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Hot Topics of the Day|PHGKB
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05/13/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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The COVID-19 Host Genetics Initiative, a global initiative to elucidate the role of host genetic factors in susceptibility and severity of the SARS-CoV-2 virus pandemic
The COVID-19 Host Genetics Initiative, EJHG, May 13, 2020

The initiative has 3 goals: Provide an environment to foster sharing of resources to facilitate host genetics research; Organize analytical activities across studies to identify genetic determinants of susceptibility and severity; Provide a platform to share results, as well as the individual-level data where possible, to benefit the broader scientific community.

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19
M Liao et al, Nature Medicine, May 12, 2020

Development and Validation of a Clinical Risk Score to Predict the Occurrence of Critical Illness in Hospitalized Patients With COVID-19
W Liang et al, JAMA Internal Medicine, May 12, 2020

In this study with a development cohort of 1590 patients and a validation cohort of 710 patients, a risk score was developed and validated to predict development of critical illness. We identified 10 independent predictors and developed a risk score (COVID-GRAM) that predicts development of critical illness

Exploring diseases/traits and blood proteins causally related to expression of ACE2, the putative receptor of SARS-CoV-2: A Mendelian Randomization analysis highlights tentative relevance of diabetes-related traits
S Rao et al, MEDRXIV, May 12, 2020

Serum protein profiling reveals a landscape of inflammation and immune signaling in early-stage COVID-19 infection
X Hou et al, MEDRXIV, May 13, 2020

Defining the Pandemic at the State Level: Sequence-Based Epidemiology of the SARS-CoV-2 virus by the Arizona COVID-19 Genomics Union (ACGU)
JD Ladner et al, MEDRXIV, May 13, 2020

Phylogenetic analysis of 79 genomes we generated from across Arizona revealed a minimum of 9 distinct introductions throughout February and March. We show that >80% of our sequences descend from clades that were initially circulating widely in Europe but have since dominated the outbreak in the United States.

Saliva as a non-invasive sample for the detection of SARS-CoV-2: a systematic review
Z Khurshid et al, MEDRXIV, May 13, 2020

Epidemic Models for Personalised COVID-19 Isolation and Exit Policies Using Clinical Risk Predictions
T Evgeniou et al, MEDRXIV, May 12, 2020

Predicting the Growth and Trend of COVID-19 Pandemic using Machine Learning and Cloud Computing
S Tuli, et al, MEDRXIV, May 11, 2020

Genome-wide data inferring the evolution and population demography of the novel pneumonia coronavirus (SARS-CoV-2)
B Fang et al, BIORXIV, May 11, 2020

Nearly 40% of Icelanders are using a covid app—and it hasn’t helped much- The country has the highest penetration of any automated contact tracing app in the world, but one senior figure says it “wasn’t a game changer.”
M Johnson, MIT Tech Review, May 11, 2020

COVID-19 outcomes and the human genome
MF Murray et al, Genetics in Medicine, May 13, 2020

Human infection is a complex interaction between microbe, environment, and human host. Host genomic variability has been linked to complications associated with infections. The ability to identify host factors that increase susceptibility or resistance to complications of COVID-19 and to translate findings to improved patient care should be the goal.

Big Data Begin in Psychiatry
MM Weissman, JAMA Psychiatry, May 13, 2020

The review traces the subsequent evolution of big data in psychiatry to 5 overlapping phases, other population surveys in the US and globally, cohort studies, administrative claims, large genetic data sets, and electronic health records.

All Hands on Deck! Geospatial Mapping in Outbreaks
ATSDR, May 2020

To visualize the outbreak on the cruise ship, a 3-dimensional (3D) model of the cruise ship mapped rooms that had sick passengers to visualize the spatial relationships between the sick passengers and the locations of their staterooms. Without the 3D model of the cruise ship, investigators may not have identified potential important moments in the outbreak


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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