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Hot Topics of the Day|PHGKB
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04/22/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

The Public Health Impact of COVID-19: Why Host Genomics?
MJ Khoury el al, CDC Blog, April 21, 2020 Brand

Ideally, scientific studies of COVID-19 risk factors for transmission and severity should include both viral and human genomes and the interaction of these two genomes, along with other traditional environmental, social and economic factors, and emerging types of big data. This is part of a precision public health response.

Coronavirus Disease 2019 (COVID-19) Treatment Guidelines
NIH, April 21, 2020 Brand

A New Resource for Genomics and Precision Health Information and Publications on the Investigation and Control of COVID-19 and other Coronaviruses
W Yu et al, BIORXIV, April 21, 2020

We developed a new online database that contains the most updated published scientific literature, online news and reports, CDC and National Institutes of Health resources. The tool captures emerging discoveries and applications of genomics, molecular, and other precision health tools in the investigation and control of coronavirus diseases.

Expert U.S. panel develops NIH treatment guidelines for COVID-19- “Living document” expected to be updated often as new clinical data accrue.
NIH, April 21, 2020 Brand

Host, Viral, and Environmental Transcriptome Profiles of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
D Butler et al, BIORXIV, April 21, 2020

Ethnicity and COVID-19: an urgent public health research priority
M Pareek et al, The Lancet, April 21, 2020

Solving the mysteries of coronavirus with genetic fingerprints
M Baker et al, NY Times, April 22, 2020

Using advanced genomic technology, scientists made two disconcerting discoveries. The first was that the virus brought in by someone who arrived from Wuhan carrying a nearly identical strain — had managed to settle into the population undetected. Then they began to realize how far it had spread.

Modeling projections for COVID-19 pandemic by combining epidemiological, statistical, and neural network approaches
S Uhlig et al, MEDRXIV, April 22, 2020

Based on deterministic compartment models we propose an empirical top-down modeling approach to provide epidemic forecasts and risk calculations for (local) outbreaks. We use neural networks to develop leading indicators based on available data for different regions.

How many are at increased risk of severe COVID-19 disease? Rapid global, regional and national estimates for 2020
A Clark et al, MEDRXIV, April 22, 2020

We analysed data from two large multimorbidity studies to determine appropriate adjustment factors for clustering and multimorbidity. Results We estimate that 1.7 (1.0 - 2.4) billion individuals (22% [15-28%] of the global population) are at increased risk of severe COVID-19 disease

Interleukin-6 blockade for severe COVID-19
M Roumier et al, MEDRXIV, APril 22, 2020

Estimates of COVID-19 case-fatality risk from individual-level data
S Bignami et al, MEDRXIV, April 22, 2020

Increased PCR screening capacity using a multi-replicate pooling scheme
A Viehweger et al, MEDRXIV, April 22, 2020

COVID-19 research has overall low methodological quality thus far: case in point for chloroquine/hydroxychloroquine
PE Alexander et al, J Clin Epi, April 21, 2020

FDA OKs First COVID-19 Test Kit With Home Collection Option
L Francki, Medscape, April 21, 2020

Primary Immunodeficiency (PI)
CDC, April 2020 Brand

There are more than 400 types of genetic PI that vary in severity, which affects how early they are detected. In some cases, a person with a mild form may not find out that they have PI until adulthood. In other cases, the disorder causes problems in infancy and is found soon after birth.

Multiplexed Proteomic Analysis for Diagnosis and Screening of Five Primary Immunodeficiency Disorders From Dried Blood Spots.
Collins Christopher J et al. Frontiers in immunology 2020 11464

Investigating the Link between Lynch Syndrome and Breast Cancer.
Sheehan Megan et al. European journal of breast health 2020 Apr 16(2) 106-109

Microbiome genomics for cancer prediction
L Adlung et al, Nature Cancer, April 2020

Although cancer genomics is a powerful tool to understand cancer and develop diagnostic tools, the contribution of the microbiome in cancer diagnosis and clinical assessment is much less studied. Several authors provide their respective views on how studying cancer metagenomes could facilitate identification, diagnosis and staging of different tumor types.

Self-reported COVID-19 symptoms on Twitter: An analysis and a research resource
A Sarkeer et al, MEDRXIV, April 22, 2020

We identified 203 positive-tested users who reported 932 symptoms using 598 unique expressions. The most frequently-reported symptoms were fever/pyrexia (65%), cough (56%), body aches/pain (40%), headache (35%), fatigue (35%), and dyspnea (34%) amongst users who reported at least 1 symptom.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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