nature News, June 29, 2020

Efforts are ongoing to find which human or viral factors underpin whether a person with COVID-19 will develop severe symptoms. Clinical evidence linked to two viral lineages now provides key insights into this enigma.

Machine-Learning Driven Drug Repurposing for COVID-19
D Canturk et al, ARXIV, June 25, 2020

An Interactive Data Visualization and Analytics Tool to Evaluate Mobility and Sociability Trends During COVID-19
F Zhao et al, ARXIV, June 26, 2020

Social media and smartphone app use predicts maintenance of physical activity during Covid-19 enforced isolation in psychiatric outpatients
A Norbury et al, MEDRXIV, June 28, 2020

Impact of the accuracy of case-based surveillance data on the estimation of time-varying reproduction numbers
M Starnini et al, MEDRXIV, June 28, 2020

https://www.medrxiv.org/content/10.1101/2020.06.26.20140764v1
F Sumika et al, MEDRXIV, June 28, 2020

Sample Pooling as a Strategy of SARS-COV-2 Nucleic Acid Screening Increases the False-negative Rate
Y Gan et al, MEDRXIV, June 28, 2020

Deep phenotyping of 34,128 patients hospitalised with COVID-19 and a comparison with 81,596 influenza patients in America, Europe and Asia: an international network study
E Burn et al, MEDRXIV, June 28, 2020

Genetic ancestry analysis on >93,000 individuals undergoing expanded carrier screening reveals limitations of ethnicity-based medical guidelines
KE Kaseniit et al, Genetics in Medicine, June 29, 2020

For 93,419 individuals undergoing expanded carrier screen, correspondence was assessed among carrier status, self-reported ethnicity, and genetic ancestry calculated from sequencing data. Self-reported ethnicity was an imperfect indicator of genetic ancestry, with 9% of individuals having >50% genetic ancestry inconsistent with self-reported ethnicity.

How digital tools can advance quality and equity in genomic medicine
Y Bombard et al, Nat Rev Genetics, June 29, 2020

Now more than ever, digital applications are essential to accessing genetics services and optimizing their delivery. At this watershed moment, digital solutions must be balanced with the merits of human interaction, without compromising quality or exacerbating existing genomic and technological disparities.

A ‘Cure for Heart Disease’? A Single Shot Succeeds in Monkeys
G Kolata, NY Times, June 27, 2020

In the first gene-editing experiment of its kind, scientists have disabled two genes in monkeys that raise the risk for heart disease (PCSK9 and LDL). Humans carry the genes as well, and the experiment has raised hopes that a leading killer may one day be tamed.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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