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Hot Topics of the Day|PHGKB
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04/23/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

The Challenge of Tracking COVID-19’s Stealthy Spread
NIH Director's Blog, April 23, 2020

NIAID strategic plan details COVID-19 research priorities
NIH, April 23, 2020 Brand

This include four key priorities. The first involves improving fundamental knowledge of virus including studies to characterize the virus and better understand how it causes infection and disease. This includes natural history, transmission studies to determine why some individuals experience mild symptoms while others become critically ill.

Community and Socioeconomic Factors Associated with COVID-19 in the United States: Zip code level cross sectional analysis
A Guha et al, MEDRXIV, April 22, 2020

Researchers Study Why Men Seem To Be More Affected By COVID-19
NPR, April 23, 2020

Detection of SARS-CoV-2 RNA by direct RT-qPCR on nasopharyngeal specimens without extraction of viral RNA
MR Hasan et al, MEDRXIV, April 23, 2020

The Novel Coronavirus Disease (COVID-19): A PRISMA Systematic Review and Meta-analysis of Clinical and Paraclinical characteristics
H Hazani et al, MEDRXIV, April 23, 2020

Identification of super-transmitters of SARS-CoV-2
X Yang et al, MEDRXIV, April 23, 2020

Four genetic clusters defined as Super-transmitters (STs) were found to become dominant and were responsible for the major outbreaks in various countries.

Population genomics insights into the recent evolution of SARS-CoV-2
M Vasilarou et al, BIORXIV, April 23, 2020

In this study, we used population genetics analysis to infer the mutation rate and plausible recombination events that may have contributed to the evolution of the SARS-CoV-2 virus. Furthermore, we localized targets of recent and strong positive selection.

Is ethnicity linked to incidence or outcomes of covid-19?
BMJ Editorial, April 20, 2020

Ethnic minority groups have been disproportionately affected by covid-19 in the US, highlighting potential racial, economic, and other inequalities.

The impact of genomics on precision public health
Call for Papers, Genome Medicine, April 22, 2020

Human and pathogen genomics are at the leading edge of the application of new technologies to public health practice. Research efforts in this area are contributing to a new era of 'precision public health', an emerging multidisciplinary field that uses genomics, other big data and artificial intelligence to improve population health.

Clinical Genomics Data for Precision Medicine
S Garcia et al, Health IT Buzz, April 22, 2020

Four organizations showed how genomic data can be exchanged for newborn screening, cancer treatment, pharmacogenomics, and bone marrow matching. The four organizations explored practical data transfer between genomic laboratories, healthcare providers, researchers, and patients.

Sync for Genes: Making Clinical Genomics Available for Precision Medicine at the Point-of-Care
SG Garcia et al, Appl Clin Informatics, April 2020

The goals of Sync for Genes were to (1) demonstrate exchange of genomic data using health data standards, (2) provide feedback for refinement of health data standards, and (3) synthesize project experiences to support the integration of genomic data at the point-of-care and for research.

A catalogue of cancer-driving mutations in healthy tissue
Nature News, April 22, 2020

A study of cancer-associated mutations in normal endometrial glands of the uterus has now been performed using whole-genome sequencing. The analysis sheds light on the early changes that lead to invasive disease.

Role of RNA modifications in cancer
I Barbieri et al, Nature Reviews Cancer, April 2020

A framework for an evidence-based gene list relevant to autism spectrum disorder.
Schaaf Christian P et al. Nature reviews. Genetics 2020 Apr

In clinical practice, providers need to decide which genes to test in individuals with ASD phenotypes, which requires an understanding of the level of evidence for individual genes that supports an association with ASD. Consensus is currently lacking about which NDD genes have sufficient evidence to support a relationship to ASD.

Cardiovascular Complications of COVID-19
M McGowan, The FH Foundation, April 22, 2020

Infection with COVID-19 has been associated with multiple cardiac complications including: heart attack, myocarditis (inflammation of the heart muscle), arrhythmias (heart rhythm disturbances) and blood clots. Most people will recover from a COVID-19 infection. Our aim at the FH Foundation is to empower individuals to make the most informed medical choices.

Whole‐Genome Approach Discovers Novel Genetic and Nongenetic Variance Components Modulated by Lifestyle for Cardiovascular Health
X Zhou et al, JAHA, April 2020

We used a novel whole-genome approach to estimate the genetic and nongenetic effects on—and hence their predispositions to—cardiovascular risk and determined whether they vary with respect to lifestyle factors such as physical activity, smoking, alcohol consumption, and dietary intake.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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