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Hot Topics of the Day|PHGKB
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05/07/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Modeling shield immunity to reduce COVID-19 epidemic spread
JS Weitz et al, Nature Medicine, May 7, 2020

We have developed and analyzed an epidemiological intervention model that leverages serological tests6,7 to identify and deploy recovered individuals8 as focal points for sustaining safer interactions via interaction substitution, developing what we term ‘shield immunity’ at the population scale.

The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice
L Bao, et al, Nature, May 7, 2020

We used transgenic mice bearing human ACE2 and infected with SARS-CoV-2 to study and confirmed the pathogenicity of the virus. The mouse model with SARS-CoV-2 infection will be valuable for evaluating antiviral therapeutics and vaccines as well as understanding the pathogenesis of COVID-19.

First Data-Set on SARS-CoV-2 Detection for Istanbul Wastewaters in Turkey
BA Kocamemi et al, MEDRXIV, May 6, 2020

Evaluation of lockdown impact on SARS-CoV-2 dynamics through viral genome quantification in Paris wastewaters
S Wurtzer et al, MEDRXIV, May 6, 2020

We confirmed that the increase of genome units in raw wastewaters followed the increase of human COVID-19 cases. Viral genomes could be detected before the exponential growth of the epidemic. A marked decrease in the quantities of genome units was observed with the reduction in the number of new cases which was an expected consequence of the lockdown.

The Problem With Stories About Dangerous Coronavirus Mutations- There’s no clear evidence that the pandemic virus has evolved into significantly different forms—and there probably won’t be for months.
E Yong, the Atlantic, May 6, 2020

The VODAN IN: support of a FAIR-based infrastructure for COVID-19
B Mons, Eur J Hum Genetics, May 6, 2020

The epidemiologic parameters for COVID-19: A Systematic Review and Meta-Analysis
N Izadi et al, MEDRXIV, May 6, 2020

The reproduction number of COVID-19 and its correlation with public health interventions
K Linka et al, MEDRXIV, May 6, 2020

Predictive mathematical models for the number of individuals infected with COVID-19
AS Fokas et al, MEDRXIV, May 6, 2020

Racial Health Disparities and Covid-19 — Caution and Context
M Chowkwamyun et al, NEJM, May 6, 2020

Updates in BRCA testing for People of Ashkenazi Jewish Ancestry
L Steinmark, Jackson Labs, May 3, 2020

For the past few decades, genetic providers and researchers have recognized the importance of the three BRCA founder mutations and were able to test specifically for them in individuals at risk, defined as having Ashkenazi ancestry and a personal or family history of breast and/or ovarian cancer.

Clinical experience with carrier screening in a general population: support for a comprehensive pan-ethnic approach
M Westemeyer et al, Genetics in Medicine, May 6, 2020

Compared with standard screening, NGS-based CS provides additional information that may impact reproductive choices. Pan-ethnic CS leads to substantially increased identification of at-risk couples.

Clinical utility of 24-h rapid trio-exome sequencing for critically ill infants
H Wang et al, NPJ Genomic Medicine, May 6, 2020

Of 33 enrolled infants, 23 received positive results with rapid TES. Rapid TES enabled faster time to diagnosis, which resulted in an overall decrease in length of hospital stay. The 24-h TES can serve as a rapid response tool for patients with suspected monogenic disorders.

Internet Search Patterns Reveal Clinical Course of Disease Progression for COVID-19 and Predict Pandemic Spread in 32 Countries
T Lu et al, MEDRXIV, May 6, 2020

There is a critical need for complementary surveillance approaches that can function at population-scale to inform public health decisions in real-time. Internet search patterns provide important advantages. We conducted a detailed global study of Internet search patterns related to COVID-19 symptoms in multiple languages across 32 countries on six continents


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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