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Hot Topics of the Day|PHGKB
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03/01/2024

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Educational Mobility, Pace of Aging, and Lifespan Among Participants in the Framingham Heart Study
GH Graaf et al, JAMA Network Open, March 1, 2024

From the abstract: " Is upward educational mobility associated with a slower pace of biological aging and increased longevity? In this cohort study of 3101 participants representing 2 generations of the Framingham Heart Study, upward educational mobility was associated with a slower pace of aging (as measured with whole-blood DNA-methylation data) and lower risk of death. Slower pace of aging accounted for approximately half of the association between educational mobility and mortality. These results suggest that interventions to promote educational attainment may slow the pace of biological aging and promote longevity. "

Integrating artificial intelligence into healthcare systems: more than just the algorithm
JC Kwong et al, NPJ Digital Medicine, March 1, 2024

From the abstract: "Despite the rapid growth of artificial intelligence (AI) applications in healthcare, few models have progressed beyond retrospective development or validation, creating what is commonly called the “AI chasm”. Among the subset of models that have moved into randomized controlled trials, even fewer have demonstrated clinically meaningful benefits. This reality is a sobering reminder that translating AI algorithms from in silico environments to real-world clinical settings remains a formidable challenge. "

Exome and genome sequencing in a heterogeneous population of patients with rare disease: Identifying predictors of a diagnosis
J Pucel et al, Genetics in Medicine, March 1, 2024

From the abstract: "In this case control study, we reviewed data from 400 diagnosed and 400 undiagnosed randomly selected participants in the Undiagnosed Diseases Network (UDN), all of whom had undergone ES and/or GS. We analyzed factors associated with receiving a diagnosis by ES and/or GS. Factors associated with a decreased odds of being diagnosed included adult symptom onset, singleton sequencing, and having undergone ES and/or GS prior to acceptance to the UDN (48%, 51%, and 32% lower odds, respectively). Factors that increased the odds of being diagnosed by ES and/or GS included having primarily neurological symptoms and having undergone prior chromosomal microarray testing. "

Researchers optimize genetic tests for diverse populations to tackle health disparities
NIH, February 2024 Brand

From the website: " To prevent an emerging genomic technology from contributing to health disparities, a scientific team funded by the National Institutes of Health has devised new ways to improve a genetic testing method called a polygenic risk score. Since polygenic risk scores have not been effective for all populations, the researchers recalibrated these genetic tests using ancestrally diverse genomic data. As reported in Nature Medicine, the optimized tests provide a more accurate assessment of disease risk across diverse populations."


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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