Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content


Hot Topics of the Day|PHGKB
Search PHGKB:

06/01/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

Sign up MyPHGKB to receive the daily hot topic email alert.

Search Archive:
Archived Hot Topics of the Day By Date

A precision public health approach to preventing the next COVID-19 surge: it’s time to talk about surveillance
M Matone blog, The Incidental Economist, May 2020

We propose a contrasting approach that includes a number of synchronous activities: An enhanced surveillance model featuring syndromic and participatory methods, prioritized testing for high-risk populations, and community-level quarantine protocols.

Better patient identification could help fight the coronavirus
B Mocovich et al NPJ Digital Medicine, June 1, 2020

Public health relies on information from hospitals, clinics, laboratories, and other sources that indicate whether, when, and where individuals have tested positive. The sharing of more data and use of standards—reflect near-term opportunities that government and health-care organizations can implement to respond to the current pandemic and prepare for future ones.

Disparities in Vulnerability to Severe Complications from COVID-19 in the United States
E Winners et al, MEDRXIV, May 31, 2020

Utility and limitations of Google searches for tracking disease: the case of taste and smell loss as markers for COVID-19
K Asseo et al, MEDRXIV, May 31, 2020

An inflammatory cytokine signature helps predict COVID-19 severity and death
DM Del Valle et al, MEDRXIV, May 30, 2020

Genetic risk factors for Alzheimer’s also raise the risk of getting COVID-19--It’s unclear how the APOE4 gene variant may make people more vulnerable to the coronavirus
TH Saey, Science News, May 29, 2020

Jeffrey's insights: Jeffrey Modell Foundation's global genetic sequencing pilot program to identify specific primary immunodeficiency defects to optimize disease management and treatment.
Quinn Jessica et al. Immunologic research 2020 May

158 patients and 29 relatives were tested in this pilot study. 21% of patients with a suspected monogenic disorder received a molecular diagnosis. Clinical diagnosis was altered in 45% of patients, disease management was altered in 40%, treatment was altered in 36%, and genetic counseling was altered in 62%. The pilot program the importance of NGS for PI.

The interface of genomic information with the electronic health record: a points to consider statement of the American College of Medical Genetics and Genomics (ACMG)
TA Grebe et al, Genetics in Medicine, June 1, 2020

This document discusses types of genomic information in the EHR, mechanisms of placement, data entry, usage, patient/provider access, results disclosure, portability, and privacy. It highlights patient, family, and societal benefits; discuss areas of concern, identifying where modifications are needed; and make recommendations for optimization.

Automated syndrome diagnosis by three-dimensional facial imaging
B Hallgrimsson et al, Genetics in Medicine, June 1, 2020

We analyzed variation in three-dimensional (3D) facial images of 3327 subjects with 396 different syndromes, 727 of their relatives, and 3003 unrelated, unaffected subjects. Machine learning correctly classified diagnoses with 96% accuracy. Considering both syndromic and unrelated, unaffected subjects together, balanced accuracy was 73% and mean sensitivity 49%.

NIH releases strategic plan to accelerate nutrition research over next 10 years
NIH, May 27, 2020 Brand

What if each of us had individualized dietary recommendations that helped us decide what, when, why, and how to eat to optimize our health and quality of life? This precision nutrition approach — developing targeted and effective diet interventions in a diverse population — is among the ambitious goals set out by the 2020-2030 Strategic Plan

Microbial matters: modelling the complex web of host–microbiome interactions
M Eisenstein, Nature, May 2020

Computational approaches help to map the extensive biochemical chatter between bacteria and their human hosts. Researchers are developing mathematical and statistical approaches that use a range of data, from areas such as genomics and biochemistry, to reconstruct highly diverse gut microbial communities computationally.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
TOP