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Hot Topics of the Day|PHGKB
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06/12/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Using Digital Data to Protect and Promote the Most Vulnerable in the Fight Against COVID-19
R Chunara et al, Frot Public Health, June 12, 2020

The digital divide shows that the most vulnerable (e.g., elderly, certain socioeconomic or cultural groups) may not often have access to the same digital tools, nor follow the same patterns of illness and reporting as other populations. This may present issues when population-level inferences are to be made from such data.

Proteomic Profiling in Biracial Cohorts Implicates DC-SIGN as a Mediator of Genetic Risk in COVID-19
DH Katz et al, MEDRXIV, June 11, 2020

Recent work has identified two genetic risk loci that confer greater risk for respiratory failure in COVID-19: the ABO locus and the 3p21.31 locus. To understand how these loci might confer risk, we utilized proteomic profiling and genetic information from three cohorts including black and white participants to identify proteins influenced by these loci.

Artificial-intelligence tools aim to tame the coronavirus literature
M Hutson, Nature, June 11, 2020

Driven by a combination of factors — including the availability of a large collection of relevant papers, advances in natural-language processing (NLP) technology — AI tools find the studies that are most relevant to the user, and in some cases to extract specific findings from the results.

Sex differences in immune responses to SARS-CoV-2 that underlie disease outcomes
T Takahashi et al, MEDRXIV, June 9, 2020

Prevalence of Gastrointestinal Symptoms and Fecal Viral Shedding in Patients With Coronavirus Disease 2019 A Systematic Review and Meta-analysis
S Parasa et al, JAMA Network Open, June 11, 2020

This systematic review of 23 published and 6 preprint studies found that approximately 12% of patients with SARS-CoV-2 infection reported gastrointestinal symptoms, including diarrhea, nausea, and vomiting. Liver enzyme levels outside reference ranges were observed in 15%-20% of patients, and RNA shedding in stool was detected in up to 41% of patients.

Lots of us are infected by the coronavirus — and don’t know it. Here’s what that means.
DP Oran et al, Washington Post, June 11, 2020

Clinical Genetics Lacks Standard Definitions and Protocols for the Collection and Use of Diversity Measures.
Popejoy Alice B et al. American journal of human genetics 2020 Jun

Genetics researchers and clinical professionals rely on diversity measures such as race, ethnicity, and ancestry (REA) to stratify study participants and patients for a variety of applications in research and precision medicine. However, there are no comprehensive, widely accepted standards or guidelines for collecting and using such data in genetics practice

Better Biomarkers for Surgeons Treating Cancer
DL Bartlett, JAMA Surgery, June 10, 2020


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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